C–H Functionalization has the potential to become a paradigmshifting strategy for organic synthesis. Over the last decade, the field has experienced explosive growth and a large variety of new C–H functionalization methodologies have been developed. In particular, regioselective functionalization of sp² C–H bonds has become a broadly flexible approach for the synthesis of complex aromatic carbocycles and heterocycles. The selective functionalization of sp³C–H bonds is a more challenging proposition, but in recent years significant advances have been made to suggest that even these types of transformations can become broadly applicable. This Thematic Series highlights some of the novel approaches that are applied to the field of C–H functionalization and it covers topics that range from novel catalyst design, new synthetic methods, and cascade sequences that incorporate C–H functionalization.

See also the Thematic Series:
C–H Functionalization/activation in organic synthesis