Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa

Scholarly Works

• Vieira, T. F.; Cerqueira, N. M. F. S. A.; Simões, M.; Sousa, S. F. In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa. Molecular Systems Design & Engineering 2024, 9, 7–19. doi:10.1039/d3me00107e
• Szamosvári, D.; Savchenko, V.; Badouin, N.; Böttcher, T. Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif. Organic & biomolecular chemistry 2023, 21, 5158–5163. doi:10.1039/d3ob00710c
• Empting, M. Quo vadis quorum sensing? Advances in disrupting the Pseudomonas quinolone signal (PQS). New Approaches Towards Novel Antibacterial Agents; Elsevier, 2023; pp 135–159. doi:10.1016/bs.armc.2023.09.004
• Li; Peng, X.; Guo, Y.; Gong, S.; Cao, S.; Qiu, F. Currently Available Strategies for Target Identification of Bioactive Natural Products. Frontiers in chemistry 2021, 9, 761609. doi:10.3389/fchem.2021.761609
• Prothiwa, M.; Filz, V.; Oehler, S. R.; Böttcher, T. Inhibiting quinolone biosynthesis of Burkholderia. Chemical science 2021, 12, 6908–6912. doi:10.1039/d0sc06167k
• Pawar, A.; Basler, M.; Goebel, H.; Salinas, G. O. A.; Groettrup, M.; Böttcher, T. Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome. ACS central science 2020, 6, 241–246. doi:10.1021/acscentsci.9b01170
• Dong, X.; Liu, H. 14.4.13 4H-1-Benzopyran-4-thiones (Update 2019). Knowledge Updates 2019/3; Georg Thieme Verlag KG, 2020. doi:10.1055/sos-sd-114-00172
• Prothiwa, M.; Böttcher, T. Competitive profiling for enzyme inhibitors using chemical probes. Methods in enzymology 2019, 633, 49–69. doi:10.1016/bs.mie.2019.10.031
• Modi, A.; Sau, P.; Chakraborty, N.; Patel, B. K. A “Thiocarbonyl‐Directed” Regiospecific C−H/S−H Annulation of Quinoline‐4(1 H )‐thiones with Alkynes. Advanced Synthesis & Catalysis 2019, 361, 1368–1375. doi:10.1002/adsc.201801537
• Prothiwa, M.; Englmaier, F.; Böttcher, T. Competitive Live-Cell Profiling Strategy for Discovering Inhibitors of the Quinolone Biosynthesis of Pseudomonas aeruginosa. Journal of the American Chemical Society 2018, 140, 14019–14023. doi:10.1021/jacs.8b07629
• Schütz, C.; Empting, M. Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers. Beilstein journal of organic chemistry 2018, 14, 2627–2645. doi:10.3762/bjoc.14.241
• Sharifzadeh, S.; Shirley, J. D.; Carlson, E. E. Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles. Current topics in microbiology and immunology 2018, 420, 23–48. doi:10.1007/82_2018_135
• Modi, A.; Sau, P.; Patel, B. K. Base-Promoted Synthesis of Quinoline-4(1H)-thiones from o-Alkynylanilines and Aroyl Isothiocyanates. Organic letters 2017, 19, 6128–6131. doi:10.1021/acs.orglett.7b02993
• Leichnitz, D.; Raguž, L.; Beemelmanns, C. Total synthesis and functional analysis of microbial signalling molecules. Chemical Society reviews 2017, 46, 6330–6344. doi:10.1039/c6cs00665e
• Kamal, A. A. M.; Maurer, C. K.; Allegretta, G.; Haupenthal, J.; Empting, M.; Hartmann, R. W. Quorum Sensing Inhibitors as Pathoblockers for Pseudomonas aeruginosa Infections: A New Concept in Anti-Infective Drug Discovery. Topics in Medicinal Chemistry; Springer International Publishing, 2017; pp 185–210. doi:10.1007/7355_2017_17

Explore citations to this article at