Size- and concentration-dependence of antiviral and virucidal activity of Au nanoparticles against adenoviruses and influenza viruses H1N1

Maryna Chaika; Krystyna Naumenko; Yuliia Pankivska; Olga Povnitsa; Iuliia Mukha; Nadiya Vityuk; Anatoliy Dorovskih; Valeri Lozovski; Volodymyr Lysenko; Mykhailo Lokshyn; Natalia M. Rusinchuk; Svitlana Zagorodnya

doi:10.3762/bxiv.2021.92.v1

Size- and concentration-dependence of antiviral and virucidal activity of Au nanoparticles against adenoviruses and influenza viruses H1N1

Maryna Chaika ,
Krystyna Naumenko ,
Yuliia Pankivska ,
Olga Povnitsa ,
Iuliia Mukha ,
Nadiya Vityuk ,
Anatoliy Dorovskih ,
Valeri Lozovski ,
Volodymyr Lysenko ,
Mykhailo Lokshyn ,
Natalia M. Rusinchuk and
Svitlana Zagorodnya

Submitting author affiliation:

Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

Beilstein Arch. 2021, 202192. https://doi.org/10.3762/bxiv.2021.92.v1

Published 27 Dec 2021

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.

SUBJECT AREAS

Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

Over the past 10 years, many scientific groups have experimentally shown that non-functionalized nanoparticles show a pronounced antiviral and antimicrobial action against different pathogens. In order to understand the mechanism of nanoparticles action it is important to know its peculiarities, i.e. dependences on different nanoparticles and pathogen properties.

In this work we studied how Au nanoparticles act on the viruses outside and inside the cell, and compare this action for two sizes of nanoparticles and two types of the viruses. The study has been conducted for adenovirus and H1N1 influenza virus, and nanoparticles of 5 nm and 20 nm diameter.

Virucidal and antiviral actions were observed experimentally for both types of nanoparticles against both viruses. It has been shown that intensity of virucidal action depends on the nanoparticles concentration non-monotonically for adenovirus. It has also been shown with electron microscopy that the viruses are destructed after 5 nm nanoparticles adsorption on their surface; and that the viruses change their shape after 20 nm nanoparticles adsorption on their surface. The model of physical adsorption of nanoparticles on the virus surface due to near-field interaction proposed in previous works may explain observed results on virucidal action of nanoparticles.

Keywords: Au nanoparticles; antiviral action; virucidal action; adenovirus; influenza virus H1N1.

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Chaika, M.; Naumenko, K.; Pankivska, Y.; Povnitsa, O.; Mukha, I.; Vityuk, N.; Dorovskih, A.; Lozovski, V.; Lysenko, V.; Lokshyn, M.; Rusinchuk, N. M.; Zagorodnya, S. Beilstein Arch. 2021, 202192. doi:10.3762/bxiv.2021.92.v1

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© 2021 Chaika et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
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benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)