Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

Scholarly Works

• Winter, A. J.; de Courcy‐Ireland, F.; Phillips, A. P.; Barker, J. M.; Bakar, N. A.; Akter, N.; Wang, L.; Song, Z.; Crosby, J.; Williams, C.; Willis, C. L.; Crump, M. P. An Integrated Module Performs Selective 'Online' Epoxidation in the Biosynthesis of the Antibiotic Mupirocin. Angewandte Chemie 2024. doi:10.1002/ange.202410502
• Roß-Taschner, T.; Derra, S.; Stang, J.; Schlotte, L.; Putratama, A.; Hahn, F. Highly Stereoselective Biocatalytic One-Pot Synthesis of Chiral Saturated Oxygen Heterocycles by Integration of a Biosynthetic Heterocyclase into Multiple-Enzyme Cascades. ACS Catalysis 2024, 14, 13420–13428. doi:10.1021/acscatal.4c03692
• Winter, A. J.; de Courcy-Ireland, F.; Phillips, A. P.; Barker, J. M.; Bakar, N. A.; Akter, N.; Wang, L.; Song, Z.; Crosby, J.; Williams, C.; Willis, C. L.; Crump, M. P. An Integrated Module Performs Selective 'Online' Epoxidation in the Biosynthesis of the Antibiotic Mupirocin. Angewandte Chemie (International ed. in English) 2024, e202410502. doi:10.1002/anie.202410502
• Xu, B.; Wang, Q.; Fang, C.; Zhang, Z.-M.; Zhang, J. Recent advances in Pd-catalyzed asymmetric cyclization reactions. Chemical Society reviews 2024, 53, 883–971. doi:10.1039/d3cs00489a
• Arzine, A.; Abchir, O.; Chalkha, M.; Chebbac, K.; Rhazi, Y.; Barghady, N.; Yamari, I.; El Moussaoui, A.; Nakkabi, A.; Akhazzane, M.; Bakhouch, M.; Chtita, S.; El Yazidi, M. Design, synthesis, In-vitro, In-silico and DFT studies of novel functionalized isoxazoles as antibacterial and antioxidant agents. Computational biology and chemistry 2023, 108, 107993. doi:10.1016/j.compbiolchem.2023.107993
• Mancuso, R.; De Salvo, A.; Russo, P.; Falcicchio, A.; Ca', N. D.; Munoz, L. P.; Gabriele, B. Palladium Iodide‐Catalyzed Selective Carbonylative Double Cyclization of 4‐(2‐Aminophenyl)‐3‐yn‐1‐ols to Dihydrofuroquinolinone Derivatives. Chinese Journal of Chemistry 2023, 41, 2801–2809. doi:10.1002/cjoc.202300277
• Derra, S.; Schlotte, L.; Hahn, F. Suzuki–Miyaura Reaction in the Presence of N-Acetylcysteamine Thioesters Enables Rapid Synthesis of Biomimetic Polyketide Thioester Surrogates for Biosynthetic Studies. Chemistry 2023, 5, 1407–1418. doi:10.3390/chemistry5020096
• Yang, C.; Hu, S.; Pan, X.; Yang, K.; Zhang, K.; Liu, Q.; Xin, X.; Li, J.; Wang, J.; Yang, X. Novel Synthesis of Dihydroisoxazoles by p-TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones. Molecules (Basel, Switzerland) 2023, 28, 2565. doi:10.3390/molecules28062565
• Ziani, B. E. C.; Mohamed, A.; Ziani, C.; Saher, L. Polyketides. Natural Secondary Metabolites; Springer International Publishing, 2023; pp 201–284. doi:10.1007/978-3-031-18587-8_7
• Winand, L.; Theisen, S.; Lütz, S.; Rosenthal, K.; Nett, M. Immobilization of the Amidohydrolase MxcM and Its Application for Biocatalytic Flow Synthesis of Pseudochelin A. Catalysts 2023, 13, 229. doi:10.3390/catal13020229
• Majhi, S. Applications of nanoparticles in organic synthesis under ultrasonication. Nanoparticles in Green Organic Synthesis; Elsevier, 2023; pp 279–315. doi:10.1016/b978-0-323-95921-6.00014-7
• Winand, L.; Lernoud, L.; Meyners, S. A.; Kuhr, K.; Hiller, W.; Nett, M. Myxococcus xanthus as Host for the Production of Benzoxazoles. Chembiochem : a European journal of chemical biology 2022, 24, e202200635. doi:10.1002/cbic.202200635
• Wagner, L.; Stang, J.; Derra, S.; Hollmann, T.; Hahn, F. Towards understanding oxygen heterocycle-forming biocatalysts: a selectivity study of the pyran synthase PedPS7. Organic & biomolecular chemistry 2022, 20, 9645–9649. doi:10.1039/d2ob02064e
• Wu, H.; Lu, X.; Xu, J.; Zhang, X.; Li, Z.; Yang, X.; Ling, Y. Design, Synthesis and Fungicidal Activity of N-(thiophen-2-yl) Nicotinamide Derivatives. Molecules (Basel, Switzerland) 2022, 27, 8700. doi:10.3390/molecules27248700
• Lu, J.; Yao, B.; Zhan, D.; Sun, Z.; Ji, Y.; Zhang, X. One-pot double annulations to confer diastereoselective spirooxindolepyrrolothiazoles. Beilstein journal of organic chemistry 2022, 18, 1607–1616. doi:10.3762/bjoc.18.171
• Zeng, M.; Xue, Y.; Qin, Y.; Peng, F.; Li, Q.; Zeng, M.-H. CuBr-promoted domino Biginelli reaction for the diastereoselective synthesis of bridged polyheterocycles: Mechanism studies and in vitro anti-tumor activities. Chinese Chemical Letters 2022, 33, 4891–4895. doi:10.1016/j.cclet.2022.02.075
• Mancuso, R.; Russo, P.; Miliè, R.; Dell’Aera, M.; Grande, F.; Della Ca, N.; Gabriele, B. Palladium iodide catalyzed carbonylative double cyclization to a new class of S,O-bicyclic heterocycles. Catalysis Today 2022, 397-399, 631–638. doi:10.1016/j.cattod.2021.05.011
• Takeuchi, Y.; Kawasaki, S.; Akagawa, K.; Kudo, K. Iterative synthesis of nitrogen-containing polyketide via oxime intermediates. RSC advances 2022, 12, 5275–5279. doi:10.1039/d2ra00108j
• Bowen, J. I.; Wang, L.; Crump, M. P.; Willis, C. L. Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans. Organic & biomolecular chemistry 2022, 20, 1150–1175. doi:10.1039/d1ob01905h
• Gao, B.; Yang, B.; Feng, X.; Li, C. Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products. Natural product reports 2022, 39, 139–162. doi:10.1039/d1np00017a

Explore citations to this article at