Beilstein J. Org. Chem.2024,20, 1029–1036, doi:10.3762/bjoc.20.91
of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 166 10 Prague, Czech Republic 10.3762/bjoc.20.91 Abstract The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process
: antivirotics; nonnucleotide inhibitor; RNA-dependent RNA polymerase; SARS-CoV-2; Introduction
Epidemics caused by various viral infections, such as AIDS, Zika fever, Dengue fever, or Ebola, are a constant threat to communities of all sizes [1]. The COVID-19 pandemic, caused by the newly emerged severe acute
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Graphical Abstract
Figure 1:
Structure of HeE1-2Tyr (1) and of the derivatives synthesized in this work.