Supporting Information
Experimental procedures and analytical data, including copies of 1H, 13C and 31P NMR spectra (where appropriate) for all new compounds as well as details for oligonucleotide synthesis and thermal melting experiments.
| Supporting Information File 1: Experimental part. | ||
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Cite the Following Article
Structure/affinity studies in the bicyclo-DNA series: Synthesis and properties of oligonucleotides containing bcen-T and iso-tricyclo-T nucleosides
Branislav Dugovic, Michael Wagner and Christian J. Leumann
Beilstein J. Org. Chem. 2014, 10, 1840–1847.
https://doi.org/10.3762/bjoc.10.194
How to Cite
Dugovic, B.; Wagner, M.; Leumann, C. J. Beilstein J. Org. Chem. 2014, 10, 1840–1847. doi:10.3762/bjoc.10.194
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Scholarly Works
- Shi, Y.; Zhen, X.; Zhang, Y.; Li, Y.; Koo, S.; Saiding, Q.; Kong, N.; Liu, G.; Chen, W.; Tao, W. Chemically Modified Platforms for Better RNA Therapeutics. Chemical reviews 2024, 124, 929–1033. doi:10.1021/acs.chemrev.3c00611
- Frei, S.; Istrate, A.; Leumann, C. J. 6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations. Beilstein journal of organic chemistry 2018, 14, 3088–3097. doi:10.3762/bjoc.14.288
- Istrate, A.; Katolik, A.; Istrate, A.; Leumann, C. J. 2′β‐Fluoro‐Tricyclo Nucleic Acids (2′F‐tc‐ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation. Chemistry (Weinheim an der Bergstrasse, Germany) 2017, 23, 10310–10318. doi:10.1002/chem.201701476
- Jakhlal, J.; Coantic-Castex, S.; Denhez, C.; Petermann, C.; Martinez, A.; Harakat, D.; Guillaume, D.; Clivio, P. 5′- vs. 3′-end sugar conformational control in shaping up dinucleotides. Chemical communications (Cambridge, England) 2015, 51, 12381–12383. doi:10.1039/c5cc04212g
- Cleaves, H. J.; Meringer, M.; Goodwin, J. T. 227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?. Astrobiology 2015, 15, 538–558. doi:10.1089/ast.2014.1213
- Istrate, A.; Medvecky, M.; Leumann, C. J. 2'-Fluorination of tricyclo-DNA controls furanose conformation and increases RNA affinity. Organic letters 2015, 17, 1950–1953. doi:10.1021/acs.orglett.5b00662
- Medvecky, M.; Istrate, A.; Leumann, C. J. Synthesis and Properties of 6′-Fluoro-tricyclo-DNA. The Journal of organic chemistry 2015, 80, 3556–3565. doi:10.1021/acs.joc.5b00184
Patents
- LEUMANN CHRISTIAN; EVÉQUOZ DAMIEN. Bicyclic nucleosides and oligomers prepared therefrom. US 11919922 B2, March 5, 2024.
- LEUMANN CHRISTIAN; EVÉQUOZ DAMIEN. Bicyclic nucleosides and oligomers prepared therefrom. US 11028117 B2, June 8, 2021.
