The chemistry and biology of mycolactones

Scholarly Works

• Nguyen, J. D. M.; da Hora, G. C. A.; Swanson, J. M. J. Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity. Toxins 2023, 15, 486. doi:10.3390/toxins15080486
• Ricci, D.; Demangel, C. From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone. Toxins 2023, 15, 369. doi:10.3390/toxins15060369
• S. Avumegah, M. <i>Mycobacterium ulcerans</i> Disease and Host Immune Responses. New Advances in Neglected Tropical Diseases; IntechOpen, 2023. doi:10.5772/intechopen.103843
• Domenger, A.; Ricci, D.; Mayau, V.; Majlessi, L.; Marcireau, C.; Dadaglio, G.; Demangel, C. Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma. Frontiers in oncology 2023, 13, 1110916. doi:10.3389/fonc.2023.1110916
• Komine, T.; Ihara, H.; Ono, K.; Yoshida, M.; Sugimoto, Y.; Inohana, M.; Fukano, H.; Kurata, O.; Wada, S. A case of mycobacteriosis associated with Mycobacterium pseudoshottsii in aquarium-reared fish in Japan. The Journal of veterinary medical science 2022, 84, 1617–1620. doi:10.1292/jvms.22-0318
• Komine, T.; Hyogo, I.; Kentaro, O.; Yoshida, M.; Sugimoto, Y.; Inohana, M.; Fukano, H.; Kurata, O.; Wada, S. A case of mycobacteriosis associated with Mycobacterium pseudoshottsii in aquarium-reared fish in Japan. Cold Spring Harbor Laboratory 2022. doi:10.1101/2022.07.14.500145
• Domenger, A.; Choisy, C.; Baron, L.; Mayau, V.; Perthame, E.; Deriano, L.; Arnulf, B.; Bories, J.-C.; Dadaglio, G.; Demangel, C. The Sec61 translocon is a therapeutic vulnerability in multiple myeloma. EMBO molecular medicine 2022, 14, e14740. doi:10.15252/emmm.202114740
• Foulon, M.; Fraga, A. G.; Yeramian, E.; Pedrosa, J.; Marsollier, L. Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans. Biology of Mycobacterial Lipids; Elsevier, 2022; pp 271–290. doi:10.1016/b978-0-323-91948-7.00008-7
• Bhadra, P.; Dos Santos, S. J.; Gamayun, I.; Pick, T.; Neumann, C.; Ogbechi, J.; Hall, B. S.; Zimmermann, R.; Helms, V.; Simmonds, R. E.; Cavalié, A. Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state. The Biochemical journal 2021, 478, 4005–4024. doi:10.1042/bcj20210345
• Rifflet, A.; Demangel, C.; Guenin-Macé, L. Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples. Methods in molecular biology (Clifton, N.J.) 2021, 2387, 117–130. doi:10.1007/978-1-0716-1779-3_13
• Röltgen, K.; Pluschke, G. Overview: Mycolactone , the Macrolide Toxin of Mycobacterium ulcerans. Methods in molecular biology (Clifton, N.J.) 2021, 2387, 105–108. doi:10.1007/978-1-0716-1779-3_11
• Domenger, A.; Choisy, C.; Baron, L.; Mayau, V.; Deriano, L.; Arnulf, B.; Bories, J.-C.; Dadaglio, G.; Demangel, C. The Sec61 translocon is a therapeutic vulnerability in Multiple Myeloma. Cold Spring Harbor Laboratory 2021. doi:10.1101/2021.09.05.459026
• Warryn, L.; Dangy, J.-P.; Gersbach, P.; Gehringer, M.; Altmann, K.-H.; Pluschke, G. An Antigen Capture Assay for the Detection of Mycolactone, the Polyketide Toxin of Mycobacterium ulcerans . Journal of immunology (Baltimore, Md. : 1950) 2021, 206, 2753–2762. doi:10.4049/jimmunol.2001232
• Bhadra, P.; Dos Santos, S.; Gamayun, I.; Pick, T.; Ogbechi, J.; Hall, B. S.; Zimmermann, R.; Helms, V.; Simmonds, R. E.; Cavalié, A. Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state. Cold Spring Harbor Laboratory 2021. doi:10.1101/2021.05.12.443793
• Demangel, C. Immunity against Mycobacterium ulcerans: The subversive role of mycolactone. Immunological reviews 2021, 301, 209–221. doi:10.1111/imr.12956
• Hammoudi, N.; Cassagne, C.; Million, M.; Ranque, S.; Kabore, O.; Drancourt, M.; Zingue, D.; Bouam, A. Investigation of skin microbiota reveals Mycobacterium ulcerans-Aspergillus sp. trans-kingdom communication. Scientific reports 2021, 11, 3777. doi:10.1038/s41598-021-83236-7
• Tan, L. T.-H.; Raghunath, P.; Ming, L. C.; Law, J. W.-F. Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment. Progress In Microbes & Molecular Biology 2020, 3. doi:10.36877/pmmb.a0000114
• Warryn, L.; Dangy, J.-P.; Gersbach, P.; Gehringer, M.; Schäfer, A.; Ruf, M.-T.; Ruggli, N.; Altmann, K.-H.; Pluschke, G. Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans. PLoS neglected tropical diseases 2020, 14, e0008357. doi:10.1371/journal.pntd.0008357
• Huang, J.-J.; Li, Y. X.; Zhao, Y.; Yang, W. H.; Xiao, M.; Kudinha, T.; Xu, Y. Prevalence of nontuberculous mycobacteria in a tertiary hospital in Beijing, China, January 2013 to December 2018. BMC microbiology 2020, 20, 1–8. doi:10.1186/s12866-020-01840-5
• Minnikin, D. E.; Brennan, P. J. Lipids of Clinically Significant Mycobacteria. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids; Springer International Publishing, 2020; pp 33–108. doi:10.1007/978-3-030-15147-8_7

Explore citations to this article at