Beilstein J. Org. Chem.2024,20, 830–840, doi:10.3762/bjoc.20.75
protect bacteria from exposure to NNG.
Keywords: enzymology; natural products; nitramine; N–N bond; Introduction
Degradation of nitramines (R–N(R′)NO2; R′ = H or alkyl) has been well studied in the context of the environmental degradation of explosive cyclic nitramines [1][2]. The cyclic nitramines
carcinogenicity [3][4][5][6][7][8]. Biotic and abiotic degradation of cyclic nitramines often produce linear nitramine byproducts. For example, degradation of RDX and HMX by microbes or alkaline hydrolysis forms the linear nitramine 4-nitro-2,4-diazabutanal (NDAB) [9][10][11][12]. Linear nitramines are also
], there is far less known regarding the environmental biodegradation pathways of linear nitramine contaminants. Biodegradations of NDAB by the fungus Phanerochaete chrysosporium and the bacterium Methylobacterium sp. strain JS178 have been reported [17][18]. Initiation of the P. chrysosporium degradation
Beilstein J. Org. Chem.2015,11, 1833–1864, doi:10.3762/bjoc.11.199
spiropiperidine alkaloid nitramine was proved to be efficient by this methodology (Scheme 13).
In 2004, Ni and Ma [18] have described the synthesis of bicyclic compounds 75 and 76 by adopting a metathesis protocol with catalysts 1 and 2 in good yields, but the product ratio is catalyst-dependent. In this context
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Graphical Abstract
Figure 1:
Ruthenium alkylidene catalysts used in RRM processes.