Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids

Herman O. Sintim, Hamad H. Al Mamari, Hasanain A. A. Almohseni, Younes Fegheh-Hassanpour and David M. Hodgson
Beilstein J. Org. Chem. 2019, 15, 1194–1202. https://doi.org/10.3762/bjoc.15.116

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Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids
Herman O. Sintim, Hamad H. Al Mamari, Hasanain A. A. Almohseni, Younes Fegheh-Hassanpour and David M. Hodgson
Beilstein J. Org. Chem. 2019, 15, 1194–1202. https://doi.org/10.3762/bjoc.15.116

How to Cite

Sintim, H. O.; Al Mamari, H. H.; Almohseni, H. A. A.; Fegheh-Hassanpour, Y.; Hodgson, D. M. Beilstein J. Org. Chem. 2019, 15, 1194–1202. doi:10.3762/bjoc.15.116

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  • Almohseni, H. A. A.; Hodgson, D. M. Evolution of a Cycloaddition–Rearrangement Approach to the Squalestatins: A Quarter-Century Odyssey. Synlett 2020, 31, 1555–1572. doi:10.1055/s-0040-1707127
  • Sintim, H. O.; Valade, A.; Harling, D. C.; Hodgson, D. M. Squarate desymmetrisation–ozonolysis as an approach to β-substituted-α-ketosuccinates and squalestatin synthesis. Tetrahedron 2019, 75, 130747. doi:10.1016/j.tet.2019.130747
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