Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

Brunno Renato Farias Verçoza; Robson Roney Bernardo; Luiz Agusto Sousa de Oliveira; Juliany Cola Fernandes Rodrigues

doi:10.3762/bxiv.2023.17.v1

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

Brunno Renato Farias Verçoza ,
Robson Roney Bernardo ,
Luiz Agusto Sousa de Oliveira and
Juliany Cola Fernandes Rodrigues

Submitting author affiliation:

Universidade Federal do Rio de Janeiro, Duque de Caxias, Brazil

Beilstein Arch. 2023, 202317. https://doi.org/10.3762/bxiv.2023.17.v1

Published 24 Apr 2023

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Read the peer-reviewed version of this preprint: https://doi.org/10.3762/bjnano.14.73

SUBJECT AREAS

Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

Objective: The main goal of this work was to evaluate the therapeutic potential of green SPIONs produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis. Materials and methods: Optical and electron microscopy techniques were used to evaluate the effects on cell proliferation, infectivity percentage, and ultrastructure. Results: SPIONs were internalized by both parasite stages, randomly distributed by the cytosol located mainly in membrane-bound compartments. The selectivity index for intracellular amastigotes was higher than 240 times compared to current drugs used to treat the disease. Conclusion: The synthesized SPIONs showed an important and promising anti-Leishmania activity and can be considered a strong candidate for a new therapeutic approach for treating leishmaniases.

Keywords: Leishmaniasis; SPIONs; Leishmania amazonensis; nanomedicine; coconut water.

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Verçoza, B. R. F.; Bernardo, R. R.; de Oliveira, L. A. S.; Rodrigues, J. C. F. Beilstein Arch. 2023, 202317. doi:10.3762/bxiv.2023.17.v1

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