Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

Scholarly Works

• Milli, G.; Pellegrini, A.; Listro, R.; Fasolini, M.; Pagano, K.; Ragona, L.; Pietrocola, G.; Linciano, P.; Collina, S. New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation. Journal of medicinal chemistry 2024, 67, 18139–18156. doi:10.1021/acs.jmedchem.4c01266
• Boakye, A.; Seidu, M. P.; Adomako, A.; Laryea, M. K.; Borquaye, L. S. Marine-Derived Furanones Targeting Quorum-Sensing Receptors in Pseudomonas aeruginosa: Molecular Insights and Potential Mechanisms of Inhibition. Bioinformatics and biology insights 2024, 18, 11779322241275843. doi:10.1177/11779322241275843
• Rodríguez-Urretavizcaya, B.; Vilaplana, L.; Marco, M.-P. Strategies for quorum sensing inhibition as a tool for controlling Pseudomonas aeruginosa infections. International journal of antimicrobial agents 2024, 64, 107323. doi:10.1016/j.ijantimicag.2024.107323
• Angelov, P.; Mollova-Sapundzhieva, Y.; Nedialkov, P. Attempted Synthesis of the Pseudomonas aeruginosa Metabolite 2-Benzyl-4(1H)-quinolone and Formation of 3-Methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an Unexpected Product. Molbank 2024, 2024, M1877. doi:10.3390/m1877
• Abdelsamie, A. S.; Hamed, M. M.; Schütz, C.; Röhrig, T.; Kany, A. M.; Schmelz, S.; Blankenfeldt, W.; Hirsch, A. K. H.; Hartmann, R. W.; Empting, M. Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity. European journal of medicinal chemistry 2024, 276, 116685. doi:10.1016/j.ejmech.2024.116685
• Teja, P. K.; Ranjan, S.; Takamizawa, S. Twinning Organosuperelasticity in a 4-Nitroanthranilic Acid Solvate Crystal. Crystal Growth & Design 2024, 24, 4306–4311. doi:10.1021/acs.cgd.3c01168
• Ammazzalorso, A.; Granese, A.; De Filippis, B. Recent trends and challenges to overcome Pseudomonas aeruginosa infections. Expert opinion on therapeutic patents 2024, 34, 493–509. doi:10.1080/13543776.2024.2348602
• Nagashri, N.; Archana, L.; Raghavan, R. Microbial Volatile Compounds (MVOCs) in Food Industries and Food Safety Applications. Innovations, Securities, and Case Studies Across Healthcare, Business, and Technology; IGI Global, 2024; pp 75–96. doi:10.4018/979-8-3693-1906-2.ch005
• Vieira, T. F.; Leitão, M. M.; Cerqueira, N. M. F. S. A.; Sousa, S. F.; Borges, A.; Simões, M. Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents against Pseudomonas aeruginosa. Journal of applied microbiology 2024, 135. doi:10.1093/jambio/lxae088
• Elfadadny, A.; Ragab, R. F.; AlHarbi, M.; Badshah, F.; Ibáñez-Arancibia, E.; Farag, A.; Hendawy, A. O.; De Los Ríos-Escalante, P. R.; Aboubakr, M.; Zakai, S. A.; Nageeb, W. M. Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Frontiers in microbiology 2024, 15, 1374466. doi:10.3389/fmicb.2024.1374466
• Deery, J.; Carmody, M.; Flavin, R.; Tomanek, M.; O'Keeffe, M.; McGlacken, G. P.; Reen, F. J. Comparative genomics reveals distinct diversification patterns among LysR-type transcriptional regulators in the ESKAPE pathogen Pseudomonas aeruginosa. Microbial genomics 2024, 10. doi:10.1099/mgen.0.001205
• Adouane, E.; Mercier, C.; Mamelle, J.; Willocquet, E.; Intertaglia, L.; Burgunter-Delamare, B.; Leblanc, C.; Rousvoal, S.; Lami, R.; Prado, S. Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome. iScience 2024, 27, 109176. doi:10.1016/j.isci.2024.109176
• Weigert Muñoz, A.; Zhao, W.; Sieber, S. A. Monitoring host-pathogen interactions using chemical proteomics. RSC chemical biology 2024, 5, 73–89. doi:10.1039/d3cb00135k
• Abdelsamie, A. S.; Hamed, M. M.; Schütz, C.; Röhrig, T.; Kany, A. M.; Schmelz, S.; Blankenfeldt, W.; Hirsch, A. K. H.; Hartmann, R. W.; Empting, M. Discovery and Optimization of Thiazole-Based Quorum Sensing Inhibitors as Potent Blockers of Pseudomonas Aeruginosa Pathogenicity. Elsevier BV 2024. doi:10.2139/ssrn.4789988
• Mollova-Sapundzhieva, Y.; Angelov, P.; Georgiev, D.; Yanev, P. Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors. Beilstein journal of organic chemistry 2023, 19, 1804–1810. doi:10.3762/bjoc.19.132
• Miao, Z.-Y.; Zhang, X.-Y.; Yang, M.-H.; Huang, Y.-J.; Lin, J.; Chen, W.-M. 3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa. Journal of medicinal chemistry 2023, 66, 15823–15846. doi:10.1021/acs.jmedchem.3c01328
• Guo, Y.; Mao, Z.; Ran, F.; Sun, J.; Zhang, J.; Chai, G.; Wang, J. Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections. Pharmaceutics 2023, 15, 2582. doi:10.3390/pharmaceutics15112582
• Zhang, H.; Zhang, Z.; Li, J.; Qin, G. New Strategies for Biocontrol of Bacterial Toxins and Virulence: Focusing on Quorum-Sensing Interference and Biofilm Inhibition. Toxins 2023, 15, 570. doi:10.3390/toxins15090570
• Samotrueva, M. A.; Starikova, A. A.; Bashkina, O. A.; Tsibizova, A. A.; Borisov, A. V.; Merezhkina, D. V.; Tyurenkov, I. N.; Ozerov, A. A. Biochemical Basis of the Antimicrobial Activity of Quinazolinone Derivatives in the Light of Insights into the Features of the Chemical Structure and Ways of Binding to Target Molecules. A Review. Doklady Chemistry 2023, 510, 107–129. doi:10.1134/s0012500823600463
• Perković, I.; Poljak, T.; Savijoki, K.; Varmanen, P.; Maravić-Vlahoviček, G.; Beus, M.; Kučević, A.; Džajić, I.; Rajić, Z. Synthesis and Biological Evaluation of New Quinoline and Anthranilic Acid Derivatives as Potential Quorum Sensing Inhibitors. Molecules (Basel, Switzerland) 2023, 28, 5866. doi:10.3390/molecules28155866

Explore citations to this article at