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Using generative AI to transform peptide hits into small molecule leads
- Joshua Mills and
- Yu Heng Lau
Beilstein J. Org. Chem. 2026, 22, 672–679, doi:10.3762/bjoc.22.51
Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions
- Egor N. Boronin,
- Svetlana E. Kaurkina,
- Milena M. Svetlakova,
- Anton S. Bolshakov,
- Maxim V. Arsenyev,
- Vasilii F. Otvagin,
- Alexey Yu. Fedorov,
- Timothy Noël and
- Alexander V. Nyuchev
Beilstein J. Org. Chem. 2026, 22, 662–671, doi:10.3762/bjoc.22.50
Advantages of PROTACs in achieving selective degradation of homologous protein families
- Luxi Yang,
- Xinfei Mao,
- Jingyi Zhang,
- Jing Shu,
- Wenhai Huang,
- Xiaowu Dong,
- Yinqiao Chen and
- Mingfei Wu
Beilstein J. Org. Chem. 2026, 22, 628–661, doi:10.3762/bjoc.22.49
Hydrogen production from formic acid catalyzed by NHC–Cu complexes
- Orlando Santoro and
- Catherine S. J. Cazin
Beilstein J. Org. Chem. 2026, 22, 620–627, doi:10.3762/bjoc.22.48
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs
- Sophie Day-Riley,
- Sona Krajcovicova,
- Aryaman Raj Sokhal,
- Jan L. Venne,
- Paul Brear,
- Marko Hyvönen,
- Benjamin C. Whitehurst,
- Jason S. Carroll and
- David R. Spring
Beilstein J. Org. Chem. 2026, 22, 611–619, doi:10.3762/bjoc.22.47
Computational prediction of C–H hydricities and their use in predicting the regioselectivity of electron-rich C–H functionalisation reactions
- Rasmus M. Borup,
- Nicolai Ree and
- Jan H. Jensen
Beilstein J. Org. Chem. 2026, 22, 603–610, doi:10.3762/bjoc.22.46
Regioselective approach to 5-arylsulfonylisoxazoles and their antimicrobial activity
- Artem S. Sazonov,
- Dmitry A. Vasilenko,
- Denis V. Porfiriev,
- Yuri K. Grishin,
- Rimma A. Gazzaeva,
- Alisa P. Chernyshova,
- Maxim A. Kryakvin,
- Anna A. Baranova,
- Vera A. Alferova and
- Elena B. Averina
Beilstein J. Org. Chem. 2026, 22, 592–602, doi:10.3762/bjoc.22.45
Design and synthesis of an erdafitinib-based selective FGFR2 degrader
- Yumeng Jin,
- Shidong Wang,
- Sihan Pan,
- Shuqi Huang,
- Weichen Zhou,
- Xiaohao Huang,
- Lei Zheng and
- Lingfeng Chen
Beilstein J. Org. Chem. 2026, 22, 583–591, doi:10.3762/bjoc.22.44
Continuous-flow carbonyl hydrogenation under subatmospheric to atmospheric hydrogen pressure enabled by robust heterogeneous Pt–Fe catalysts
- Hiroyuki Miyamura,
- Ryosuke Kajiyama,
- Shun-ya Onozawa,
- Yoshihiro Kon and
- Shū Kobayashi
Beilstein J. Org. Chem. 2026, 22, 575–582, doi:10.3762/bjoc.22.43
Kinetic resolution of racemic planar-chiral vinylcymantrenes by molybdenum-catalyzed asymmetric metathesis dimerization
- Haruna Imazu,
- Hitoshi Izu,
- Yasuhiro Ohki and
- Masamichi Ogasawara
Beilstein J. Org. Chem. 2026, 22, 568–574, doi:10.3762/bjoc.22.42
