Influence of length and flexibility of spacers on the binding affinity of divalent ligands

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• Kang, J. J.; Ohoka, A.; Sarkar, C. A. Designing Multivalent and Multispecific Biologics. Annual review of chemical and biomolecular engineering 2023, 15, 293–314. doi:10.1146/annurev-chembioeng-100722-112440
• Ye, X.; Gaucher, J.-F.; Hu, H.; Wang, L.; Broussy, S. Dimer Peptide Ligands of Vascular Endothelial Growth Factor: Optimizing Linker Length for High Affinity and Antiangiogenic Activity. Journal of medicinal chemistry 2023, 66, 9753–9765. doi:10.1021/acs.jmedchem.3c00561
• Gerling-Driessen, U. I. M.; Hoffmann, M.; Schmidt, S.; Snyder, N. L.; Hartmann, L. Glycopolymers against pathogen infection. Chemical Society reviews 2023, 52, 2617–2642. doi:10.1039/d2cs00912a
• Ebrahimi, F.; Hosseinimehr, S. J. Homomultimer Strategy for Improvement of Radiolabeled Peptides and Antibody Fragments in Tumor Targeting. Current medicinal chemistry 2022, 29, 4923–4957. doi:10.2174/0929867329666220420131836
• Marlin, A.; Hierlmeier, I.; Guillou, A.; Bartholomä, M.; Tripier, R.; Patinec, V. Bioconjugated chelates based on (methylpyridinyl)tacn: synthesis, 64Cu labeling and in vitro evaluation for prostate cancer targeting. Metallomics : integrated biometal science 2022, 14. doi:10.1093/mtomcs/mfac036
• Kjaergaard, M. Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles. Biochemistry 2022, 61, 171–182. doi:10.1021/acs.biochem.1c00737
• Tom, J. K.; Deniz, A. A. Complex dynamics of multicomponent biological coacervates. Current Opinion in Colloid & Interface Science 2021, 56, 101488. doi:10.1016/j.cocis.2021.101488
• Hahn, D.; Sonntag, J. M.; Lück, S.; Maitz, M. F.; Freudenberg, U.; Jordan, R.; Werner, C. Poly(2-alkyl-2-oxazoline)-Heparin Hydrogels-Expanding the Physicochemical Parameter Space of Biohybrid Materials. Advanced healthcare materials 2021, 10, 2101327. doi:10.1002/adhm.202101327
• Kjaergaard, M. Estimation of effective concentrations enforced by complex linker architectures using conformational ensembles. Cold Spring Harbor Laboratory 2021. doi:10.1101/2021.08.13.456233
• Janssen, M.; Stenmark, H.; Carlson, A. Divalent ligand-monovalent molecule binding. Soft matter 2021, 17, 5375–5383. doi:10.1039/d1sm00070e
• Janssen, M.; Stenmark, H.; Carlson, A. Divalent ligand-monovalent molecule binding. Cold Spring Harbor Laboratory 2021. doi:10.1101/2021.01.14.426724
• Hajduch, J.; Fabre, B.; Klopp, B.; Pohl, R.; Buděšínský, M.; Šolínová, V.; Kašička, V.; Köprülüoğlu, C.; Eyrilmez, S. M.; Lepšík, M.; Hobza, P.; Mitrová, K.; Lubos, M.; Hernández, M. S. G.; Jiráček, J. Multipodal insulin mimetics built on adamantane or proline scaffolds. Bioorganic chemistry 2020, 107, 104548. doi:10.1016/j.bioorg.2020.104548
• Heida, R.; Bhide, Y.; Gasbarri, M.; Kocabiyik, O.; Stellacci, F.; Huckriede, A.; Hinrichs, W. L. J.; Frijlink, H. W. Advances in the development of entry inhibitors for sialic-acid-targeting viruses. Drug discovery today 2020, 26, 122–137. doi:10.1016/j.drudis.2020.10.009
• Zumbro, E.; Alexander-Katz, A. Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation. Biophysical journal 2020, 119, 1849–1864. doi:10.1016/j.bpj.2020.09.035
• Johansson, E.; Caraballo, R.; Mistry, N.; Zocher, G.; Qian, W.; Andersson, C. D.; Hurdiss, D. L.; Chandra, N.; Thompson, R. F.; Frängsmyr, L.; Stehle, T.; Arnberg, N.; Elofsson, M. Pentavalent Sialic Acid Conjugates Block Coxsackievirus A24 Variant and Human Adenovirus Type 37–Viruses That Cause Highly Contagious Eye Infections. ACS chemical biology 2020, 15, 2683–2691. doi:10.1021/acschembio.0c00446
• Bachem, G.; Wamhoff, E.-C.; Silberreis, K.; Kim, D.; Baukmann, H.; Fuchsberger, F. F.; Dernedde, J.; Rademacher, C.; Seitz, O. Rational Design of a DNA-Scaffolded High-Affinity Binder for Langerin. Angewandte Chemie (International ed. in English) 2020, 59, 21016–21022. doi:10.1002/anie.202006880
• Bachem, G.; Wamhoff, E.; Silberreis, K.; Kim, D.; Baukmann, H.; Fuchsberger, F.; Dernedde, J.; Rademacher, C.; Seitz, O. Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin. Angewandte Chemie 2020, 132, 21202–21208. doi:10.1002/ange.202006880
• Kumar, H. M. S.; Herrmann, L.; Tsogoeva, S. B. Structural hybridization as a facile approach to new drug candidates. Bioorganic & medicinal chemistry letters 2020, 30, 127514. doi:10.1016/j.bmcl.2020.127514
• Mohtavinejad, N.; Ardestani, M. S.; Khalaj, A.; Pormohammad, A.; Najafi, R.; Bitarafan-Rajabi, A.; Hajiramezanali, M.; Amanlou, M. Application of radiolabeled peptides in tumor imaging and therapy. Life sciences 2020, 258, 118206. doi:10.1016/j.lfs.2020.118206

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