Abstract

Multimodal imaging technology were extensively studied over past few years, because they offered complementary diagnosis information, which can increase the accuracy of diagnosis. The synthesis of contrast agents via simplified methods are desired for the development of multimodal imaging. Herein, uniformly distributed Fe₃O₄/Gd₂O₃ nanocubes for T₁-T₂ dual-mode contrast agents were rationally designed and successfully fabricated by our group. In this system, the Fe₃O₄/Gd₂O₃ nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA) for better hydrophilia and biocompatibility. The results show that Ferrum (Fe) and Gadolinium (Gd) elements are homo-dispersity in the Fe₃O₄/Gd₂O₃-DHCA (FGDA) nanocubes. Relaxivity study at 3.0 T scanner demonstrates that the r₁ value and r₂ value of FGDA nanocubes reach up to 67.57 ± 6.2 mM^-1s^-1 and 24.2 ± 1.46 mM^-1s^-1. The images of T₁-weighted and T₂-weighted imaging in vivo demonstrate that FGDA nanocubes possess the ability of magnetic resonance (MR) imaging enhancement as dual-mode contrast agent. The above illustrated experimental results indicate that FGDA nanocubes can be applied in clinical diagnosis in future.

Keywords: Fe₃O₄/Gd₂O₃-DHCA nanocubes, dual-mode imaging, Magnetic Resonance Imaging.

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Qin, M.; Peng, Y.; Xu, M.; Yan, H.; Cheng, Y.; Zhang, X.; Huang, D.; Chen, W.; Meng, Y. Beilstein Arch. 2020, 202050. doi:10.3762/bxiv.2020.50.v1

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