Computational prediction of C–H hydricities and their use in predicting the regioselectivity of electron-rich C–H functionalisation reactions
- Rasmus M. Borup,
- Nicolai Ree and
- Jan H. Jensen
Beilstein J. Org. Chem. 2026, 22, 603–610, doi:10.3762/bjoc.22.46
![[Graphic 6]](/bjoc/content/inline/1860-5397-22-46-i8.svg?max-width=637&scale=1.18182)
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs
- Sophie Day-Riley,
- Sona Krajcovicova,
- Aryaman Raj Sokhal,
- Jan L. Venne,
- Paul Brear,
- Marko Hyvönen,
- Benjamin C. Whitehurst,
- Jason S. Carroll and
- David R. Spring
Beilstein J. Org. Chem. 2026, 22, 611–619, doi:10.3762/bjoc.22.47
Hydrogen production from formic acid catalyzed by NHC–Cu complexes
- Orlando Santoro and
- Catherine S. J. Cazin
Beilstein J. Org. Chem. 2026, 22, 620–627, doi:10.3762/bjoc.22.48
Advantages of PROTACs in achieving selective degradation of homologous protein families
- Luxi Yang,
- Xinfei Mao,
- Jingyi Zhang,
- Jing Shu,
- Wenhai Huang,
- Xiaowu Dong,
- Yinqiao Chen and
- Mingfei Wu
Beilstein J. Org. Chem. 2026, 22, 628–661, doi:10.3762/bjoc.22.49
Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions
- Egor N. Boronin,
- Svetlana E. Kaurkina,
- Milena M. Svetlakova,
- Anton S. Bolshakov,
- Maxim V. Arsenyev,
- Vasilii F. Otvagin,
- Alexey Yu. Fedorov,
- Timothy Noël and
- Alexander V. Nyuchev
Beilstein J. Org. Chem. 2026, 22, 662–671, doi:10.3762/bjoc.22.50
Using generative AI to transform peptide hits into small molecule leads
- Joshua Mills and
- Yu Heng Lau
Beilstein J. Org. Chem. 2026, 22, 672–679, doi:10.3762/bjoc.22.51
Harnessing light energy with molecules
- Grace G. D. Han,
- Mogens Brøndsted Nielsen and
- Hermann A. Wegner
Beilstein J. Org. Chem. 2026, 22, 680–682, doi:10.3762/bjoc.22.52
Synthesis of depressin, cryptomeridiol and 4-epi-cryptomeridiol enabled by a terpenoid chiral pool-producing platform
- Yao Kong,
- Tao Wang,
- Chen Wang,
- Pengcheng Zhang,
- Yuanning Liu,
- Kaibiao Wang,
- Fen Liu,
- Hongli Jia and
- Zhengren Xu
Beilstein J. Org. Chem. 2026, 22, 683–690, doi:10.3762/bjoc.22.53
Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma
- Chen Zhang,
- Kah Yean Lum,
- Jonathan M. White,
- Paul I. Forster,
- Nicholas Booth,
- Sunita A. Ramesh and
- Rohan A. Davis
Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54
Synthesis of heterocycles based on azomethine ylides from α-amino acids (or amines) and carbonyl compounds
- Ekaterina V. Berezhnaya,
- Alexander I. Ponyaev,
- Vitali M. Boitsov and
- Alexander V. Stepakov
Beilstein J. Org. Chem. 2026, 22, 705–741, doi:10.3762/bjoc.22.55
Rongalite addition to dienones: diastereoselectivity in cyclic sulfone synthesis; stereochemical rationalization and prospects as a general conjugate nucleophile
- Melina Goga,
- Hao Zong,
- James Franco,
- Jazmine Prana,
- Rudolph Michel,
- Antonia Muro,
- Elana Rubin,
- Janet Brenya,
- Henk Eshuis and
- Magnus W. P. Bebbington
Beilstein J. Org. Chem. 2026, 22, 742–752, doi:10.3762/bjoc.22.56
Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function
- María Núñez,
- Camila Escobar,
- Mario Párraga,
- Mauricio Soto,
- Luis Espinoza-Catalán,
- Katy Díaz and
- Andrés F. Olea
Beilstein J. Org. Chem. 2026, 22, 753–762, doi:10.3762/bjoc.22.57
Preparation of 3-(alkylamino)imidazo[1,2-a]pyridine-2-carbaldehydes via Kornblum oxidation and unexpected ring-opening reactions of the corresponding alcohols under oxidative conditions
- Sandile J. Mkhize,
- Memory Zimuwandeyi,
