Beilstein Arch. 2023, 202358. https://doi.org/10.3762/bxiv.2023.58.v1
Published 07 Dec 2023
Penicillium strains are renowned for producing diverse secondary metabolites with unique structures and promising bioactivities. Our chemical investigations, accompanied by fermentation media optimization, of a newly isolated fungus, Penicillium shentong XL-F41, led to the isolation of twelve compounds. Among these are two novel indole terpene alkaloids, Shentonin A and B (1 and 2), and a new fatty acid (3). 1 is distinguished by an unusual methyl modification at the oxygen atom of the typical succinimide ring, a feature not seen in the structurally similar brocaeloid D. Additionally, 1 exhibits a cis configuration between H-3 and H-4, as opposed to the trans configuration in brocaeloid D, suggesting a divergent enzymatic ring-expansion process in their respective fungi. Both 1 and 2 also feature a reduction of a ketone to a hydroxyl group within the succinimide ring. All isolated compounds were subjected to antimicrobial evaluations, and compound 12 was found to have moderate inhibitory activity against Candia albicans. Moreover, genome sequencing of Penicillium shentong XL-F41 uncovered abundant silent biosynthetic gene clusters, indicating the need for future efforts to activate these clusters and unlock the full chemical potential of the fungus.
Keywords: Penicillium; natural products; indole terpene alkaloid; structure elucidation; genome analysis;
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Zou, R.; Li, X.; Chen, X.; Guo, Y.-W.; Xu, B. Beilstein Arch. 2023, 202358. doi:10.3762/bxiv.2023.58.v1
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