Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

Imane Nekkaa, Márta Palkó, István M. Mándity and Ferenc Fülöp
Beilstein J. Org. Chem. 2018, 14, 318–324. https://doi.org/10.3762/bjoc.14.20

Supporting Information

Supporting Information File 1: Experimental procedures and analytical data.
Format: PDF Size: 1.1 MB Download

Cite the Following Article

Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives
Imane Nekkaa, Márta Palkó, István M. Mándity and Ferenc Fülöp
Beilstein J. Org. Chem. 2018, 14, 318–324. https://doi.org/10.3762/bjoc.14.20

How to Cite

Nekkaa, I.; Palkó, M.; Mándity, I. M.; Fülöp, F. Beilstein J. Org. Chem. 2018, 14, 318–324. doi:10.3762/bjoc.14.20

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 311.9 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Orrego-Hernández, J.; Hölzel, H.; Quant, M.; Wang, Z.; Moth-Poulsen, K. Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry. European Journal of Organic Chemistry 2021, 2021, 5337–5342. doi:10.1002/ejoc.202100795
  • Gambacorta, G.; Sharley, J. S.; Baxendale, I. R. A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries. Beilstein journal of organic chemistry 2021, 17, 1181–1312. doi:10.3762/bjoc.17.90
  • Alfano, A. I.; Brindisi, M.; Lange, H. Flow synthesis approaches to privileged scaffolds – recent routes reviewed for green and sustainable aspects. Green Chemistry 2021, 23, 2233–2292. doi:10.1039/d0gc03883k
  • Haimer, M. E.; Palkó, M.; Haukka, M.; Gajdács, M.; Zupkó, I.; Fülöp, F. Synthesis and biological evaluation of the new ring system benzo[ f ]pyrimido[1,2- d ][1,2,3]triazolo[1,5- a ][1,4]diazepine and its cycloalkane and cycloalkene condensed analogues. RSC advances 2021, 11, 6952–6957. doi:10.1039/d0ra10553h
  • Said, A. I.; Palkó, M.; Haukka, M.; Fülöp, F. Retro Diels Alder protocol for regioselective synthesis of novel [1,2,4]triazolo[4,3-a]pyrimidin-7(1H)-ones. RSC advances 2020, 10, 33937–33943. doi:10.1039/d0ra04345a
  • Bloemendal, V. R. L. J.; Janssen, M. A. C. H.; van Hest, J. C. M.; Rutjes, F. P. J. T. Continuous one-flow multi-step synthesis of active pharmaceutical ingredients. Reaction Chemistry & Engineering 2020, 5, 1186–1197. doi:10.1039/d0re00087f
  • Bai-cheng, F.; Xi-chao, H.; Tie-lin, W.; Jian-qiang, L.; Yan, J. Synthesis of Bicyclic Esters in a Continuous-Flow Microreactor. ChemistrySelect 2020, 5, 952–956. doi:10.1002/slct.201903919
  • Liu, C.; Witt, L.; Ianes, C.; Bischof, J.; Bammert, M.-T.; Baier, J.; Kirschner, S.; Henne-Bruns, D.; Xu, P.; Kornmann, M.; Peifer, C.; Knippschild, U. Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. International journal of molecular sciences 2019, 20, 6184. doi:10.3390/ijms20246184
  • Nekkaa, I.; Bogdán, D.; Gáti, T.; Béni, S.; Juhász, T.; Palkó, M.; Paragi, G.; Tóth, G.; Fülöp, F.; Mándity, I. M. Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation. Chemical communications (Cambridge, England) 2019, 55, 3061–3064. doi:10.1039/c8cc10147g
  • Galaverna, R.; Fernandes, L. P.; Browne, D. L.; Pastre, J. C. Continuous flow processing as a tool for the generation of terpene-derived monomer libraries. Reaction Chemistry & Engineering 2019, 4, 362–367. doi:10.1039/c8re00237a
  • Nekkaa, I.; Palkó, M.; Mándity, I. M.; Miklós, F.; Fülöp, F. Continuous-Flow retro-Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds. European Journal of Organic Chemistry 2018, 2018, 4456–4464. doi:10.1002/ejoc.201800682
  • Abu-Laban, M.; Kumal, R. R.; Casey, J. S.; Becca, J.; LaMaster, D. J.; Pacheco, C.; Sykes, D.; Jensen, L.; Haber, L. H.; Hayes, D. J. Comparison of thermally actuated retro-diels-alder release groups for nanoparticle based nucleic acid delivery. Journal of colloid and interface science 2018, 526, 312–321. doi:10.1016/j.jcis.2018.04.085
Other Beilstein-Institut Open Science Activities