- Manuel A. Fernandes,
- Amanda L. Rousseau and
- Moira L. Bode
Beilstein J. Org. Chem. 2026, 22, 763–770, doi:10.3762/bjoc.22.58
Design, synthesis, and biological evaluation of FXR/ASK1 dual-target modulators
- Xi Zhang,
- Jingyan Wang,
- Ziqiang Zhao,
- Caiyi Wang,
- Zenghui Ye,
- Wei-Yuan Ma,
- Jian-Xing Xu and
- Fengzhi Zhang
Beilstein J. Org. Chem. 2026, 22, 771–781, doi:10.3762/bjoc.22.59
Halogenated azobenzene acrylates: from efficient solution photoswitching to stable solid-state photochromic materials
- Martina Vachtlová,
- Michaela Fecková,
- Vítězslav Zima,
- Jan Podlesný,
- Milan Klikar,
- Oldřich Pytela,
- Patrik Pařík,
- Jakub Opršal,
- Eliška Juhaňáková,
- Veronika Chrtová and
- Filip Bureš
Beilstein J. Org. Chem. 2026, 22, 782–794, doi:10.3762/bjoc.22.60
Synthetic study of vic-bromination of diarylacetylenes, easy purification and separation
- Akane Togo,
- Hiyono Suzuki,
- Yuto Akai,
- Makoto Matsumoto,
- Yoshinori Suzuma,
- Hidehiko Kodama and
- Kouichi Matsumoto
Beilstein J. Org. Chem. 2026, 22, 795–802, doi:10.3762/bjoc.22.61
Knoevenagel condensation of 4,5- and 1,8-diazafluorenes
- Darya S. Cheshkina,
- Christina S. Becker,
- Alina A. Sonina and
- Maxim S. Kazantsev
Beilstein J. Org. Chem. 2026, 22, 803–812, doi:10.3762/bjoc.22.62
Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine
- Irene Moreno-Gutiérrez,
- Josefa L. López-Martínez,
- Sonia Berenguel-Gómez,
- Irene Torres-García,
- Duane Choquesillo-Lazarte,
- Manuel Muñoz-Dorado,
- Miriam Álvarez-Corral and
- Ignacio Rodríguez-García
Beilstein J. Org. Chem. 2026, 22, 813–820, doi:10.3762/bjoc.22.63
Total synthesis of the capsular polysaccharide repeating unit towards the development of a glycoconjugate vaccine against Klebsiella pneumoniae ST512
- Shuo Zhang,
- Ondřej Daněk and
- Peter H. Seeberger
Beilstein J. Org. Chem. 2026, 22, 821–827, doi:10.3762/bjoc.22.64
Unsymmetrical sulfoxides with sterically hindered catechol fragment: synthesis, structure, electrochemical properties, and antiradical activity
- Daria A. Burmistrova,
- Vasiliy A. Fokin,
- Oleg P. Demidov,
- Mikhail A. Kiskin,
- Maxim V. Arsenyev,
- Andrey I. Poddel’sky,
- Nadezhda T. Berberova and
- Ivan V. Smolyaninov
Beilstein J. Org. Chem. 2026, 22, 828–837, doi:10.3762/bjoc.22.65
The trans-influence in gold chemistry from a catalytic perspective
- Manfred Bochmann
Beilstein J. Org. Chem. 2026, 22, 838–856, doi:10.3762/bjoc.22.66
Site-specific labelling of native peptides and proteins: chemical and enzymatic strategies
- Antonio Angelastro,
- Jonathan Bargh,
- Subhajit Guria,
- Victor Laserna and
- Louis Luk
Beilstein J. Org. Chem. 2026, 22, 857–881, doi:10.3762/bjoc.22.67
Diastereodivergent electrophilic trapping of α-boryl lithium derivatives
- Tereza Pavlíčková,
- Noam Orbach and
- Ilan Marek
Beilstein J. Org. Chem. 2026, 22, 882–887, doi:10.3762/bjoc.22.68
Chiral cyclopropenimine-catalyzed enantioselective Michael reactions of phenol and benzofuran-derived α,β-unsaturated pyrazolamides with benzophenone-imine of glycine esters
- Ya Bai,
- Xue-Ying Wang,
- Si-Kai Zhu,
- Yan-Ting Shen,
- Sheng-Yong Zhang and
- Ping-An Wang
Beilstein J. Org. Chem. 2026, 22, 888–896, doi:10.3762/bjoc.22.69
Cascade transformation of 2-(diazoacetyl)-2H-azirines to 2-aroyl-3-hydroxy-1H-pyrroles via condensation with aromatic aldehydes
- Timur O. Zanakhov,
- Ekaterina E. Galenko,
- Mikhail S. Novikov and
- Alexander F. Khlebnikov
Beilstein J. Org. Chem. 2026, 22, 897–904, doi:10.3762/bjoc.22.70
