Strategies in asymmetric catalysis

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Editor: Prof. Tehshik P. Yoon
University of Wisconsin-Madison
 
The stereochemistry of an organic compound can have a profound influence on many of its most important properties. For example, the enantiomeric forms of a drug molecule can have completely different biological effects, and polymers that differ only in the stereochemistry of their backbones can have quite dissimilar macroscopic physical characteristics. Control over the stereochemical outcome of organic reactions has thus long been recognized as a central concern across multiple sectors of modern synthetic chemistry. Thus, the design of asymmetric catalytic systems remains an active and vital research area. Current progress in the field of asymmetric catalysis continues to be driven both by conceptual innovations as well as demonstrations of the applicability of enantioselective catalytic reactions to increasingly complex synthetic problems.

See also the Thematic Series:
Bifunctional catalysis
Sustainable catalysis

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Strategies in asymmetric catalysis

  • Tehshik P. Yoon

Beilstein J. Org. Chem. 2017, 13, 63–64, doi:10.3762/bjoc.13.8

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Published 10 Jan 2017

NeoPHOX – a structurally tunable ligand system for asymmetric catalysis

  • Jaroslav Padevět,
  • Marcus G. Schrems,
  • Robin Scheil and
  • Andreas Pfaltz

Beilstein J. Org. Chem. 2016, 12, 1185–1195, doi:10.3762/bjoc.12.114

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Published 13 Jun 2016

Conjugate addition–enantioselective protonation reactions

  • James P. Phelan and
  • Jonathan A. Ellman

Beilstein J. Org. Chem. 2016, 12, 1203–1228, doi:10.3762/bjoc.12.116

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Review
Published 15 Jun 2016

Synergistic chiral iminium and palladium catalysis: Highly regio- and enantioselective [3 + 2] annulation reaction of 2-vinylcyclopropanes with enals

  • Haipan Zhu,
  • Peile Du,
  • Jianjun Li,
  • Ziyang Liao,
  • Guohua Liu,
  • Hao Li and
  • Wei Wang

Beilstein J. Org. Chem. 2016, 12, 1340–1347, doi:10.3762/bjoc.12.127

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Published 29 Jun 2016

Selective bromochlorination of a homoallylic alcohol for the total synthesis of (−)-anverene

  • Frederick J. Seidl and
  • Noah Z. Burns

Beilstein J. Org. Chem. 2016, 12, 1361–1365, doi:10.3762/bjoc.12.129

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Published 01 Jul 2016

Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions

  • Yasuhiro Yamashita,
  • Susumu Yoshimoto,
  • Mark J. Dutton and
  • Shū Kobayashi

Beilstein J. Org. Chem. 2016, 12, 1447–1452, doi:10.3762/bjoc.12.140

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Published 13 Jul 2016

Enantioconvergent catalysis

  • Justin T. Mohr,
  • Jared T. Moore and
  • Brian M. Stoltz

Beilstein J. Org. Chem. 2016, 12, 2038–2045, doi:10.3762/bjoc.12.192

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Published 16 Sep 2016

Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles

  • Masahiro Torii,
  • Kohsuke Kato,
  • Daisuke Uraguchi and
  • Takashi Ooi

Beilstein J. Org. Chem. 2016, 12, 2099–2103, doi:10.3762/bjoc.12.199

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Published 28 Sep 2016

Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element

  • Reji Thomas and
  • Nobuyuki Tamaoki

Beilstein J. Org. Chem. 2016, 12, 2211–2215, doi:10.3762/bjoc.12.212

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Published 19 Oct 2016

Highly chemo-, enantio-, and diastereoselective [4 + 2] cycloaddition of 5H-thiazol-4-ones with N-itaconimides

  • Shuai Qiu,
  • Choon-Hong Tan and
  • Zhiyong Jiang

Beilstein J. Org. Chem. 2016, 12, 2293–2297, doi:10.3762/bjoc.12.222

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Published 01 Nov 2016

Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

  • Pierre Querard,
  • Inna Perepichka,
  • Eli Zysman-Colman and
  • Chao-Jun Li

Beilstein J. Org. Chem. 2016, 12, 2636–2643, doi:10.3762/bjoc.12.260

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Published 06 Dec 2016

Chromium(II)-catalyzed enantioselective arylation of ketones

  • Gang Wang,
  • Shutao Sun,
  • Ying Mao,
  • Zhiyu Xie and
  • Lei Liu

Beilstein J. Org. Chem. 2016, 12, 2771–2775, doi:10.3762/bjoc.12.275

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Published 19 Dec 2016

New approaches to organocatalysis based on C–H and C–X bonding for electrophilic substrate activation

  • Pavel Nagorny and
  • Zhankui Sun

Beilstein J. Org. Chem. 2016, 12, 2834–2848, doi:10.3762/bjoc.12.283

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Published 23 Dec 2016

Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

  • Alejandro Castán,
  • Ramón Badorrey,
  • José A. Gálvez and
  • María D. Díaz-de-Villegas

Beilstein J. Org. Chem. 2017, 13, 612–619, doi:10.3762/bjoc.13.59

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Published 27 Mar 2017
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