Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering

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• Zhang, X.; Chen, H.; Wang, Y.; Xie, S.; Wang, Z.; Qian, J.; Lin, X.; Li, F.-R.; Pan, X.; Xu, H.-M.; Liang, Y.; Dong, L.-B. Exploring bacterial cytochrome P450s for selective activation of aliphatic C-H bonds in pentacyclic triterpenoids. Nature chemistry 2026. doi:10.1038/s41557-026-02106-9
• Herrera-Cardoso, E. D.; Tapia-Cervantes, K. A.; Cepeda-Negrete, J.; Gutiérrez-Vargas, S.; León-Galván, M. F. Genome sequencing analysis reveals probiotic potential of Lactiplantibacillus plantarum IGMA4EH isolated from the gut of the white maguey worm (Aegiale hesperiaris). BMC genomics 2026. doi:10.1186/s12864-026-12798-5
• Mizuno, H.; Tokuhiro, K.; Iwai, K.; Furuta, Y.; Nakasone, A.; Tanaka, H.; Sugimoto, H. Transcriptional and functional characterization of terpene synthase genes of the aromatic plant Plectranthus hadiensis. PloS one 2026, 21, e0345772. doi:10.1371/journal.pone.0345772
• Yogeswara, I. B. A.; Nursini, N. W.; Kusumawati, I. G. A. W.; Fidriyanto, R.; Haltrich, D. Enhanced Postbiotic Metabolite GABA Production in Skim Milk Using Weissella cibaria UF-274 and Whole-Genome Analysis. Metabolites 2026, 16, 175. doi:10.3390/metabo16030175
• Blevins, A. M.; Peng, W.; Kinch, L. N.; Monshad, Z.; Paredes, A. G.; Volz, C.; Rutter, J.; Casey, A. K.; Hicks, K. G.; Orth, K. Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates. Proceedings of the National Academy of Sciences of the United States of America 2026, 123, e2533457123. doi:10.1073/pnas.2533457123
• Hyun, K.-A.; Kim, J.-H.; Ko, M. N.; Hyun, C.-G. Whole-Genome Sequencing and Genomic Features of Vagococcus sp. JNUCC 83 Isolated from Camellia japonica Flowers. Microbiology Research 2026, 17, 23. doi:10.3390/microbiolres17010023
• Han, H.; Gong, R.; Jin, Z.; Wang, L.; Zhang, B.; Song, B.; Ren, Z. Whole-genome analysis and fermentation-metabolite profiling of a cellulolytic Arthrobacter sp. FMD isolated from forest musk-deer faeces. BMC microbiology 2026, 26, 43. doi:10.1186/s12866-025-04441-2
• Rahman, M. S.; Islam, M. T.; Hasan, M.; Tariquzzaman, M.; Samia, N. S. N.; Rahman, M. M.; Rahman, M. Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain. PloS one 2025, 20, e0333844. doi:10.1371/journal.pone.0333844
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• Cuaxinque-Flores, G.; Gómez-Godínez, L. J.; Armenta-Medina, A.; Zelaya-Molina, L. X.; Ramos-Garza, J.; Aguirre-Noyola, J. L. Genome Insights into Kocuria sp. KH4, a Metallophilic Bacterium Harboring Multiple Biosynthetic Gene Clusters (BGCs). Microbiology Research 2025, 16, 255. doi:10.3390/microbiolres16120255
• Muhammad, N.; Jeon, J.; Kim, E.; Kim, D.; Lee, Y. M. Rhodococcus aromaticivorans sp. nov., an o-xylene degrading bacterium, and evidence supporting reclassification of Rhodococcus jostii RHA1. PloS one 2025, 20, e0337194. doi:10.1371/journal.pone.0337194
• Swaroop, A. Bioactive Drugs from Mushrooms and Fungi. Natural Product Drugs; Royal Society of Chemistry, 2025; pp 101–147. doi:10.1039/9781837676989-00101
• Liao, S.; Mo, H.; Gao, Y.; Bouphun, T.; Xu, W.; Lin, L. Study on the influence of microorganisms on the flavor of black tea. Food chemistry: X 2025, 31, 103173. doi:10.1016/j.fochx.2025.103173
• Xia, Q.; Zhang, D.; Li, Z.; Yang, C.; Liu, P.; Wang, H.; Jin, Y.; Li, M.; Dong, J.; Guan, X.; Tong, L.; Fan, Y.; Gu, T.; Wang, F.; Xu, D. Bioleaching of valuable metals from spent lithium iron phosphate batteries using food-grade Lactobacillus acidophilus. Chemical Engineering Journal 2025, 521, 166799. doi:10.1016/j.cej.2025.166799
• Bekele, G. K.; Balcha, E. S.; Meka, A. F.; Assefa, E. G.; Abda, E. M.; Tuji, F. A.; Gemeda, M. T. Unveiling microbial secondary metabolite biosynthetic gene clusters from alkaline soda Lake Chitu, in the Ethiopian Rift Valley. Electronic Journal of Biotechnology 2025, 77, 48–58. doi:10.1016/j.ejbt.2025.06.002
• Han¹, H.; Gong¹, R.; Jin¹, Z.; Wang¹, L.; Zhang², B.; Song¹, B.; Ren¹, Z. Whole-genome analysis and fermentation-metabolite profiling of a cellulolytic Arthrobacter sp. FMD isolated from forest musk-deer faeces. Springer Science and Business Media LLC 2025. doi:10.21203/rs.3.rs-7059040/v1
• Salim, S.; Sugathan, S. Characterisation of Exiguobacterium abrahamii sp. nov., a novel strain isolated from mangrove soil with lanthipeptide biosynthetic genes. Antonie van Leeuwenhoek 2025, 118, 76. doi:10.1007/s10482-025-02079-8
• Hao, Y.; Liu, M.; Fordjour, E.; Yu, P.; Yang, Y.; Liu, X.; Li, Y.; Liu, C.-L.; Bai, Z. Engineering Escherichia coli for Perillyl Alcohol Production with Reduced Endogenous Dehydrogenation. ACS synthetic biology 2025, 14, 1594–1605. doi:10.1021/acssynbio.4c00854
• Hanssens, J.; Meneses, D.; Saya, J. M.; Orru, R. V. A. Terpenes and Terpenoids: How can we use them?. European Journal of Organic Chemistry 2025, 28. doi:10.1002/ejoc.202401151

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