Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?

Scholarly Works

• Pawlas, J.; Rasmussen, J. H. Sustainable Approaches in Solid-phase Peptide Synthesis (SPPS). Sustainability in Tides Chemistry; Royal Society of Chemistry, 2024; pp 50–84. doi:10.1039/9781837674541-00050
• Verdoliva, V.; Bedini, E.; De Luca, S. Sustainable Chemical Modification of Natural Polysaccharides: Mechanochemical, Solvent-Free Conjugation of Pectins and Hyaluronic Acid Promoted by Microwave Radiations. Biomacromolecules 2024, 25, 6217–6228. doi:10.1021/acs.biomac.4c00844
• Bolt, R. R. A.; Smallman, H. R.; Leitch, J. A.; Bluck, G. W.; Barreteau, F.; Iosub, A. V.; Constable, D.; Dapremont, O.; Richardson, P.; Browne, D. L. Solvent Minimized Synthesis of Amides by Reactive Extrusion. Angewandte Chemie 2024, 136. doi:10.1002/ange.202408315
• Bolt, R. R. A.; Smallman, H. R.; Leitch, J. A.; Bluck, G. W.; Barreteau, F.; Iosub, A. V.; Constable, D.; Dapremont, O.; Richardson, P.; Browne, D. L. Solvent Minimized Synthesis of Amides by Reactive Extrusion. Angewandte Chemie (International ed. in English) 2024, 63, e202408315. doi:10.1002/anie.202408315
• Reynes, J. F.; Leon, F.; García, F. Mechanochemistry for Organic and Inorganic Synthesis. ACS organic & inorganic Au 2024, 4, 432–470. doi:10.1021/acsorginorgau.4c00001
• Juaristi, E. Some contributions to three relevant areas in organic stereochemistry during the last decade: (1) conformational effects, (2) asymmetric organocatalysis, and (3) mechanoenzymatic processes. Tetrahedron 2024, 162, 134129. doi:10.1016/j.tet.2024.134129
• Wróblewska, A.; Bak-Sypien, I. I.; Paluch, P.; Wielgus, E.; Zając, J.; Jeziorna, A.; Kaźmierski, S.; Potrzebowski, M. J. Solvent-Free Mechanosynthesis of Oligopeptides by Coupling Peptide Segments of Different Lengths - Elucidating the Role of Cesium Carbonate in Ball Mill Processes. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202400177. doi:10.1002/chem.202400177
• Mohy El‐Dine, T.; Lavayssiere, M.; Adihou, H.; Subra, G.; Métro, T.; Ludemann‐Hombourger, O.; Lamaty, F. Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame. ChemistryEurope 2024, 2. doi:10.1002/ceur.202400007
• Zhao, Z.; Ikawa, S.; Mori, S.; Sumii, Y.; Adachi, H.; Kagawa, T.; Shibata, N. Mechanochemical Deoxyfluorination of Carboxylic Acids to Acyl Fluorides and Successive Mechanochemical Amide Bond Formation. ACS Sustainable Chemistry & Engineering 2024, 12, 3565–3574. doi:10.1021/acssuschemeng.3c06417
• Verdoliva, V.; Digilio, G.; De Luca, S. Solid-State Strategy for the S-Conjugation of Peptides Catalyzed by Zeolites and Promoted by Microwave Radiation: A Green Approach. ACS Sustainable Chemistry & Engineering 2024, 12, 1809–1815. doi:10.1021/acssuschemeng.3c05902
• Huang, J.; Yang, Y.; Zhang, Z.; Liu, S. Recent Progress on Green Methods and Technologies for Efficient Formation of Amide Bonds. Chinese Journal of Organic Chemistry 2024, 44, 409. doi:10.6023/cjoc202309011
• Zeitler, S. M.; Golder, M. R. Shake, shear, and grind! - the evolution of mechanoredox polymerization methodology. Chemical communications (Cambridge, England) 2023, 60, 26–35. doi:10.1039/d3cc04323a
• Lennox, C. B.; Borchers, T. H.; Gonnet, L.; Barrett, C. J.; Koenig, S. G.; Nagapudi, K.; Friščić, T. Direct mechanocatalysis by resonant acoustic mixing (RAM). Chemical science 2023, 14, 7475–7481. doi:10.1039/d3sc01591b
• Juaristi, E.; Avila-Ortiz, C. G. Salient Achievements in Synthetic Organic Chemistry Enabled by Mechanochemical Activation. Synthesis 2023, 55, 2439–2459. doi:10.1055/a-2085-3410
• Auvray, T.; Friščić, T. Shaking Things from the Ground-Up: A Systematic Overview of the Mechanochemistry of Hard and High-Melting Inorganic Materials. Molecules (Basel, Switzerland) 2023, 28, 897. doi:10.3390/molecules28020897
• Julien, P. A.; Friščić, T. Methods for Monitoring Milling Reactions and Mechanistic Studies of Mechanochemistry: A Primer. Crystal Growth & Design 2022, 22, 5726–5754. doi:10.1021/acs.cgd.2c00587
• Zeitler, S. M.; Chakma, P.; Golder, M. R. Diaryliodonium salts facilitate metal-free mechanoredox free radical polymerizations. Chemical science 2022, 13, 4131–4138. doi:10.1039/d2sc00313a
• Bento, O.; Luttringer, F.; Mohy El Dine, T.; Pétry, N.; Bantreil, X.; Lamaty, F. Sustainable Mechanosynthesis of Biologically Active Molecules. European Journal of Organic Chemistry 2022, 2022. doi:10.1002/ejoc.202101516
• Gonnet, L.; Lennox, C. B.; Do, J.; Malvestiti, I.; Koenig, S. G.; Nagapudi, K.; Friščić, T. Metal‐Catalyzed Organic Reactions by Resonant Acoustic Mixing**. Angewandte Chemie 2022, 134. doi:10.1002/ange.202115030
• Gonnet, L.; Lennox, C.; Do, J.-L.; Malvestiti, I.; Koenig, S. G.; Nagapudi, K.; Friščić, T. Metal-catalyzed organic reactions by Resonant Acoustic Mixing. Angewandte Chemie (International ed. in English) 2022, 61, e202115030. doi:10.33774/chemrxiv-2021-gj7tq

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