Beilstein J. Org. Chem.2023,19, 646–657, doi:10.3762/bjoc.19.46
-containing heterocycles intensively studied in medicinal chemistry and pharmacology. In the present paper, a new synthetic approach to pyrrolobenzothiazoles is developed based on 1,4-thiazine ring contraction in 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones under the action of nucleophiles. The
targeted cancer therapy development.
Keywords: 1,4-benzothiazine; 1,3-benzothiazole; 1H-pyrrole-2,3-diones; nitrogen heterocycle; sulfur heterocycle; Introduction
Pyrrolo[2,1-b][1,3]benzothiazole (PBTA) is an angularly fused sulfur and nitrogen-containing heterocyclic scaffold. Its derivatives are
, recently, we have reported a new class of FPDs, aroylpyrrolobenzothiazinetriones (APBTTs) 1 (Figure 2) [37][38], whose structural features allowed us to assume a possibility of the development of a new approach to PBTAs via a nucleophile-induced ring contraction in the 1,4-benzothiazine moiety of compounds
Beilstein J. Org. Chem.2020,16, 2322–2331, doi:10.3762/bjoc.16.193
; 1,4-benzothiazine; cyclocondensation; diversity-oriented synthesis; furan-2,3-dione; Introduction
Enaminones fused to the 1,4-benzoxazine-2-one I or quinoxaline-2(1H)-one II moiety (Figure 1) represent an intensively investigated class of enamines. Undying interest in these compounds is due to the
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Graphical Abstract
Figure 1:
Enaminones fused to heterocyclic moieties.