Mechanochemical synthesis of small organic molecules

Scholarly Works

• Fatima, A.; Shahzadi, A.; Majeed, A.; Al-Rawi, S. S.; Ibrahim, A. H.; Iqbal, M. A.; Qaleel, F. Green Catalysis: Water as a Sustainable Medium in Organocatalyzed Reactions. Langmuir : the ACS journal of surfaces and colloids 2025. doi:10.1021/acs.langmuir.4c05355
• Wang, X.; Fukuzawa, Y.; Gao, P.; Jiang, J.; Maeda, S.; Kubota, K.; Ito, H. Direct arylation of gem-difluorostyrenes using in situ mechanochemically generated calcium-based heavy Grignard reagents. RSC Mechanochemistry 2025, 2, 256–262. doi:10.1039/d4mr00135d
• Yamamoto, T.; Kubota, K.; Harabuchi, Y.; Ito, H. Scaling theory for the kinetics of mechanochemical reactions with convective flow. RSC Mechanochemistry 2025, 2, 230–239. doi:10.1039/d4mr00091a
• Xu, P.; Li, M.-J.; Diao, H.; Shao, N.; He, Z.-Y.; Fan, S.-Z.; Zhang, Z.; Xu, H. Chemodivergent and diastereoselective synthesis of syn- and anti-cyclopentenyl spiroisoxazolones under ball-milling conditions. RSC Mechanochemistry 2025, 2, 317–321. doi:10.1039/d4mr00125g
• Becerra, D.; Castillo, J.-C. Recent advances in the synthesis of anticancer pyrazole derivatives using microwave, ultrasound, and mechanochemical techniques. RSC advances 2025, 15, 7018–7038. doi:10.1039/d4ra08866b
• Wang, J.; Yang, X.; Peng, C.; Pei, M.; Wei, X. Mechanochemical fluorination of unactivated tertiary alkyl chlorides. Green Chemistry 2025, 27, 2197–2202. doi:10.1039/d4gc05972g
• Kubota, K.; Makino, T.; Kondo, K.; Seo, T.; Jin, M.; Ito, H. Solid-state aromatic nucleophilic fluorination: a rapid, practical, and environmentally friendly route to N-heteroaryl fluorides. Green Chemistry 2025, 27, 1771–1776. doi:10.1039/d4gc06362g
• Li, M.-Y.; Gu, A.; Li, J.; Liu, Y. Advanced green synthesis: Solvent-free and catalyst-free reaction. Green Synthesis and Catalysis 2025, 6, 36–66. doi:10.1016/j.gresc.2024.11.001
• Dezotti, F.; Medrán, N. S.; Pellegrinet, S. C. Diels-Alder Reactions of Boron-Substituted Furans with N-Phenylmaleimide: Strategies for Tuning the Reactivity and Selectivity. The Journal of organic chemistry 2025, 90, 1460–1465. doi:10.1021/acs.joc.4c02671
• Gieling, J.; Wéry, G.; Lopes, C.; de Meester, J.; Brandel, C.; Cartigny, Y.; Leyssens, T.; Baier, D. M. Mechanochemical Deracemization: A Sustainable Approach to Enantiopurity. Chemistry (Weinheim an der Bergstrasse, Germany) 2025, 31, e202404120. doi:10.1002/chem.202404120
• Leon, F.; Reynes, J. F.; Shi, X.; García, F. Synthesis of Metal Complexes, MOFs and Inorganic Materials by Mechanochemistry. Encyclopedia of Green Chemistry; Elsevier, 2025; pp 504–531. doi:10.1016/b978-0-443-15742-4.00095-8
• Kubota, K.; Nagao, A.; Ito, H. Solvent-free zinc-mediated Béchamp reduction using mechanochemistry. RSC Mechanochemistry 2025. doi:10.1039/d4mr00138a
• Pattanayak, P.; Saha, S.; Chatterjee, T.; Ranu, B. C. Sustainable and solvent-free synthesis of molecules of pharmaceutical importance by ball milling. Chemical communications (Cambridge, England) 2024, 61, 247–265. doi:10.1039/d4cc05127k
• Gat, S.; Chatterjee, R.; Solanke, J.; Dhayalan, V.; Dandela, R. Mechanochemical Synthesis of Phosphoryl Amides and Esters from Diphenylphosphoryl Azides Under Mild Conditions. ChemistrySelect 2024, 9. doi:10.1002/slct.202404882
• Chaudhary, H. R.; Patel, D. M. New frontiers in multicomponent mechanosynthesis for organic molecules: modern marvels. Molecular diversity 2024. doi:10.1007/s11030-024-11053-x
• Sheikhaleslami, S.; Sperry, J. Mechanochemical Radical Transformations in Organic Synthesis. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 31, e202403833. doi:10.1002/chem.202403833
• Trzeciak, K.; Dudek, M. K.; Potrzebowski, M. J. Mechanochemical Transformations of Pharmaceutical Cocrystals: Polymorphs and Coformer Exchange. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202402683. doi:10.1002/chem.202402683
• Kubota, K.; Kawamura, S.; Jiang, J.; Maeda, S.; Ito, H. Mechanochemical generation of aryl barium nucleophiles from unactivated barium metal. Chemical science 2024, 15, 17453–17459. doi:10.1039/d4sc05361c
• Ferrario, M.; Righi, M. C. In Operando Formation of Layered Materials for Friction Reduction. NanoScience and Technology; Springer International Publishing, 2024; pp 299–314. doi:10.1007/978-3-031-63065-1_14
• Adak, L.; Roy, K.; Saha, A.; Sahoo, S.; Banerjee, S.; Mukhopadhyay, C. D.; Banerjee, S. Reaction under Ball-Milling: Solvent- and Metal-Free One-Pot Diastereoselective Synthesis of Tetrahydroquinoline Derivatives as Potential Antibacterial and Anticancer Agents. Synlett 2024, 35, 2487–2495. doi:10.1055/a-2378-1847

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