Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors

Scholarly Works

• Polterauer, D.; Roberge, D. M.; Hanselmann, P.; Littich, R.; Hone, C. A.; Kappe, C. O. A continuous flow investigation of sulfonyl chloride synthesis using N-chloroamides: optimization, kinetics and mechanism. Reaction Chemistry & Engineering 2022, 7, 2582–2592. doi:10.1039/d2re00280a
• Engbers, S.; Hage, R.; Klein, J. E. M. N. Toward Environmentally Benign Electrophilic Chlorinations: From Chloroperoxidase to Bioinspired Isoporphyrins. Inorganic chemistry 2022, 61, 8105–8111. doi:10.1021/acs.inorgchem.2c00602
• Steiner, A.; de Frutos, O.; Rincón, J. A.; Mateos, C.; Williams, J. D.; Kappe, C. O. N-Chloroamines as substrates for metal-free photochemical atom-transfer radical addition reactions in continuous flow. Reaction Chemistry & Engineering 2021, 6, 2434–2441. doi:10.1039/d1re00429h
• Sivo, A.; Galaverna, R.; Gomes, G. R.; Pastre, J. C.; Vilé, G. From circular synthesis to material manufacturing: advances, challenges, and future steps for using flow chemistry in novel application area. Reaction Chemistry & Engineering 2021, 6, 756–786. doi:10.1039/d0re00411a
• Gill, K. K.; Gibson, R.; Yiu, K. H. C.; Hester, P.; Reis, N. M. Microcapillary film reactor outperforms single-bore mesocapillary reactors in continuous flow chemical reactions. Chemical Engineering Journal 2021, 408, 127860. doi:10.1016/j.cej.2020.127860
• Zhu, Z.; Wang, Z.; Jian, Y.; Sun, H.; Zhang, G.; Lynam, J. M.; McElroy, C. R.; Burden, T. J.; Inight, R. L.; Fairlamb, I. J. S.; Zhang, W.; Gao, Z. Pd-Catalysed carbonylative Suzuki–Miyaura cross-couplings using Fe(CO) 5 under mild conditions: generation of a highly active, recyclable and scalable ‘Pd–Fe’ nanocatalyst. Green Chemistry 2021, 23, 920–926. doi:10.1039/d0gc03036h
• Jolley, K. E.; Chapman, M. R.; Blacker, A. J. A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines. Beilstein journal of organic chemistry 2018, 14, 2220–2228. doi:10.3762/bjoc.14.196
• Cosgrove, S. C.; Douglas, G. E.; Raw, S. A.; Marsden, S. P. Continuous Flow for the Photochemical C‐H Amination of Arenes. ChemPhotoChem 2018, 2, 851–854. doi:10.1002/cptc.201800105
• Chapman, M. R.; Kwan, M. H. T.; King, G. E.; Jolley, K. E.; Hussain, M.; Hussain, S.; Salama, I. E.; Niño, C. G.; Thompson, L. A.; Bayana, M. E.; Clayton, A. D.; Nguyen, B. N.; Turner, N. J.; Kapur, N.; Blacker, A. J. Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times. Organic Process Research & Development 2017, 21, 1294–1301. doi:10.1021/acs.oprd.7b00173
• Cantillo, D.; Kappe, C. O. Halogenation of organic compounds using continuous flow and microreactor technology. Reaction Chemistry & Engineering 2017, 2, 7–19. doi:10.1039/c6re00186f

Explore citations to this article at