Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

Scholarly Works

• Adhikari, A.; Shakya, S.; Shrestha, S.; Aryal, D.; Timalsina, K. P.; Dhakal, D.; Khatri, Y.; Parajuli, N. Biocatalytic role of cytochrome P450s to produce antibiotics: A review. Biotechnology and bioengineering 2023, 120, 3465–3492. doi:10.1002/bit.28548
• Tian, L.; Shi, S.; Zhang, X.; Han, F.; Dong, H. Newest perspectives of glycopeptide antibiotics: biosynthetic cascades, novel derivatives, and new appealing antimicrobial applications. World journal of microbiology & biotechnology 2023, 39, 67. doi:10.1007/s11274-022-03512-0
• Greule, A.; Izoré, T.; Machell, D.; Hansen, M. H.; Schoppet, M.; De Voss, J. J.; Charkoudian, L. K.; Schittenhelm, R. B.; Harmer, J. R.; Cryle, M. J. The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage. Frontiers in chemistry 2022, 10, 868240. doi:10.3389/fchem.2022.868240
• Zhao, Y.; Ho, Y. T. C.; Tailhades, J.; Cryle, M. J. Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway. Chembiochem : a European journal of chemical biology 2020, 22, 43–51. doi:10.1002/cbic.202000309
• Greule, A.; Cryle, M. J. The Glycopeptide Antibiotics. Comprehensive Natural Products III; Elsevier, 2020; pp 247–283. doi:10.1016/b978-0-12-409547-2.14691-8
• Greule, A.; Izoré, T.; Iftime, D.; Tailhades, J.; Schoppet, M.; Zhao, Y.; Peschke, M.; Ahmed, I.; Kulik, A.; Adamek, M.; Goode, R. J. A.; Schittenhelm, R. B.; Kaczmarski, J. A.; Jackson, C. J.; Ziemert, N.; Krenske, E. H.; De Voss, J. J.; Stegmann, E.; Cryle, M. J. Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nature communications 2019, 10, 2613. doi:10.1038/s41467-019-10384-w
• Greule, A.; Stok, J. E.; De Voss, J. J.; Cryle, M. J. Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Natural product reports 2018, 35, 757–791. doi:10.1039/c7np00063d
• Brieke, C.; Tarnawski, M.; Greule, A.; Cryle, M. J. Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. Journal of inorganic biochemistry 2018, 185, 43–51. doi:10.1016/j.jinorgbio.2018.05.001
• Schoppet, M.; Tailhades, J.; Kulkarni, K.; Cryle, M. J. Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade?. The Journal of organic chemistry 2018, 83, 7206–7214. doi:10.1021/acs.joc.8b00418
• Tailhades, J.; Schoppet, M.; Greule, A.; Peschke, M.; Brieke, C.; Cryle, M. J. A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis. Chemical communications (Cambridge, England) 2018, 54, 2146–2149. doi:10.1039/c7cc09409d
• Peschke, M.; Brieke, C.; Heimes, M.; Cryle, M. J. The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones. ACS chemical biology 2017, 13, 110–120. doi:10.1021/acschembio.7b00943
• Rudolf, J. D.; Chang, C.-Y.; Ma, M.; Shen, B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural product reports 2017, 34, 1141–1172. doi:10.1039/c7np00034k
• Peschke, M.; Brieke, C.; Goode, R. J. A.; Schittenhelm, R. B.; Cryle, M. J. Chlorinated glycopeptide antibiotic peptide precursors improve cytochrome P450-catalyzed cyclization cascade efficiency. Biochemistry 2017, 56, 1239–1247. doi:10.1021/acs.biochem.6b01102
• Mollo, A.; von Krusenstiern, A. N.; Bulos, J. A.; Ulrich, V.; Åkerfeldt, K. S.; Cryle, M. J.; Charkoudian, L. K. P450 monooxygenase ComJ catalyses side chain phenolic cross-coupling during complestatin biosynthesis. RSC Adv. 2017, 7, 35376–35384. doi:10.1039/c7ra06518c

Explore citations to this article at