Beilstein J. Org. Chem.2021,17, 2194–2202, doi:10.3762/bjoc.17.141
nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp. AKA43 collected from floating particles in the deep-sea water of Sagami Bay, Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, and the
cytotoxicity against P388 murine leukemia cells with IC50 values of 33 and 89 μM, respectively.
Keywords: Actinomadura; nomimicin; polyketide; spirotetronate; Introduction
Actinomycetes are a valuable source of bioactive compounds, accounting for approximately two thirds of all known antibiotics, and more
, nomimicin A (4) [15]. From the extract of the fermentation broth cultured in A11M medium, an additional new tetronate polyketide, nomimicin D (3), was isolated (Figure 1).
Nomimicin B (1) was obtained as a colorless amorphous solid. The molecular formula was determined to be C30H40O8, based on the
PDF
Graphical Abstract
Figure 1:
Structures of nomimicins A–D (4 and 1–3).