An efficient synthesis of N-substituted 3-nitrothiophen-2-amines

Scholarly Works

• Abedinifar, F.; Larijani, B.; Mahdavi, M. Nitroenediamines (EDAMs), and N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) derivatives: scaffolds for heterocycle molecular diversity (update from 2012 to 2021). RSC advances 2022, 12, 30436–30456. doi:10.1039/d2ra05547c
• Szlachcic, P.; Uchacz, T.; Gryl, M.; Danel, A.; Wojtasik, K.; Kolek, P.; Jarosz, B.; Stadnicka, K. Combined XRD and DFT studies towards understanding the impact of intramolecular H-bonding on the reductive cyclization process in pyrazole derivatives. Journal of Molecular Structure 2020, 1200, 127087. doi:10.1016/j.molstruc.2019.127087
• Kalpana, B.; Nanthini, R. Synthesis, Characterization and in vitro Antimicrobial, Antioxidant and Anticancer Activity of Random Copolyester Using 1,4-Dithiane-2,5-diol. Asian Journal of Chemistry 2019, 31, 2341–2344. doi:10.14233/ajchem.2019.21997
• Saigal, S.; Khan, S.; Rahman, H.; Shafiullah, S.; Khan, M. NitroketeneN,S-acetals: synergistic building blocks for the synthesis of heterocycles. RSC advances 2019, 9, 14477–14502. doi:10.1039/c9ra00630c
• Isadora, S. L.; da Cruz Rayssa, M. D.; da Cruz Ryldene Marques, D.; de Araújo Rodrigo, S. A.; Francisco, J. B. M.-J. 1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles. Current Organic Synthesis 2018, 15, 1026–1042. doi:10.2174/1570179415666180821154551
• Przybylski, P.; Pyta-Klich, K.; Pyta, K.; Janas, A. Cascade reactions as efficient and universal tools for construction and modification of 6-, 5-, 4- and 3-membered sulfur heterocycles of biological relevance. Tetrahedron 2018, 74, 6335–6365. doi:10.1016/j.tet.2018.09.022
• Liu, Z.; Wu, P.; He, Y.; Yang, T.; Yu, Z. [4+1] Cycloaddition of Enaminothiones and Aldehyde N‐Tosylhydrazones Toward 3‐Aminothiophenes. Advanced Synthesis & Catalysis 2018, 360, 4381–4392. doi:10.1002/adsc.201801028
• Sajadikhah, S. S.; Maghsoodlou, M. T. 1,4-DITHIANE-2,5-DIOL IN THE SYNTHESIS OF THIOPHENES (MICROREVIEW). Chemistry of Heterocyclic Compounds 2018, 54, 581–583. doi:10.1007/s10593-018-2309-8
• Maheswari, S. U.; Kumar, S. V.; Muthusubramanian, S.; Perumal, S. A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines. Molecular diversity 2018, 23, 75–84. doi:10.1007/s11030-018-9847-y
• Zamberlan, F.; Fantinati, A.; Trapella, C. 1,4‐Dithiane‐2,5‐diol: An Attractive Platform for the Synthesis of Sulfur Containing Functionalized Heterocycles. European Journal of Organic Chemistry 2018, 2018, 3248–3264. doi:10.1002/ejoc.201701785
• Yu, J.; Yu, L.-m.; Zhao, X.; Gan, L.; Zhu, W.-w.; Wang, Z.-c.; Wang, R.; Jiang, X. Organocatalytic asymmetric [3 + 2] annulation of 1,4-dithiane-2,5-diol with azlactones: access to chiral dihydrothiophen-2(3H)-one derivatives. Organic Chemistry Frontiers 2018, 5, 2040–2044. doi:10.1039/c8qo00305j
• Bharkavi, C.; Kumar, S. V.; Ali, M. A.; Osman, H.; Muthusubramanian, S.; Perumal, S. One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE. Bioorganic & medicinal chemistry letters 2017, 27, 3071–3075. doi:10.1016/j.bmcl.2017.05.050
• Bharkavi, C.; Kumar, S. V.; Ali, M. A.; Osman, H.; Muthusubramanian, S.; Perumal, S. A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities. Bioorganic & medicinal chemistry 2016, 24, 5873–5883. doi:10.1016/j.bmc.2016.09.044
• Kumara, C. S. P.; Gowda, G. B.; Kumar, K. V.; Ramesh, N.; Sadashiva, M. P.; Junjappa, H. Base catalyzed reaction of 1,4-dithiane-2,5-diol with α-oxoketene dithioacetals: a new general method for the synthesis of 2-methylthio-3-aroyl/heteroaroyl thiophenes. Tetrahedron Letters 2016, 57, 4302–4305. doi:10.1016/j.tetlet.2016.08.033
• Kumar, S. V.; Muthusubramanian, S.; Menéndez, J. C.; Perumal, S. An Efficient Synthesis of N-Substituted 3-Nitrothiophen-2-amines. ChemInform 2015, 46. doi:10.1002/chin.201550117

Explore citations to this article at