Supporting Information
| Supporting Information File 1: Full details of peptide characterization, initial screening results, dose response curves for CSP1 analogs, and CD spectra of all the CSP1 analogs. | ||
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Cite the Following Article
Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae
Bimal Koirala, Robert A. Hillman, Erin K. Tiwold, Michael A. Bertucci and Yftah Tal-Gan
Beilstein J. Org. Chem. 2018, 14, 1769–1777.
https://doi.org/10.3762/bjoc.14.151
How to Cite
Koirala, B.; Hillman, R. A.; Tiwold, E. K.; Bertucci, M. A.; Tal-Gan, Y. Beilstein J. Org. Chem. 2018, 14, 1769–1777. doi:10.3762/bjoc.14.151
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Scholarly Works
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- Milly, T. A.; Tal-Gan, Y. Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections. Peptide science (Hoboken, N.J.) 2022, 115. doi:10.1002/pep2.24298
- Milly, T. A.; Buttner, A. R.; Rieth, N.; Hutnick, E.; Engler, E. R.; Campanella, A. R.; Lella, M.; Bertucci, M. A.; Tal-Gan, Y. Optimizing CSP1 analogs for modulating quorum sensing in Streptococcus pneumoniae with bulky, hydrophobic nonproteogenic amino acid substitutions. RSC chemical biology 2022, 3, 301–311. doi:10.1039/d1cb00224d
- Milly, T. A.; Engler, E. R.; Chichura, K. S.; Buttner, A. R.; Koirala, B.; Tal-Gan, Y.; Bertucci, M. A. Harnessing Multiple, Nonproteogenic Substitutions to Optimize CSP:ComD Hydrophobic Interactions in Group 1 Streptococcus pneumoniae. Chembiochem : a European journal of chemical biology 2021, 22, 1940–1947. doi:10.1002/cbic.202000876
- Lella, M.; Tal-Gan, Y. Strategies to Attenuate the Competence Regulon in Streptococcus pneumoniae. Peptide science (Hoboken, N.J.) 2021, 113. doi:10.1002/pep2.24222
- McBrayer, D. N.; Cameron, C. D.; Tal-Gan, Y. Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria. Organic & biomolecular chemistry 2020, 18, 7273–7290. doi:10.1039/d0ob01421d
- Milly, T. A.; Tal-Gan, Y. Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveal Potential Crosstalk Between Streptococcus mitis and Streptococcus pneumoniae and a New Scaffold for the Development of S. pneumoniae Quorum Sensing Modulators. RSC chemical biology 2020, 1, 60–67. doi:10.1039/d0cb00012d
- Koirala, B.; Tal-Gan, Y. Development of Streptococcus pneumoniae Pan-Group Quorum-Sensing Modulators. Chembiochem : a European journal of chemical biology 2019, 21, 340–345. doi:10.1002/cbic.201900365
- Koirala, B.; Phillips, N. R.; Tal-Gan, Y. Unveiling the Importance of Amide Protons in CSP:ComD Interactions in Streptococcus pneumoniae. ACS medicinal chemistry letters 2019, 10, 880–886. doi:10.1021/acsmedchemlett.9b00038
- Koirala, B.; Lin, J.; Lau, G. W.; Tal-Gan, Y. Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia. Chembiochem : a European journal of chemical biology 2018, 19, 2380–2386. doi:10.1002/cbic.201800505
- Yang, Y.; Cornilescu, G.; Tal-Gan, Y. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry 2018, 57, 5359–5369. doi:10.1021/acs.biochem.8b00653
