Recent highlights in biosynthesis research using stable isotopes

Scholarly Works

• Liebergesell, T. C. E.; Murdock, E. G.; Puri, A. W. Detection of Inverse Stable Isotopic Labeling in Untargeted Metabolomic Data. Analytical chemistry 2024, 96, 16330–16337. doi:10.1021/acs.analchem.4c03528
• Leone, F.; Imfeld, A.; Mirzaei, Y.; Gélinas, Y. Using 13C enriched acetate in isotope labelling incubation experiments: a note of caution. Isotopes in environmental and health studies 2023, 60, 66–73. doi:10.1080/10256016.2023.2291460
• Morgan, K. D. The use of nitrogen-15 in microbial natural product discovery and biosynthetic characterization. Frontiers in microbiology 2023, 14, 1174591. doi:10.3389/fmicb.2023.1174591
• Zill, N. A.; Du, Y.; Marinkovich, S.; Gu, D.; Seidel, J.; Zhang, W. Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity Screening. ACS chemical biology 2023, 18, 1192–1199. doi:10.1021/acschembio.3c00083
• Zill, N.; Du, Y.; Marinkovich, S.; Gu, D.; Seidel, J.; Zhang, W. Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity Screening. Cold Spring Harbor Laboratory 2023. doi:10.1101/2023.03.16.532988
• Hou, A.; Dickschat, J. S. Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides. Natural product reports 2023, 40, 470–499. doi:10.1039/d2np00071g
• Shinada, T.; Nakayama, A.; Okamura, H.; Yasuno, Y. Recent Progress in the Synthesis of Deuterated Aldehyde. Bulletin of the Chemical Society of Japan 2022, 95, 1461–1473. doi:10.1246/bcsj.20220202
• Seidl, B.; Schuhmacher, R.; Bueschl, C. CPExtract, a Software Tool for the Automated Tracer-Based Pathway Specific Screening of Secondary Metabolites in LC-HRMS Data. Analytical chemistry 2022, 94, 3543–3552. doi:10.1021/acs.analchem.1c04530
• Seidl, B.; Schuhmacher, R.; Bueschl, C. CPExtract, a Software for the Automated Tracer-Based Pathway Specific Screening of Secondary Metabolites in LC-HRMS Data. Cold Spring Harbor Laboratory 2021. doi:10.1101/2021.10.20.465085
• Lecomte, M.; Lahboubi, M.; Thilmany, P.; Bouzakhi, A. E.; Evano, G. A general, versatile and divergent synthesis of selectively deuterated amines. Chemical science 2021, 12, 11157–11165. doi:10.1039/d1sc02622d
• Okamura, H.; Yasuno, Y.; Nakayama, A.; Kumadaki, K.; Kitsuwa, K.; Ozawa, K.; Tamura, Y.; Yamamoto, Y.; Shinada, T. Selective oxidation of alcohol-d1 to aldehyde-d1 using MnO2. RSC advances 2021, 11, 28530–28534. doi:10.1039/d1ra05405h
• Cummings, D. A.; Snelling, A. I.; Puri, A. W. Methylotroph Quorum Sensing Signal Identification by Inverse Stable Isotopic Labeling. ACS chemical biology 2021, 16, 1332–1338. doi:10.1021/acschembio.1c00329
• Hashiguchi, T.; Hashiguchi, M.; Tanaka, H.; Fukushima, K.; Gondo, T.; Akashi, R. Quantitative analysis of seven plant hormones in Lotus japonicus using standard addition method. PloS one 2021, 16, e0247276. doi:10.1371/journal.pone.0247276
• Shinada, T. Biosynthetic Reaction Mechanism of Terpene Synthases by Using Deuterium Labelled Acyclic Terpenes. Journal of Synthetic Organic Chemistry, Japan 2020, 78, 952–961. doi:10.5059/yukigoseikyokaishi.78.952
• Li; Qin, Z.; Radosevich, A. T. P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C-N Coupling with Nitromethane as a Methylamine Surrogate. Journal of the American Chemical Society 2020, 142, 16205–16210. doi:10.1021/jacs.0c08035
• Ramos-Figueroa, J. S.; Aamudalapalli, H. B.; Jagdhane, R. C.; Smith, J.; Palmer, D. R. J. Preparation and Application of 13C-Labeled myo-Inositol to Identify New Catabolic Products in Inositol Metabolism in Lactobacillus casei. Biochemistry 2020, 59, 2974–2985. doi:10.1021/acs.biochem.0c00539
• Wenski, S. L.; Cimen, H.; Berghaus, N.; Fuchs, S. W.; Hazir, S.; Bode, H. B. Fabclavine diversity in Xenorhabdus bacteria. Beilstein journal of organic chemistry 2020, 16, 956–965. doi:10.3762/bjoc.16.84
• Rios, N.; Radi, R.; Kalyanaraman, B.; Zielonka, J. Tracking isotopically labeled oxidants using boronate-based redox probes. The Journal of biological chemistry 2020, 295, 6665–6676. doi:10.1074/jbc.ra120.013402
• Fu, P. Use of Isotope Labels for NMR and MS Studies in Natural Products. Comprehensive Natural Products III; Elsevier, 2020; pp 3–13. doi:10.1016/b978-0-12-409547-2.14801-2
• Louie, K. B.; Kosina, S. M.; Hu, Y.; Otani, H.; de Raad, M.; Kuftin, A.; Mouncey, N. J.; Bowen, B. P.; Northen, T. R. Mass Spectrometry for Natural Product Discovery. Comprehensive Natural Products III; Elsevier, 2020; pp 263–306. doi:10.1016/b978-0-12-409547-2.14834-6

Explore citations to this article at