Anthelmintic drug discovery: target identification, screening methods and the role of open science

Scholarly Works

• Mia, M. M.; Allaie, I. M.; Zhang, X.; Li, K.; Khan, S. M.; Kadotani, S.; Witola, W. H. Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes. PLoS neglected tropical diseases 2024, 18, e0012473. doi:10.1371/journal.pntd.0012473
• Araújo, J. V. d.; Fonseca, J. D. S.; Barbosa, B. B.; Valverde, H. A.; Santos, H. A.; Braga, F. R. The Role of Helminthophagous Fungi in the Biological Control of Human and Zoonotic Intestinal Helminths. Pathogens (Basel, Switzerland) 2024, 13, 741. doi:10.3390/pathogens13090741
• Taylor, L.; Ahmada, A. A.; Ali, M. S.; Ali, S. M.; Hattendorf, J.; Mohammed, I. S.; Keiser, J. Efficacy and safety of emodepside compared with albendazole in adolescents and adults with hookworm infection in Pemba Island, Tanzania: a double-blind, superiority, phase 2b, randomised controlled trial. Lancet (London, England) 2024, 404, 683–691. doi:10.1016/s0140-6736(24)01403-x
• Akramova, F.; Shakarbaev, U.; Paluaniyazova, D.; Akbarov, A.; Khalikov, S.; Safarov, A.; Azimov, D.; Ben Said, M. Assessing the effectiveness of fenbendazole supramolecular complexes against schistosomiasis, monieziosis and parabronemosis in sheep. Experimental parasitology 2024, 258, 108714. doi:10.1016/j.exppara.2024.108714
• Taylor, L.; Ahmada, A.; Ali, M. S.; Ali, S. M.; Hattendorf, J.; Said, I.; Keiser, J. Efficacy and Safety of Emodepside Compared to Albendazole in Adolescents and Adults Infected with Hookworm in Pemba Island, Tanzania: A Double-Blind, Superiority, Phase 2b, Randomised Controlled Trial. Elsevier BV 2024. doi:10.2139/ssrn.4828827
• Ng'etich, A. I.; Amoah, I. D.; Bux, F.; Kumari, S. Anthelmintic resistance in soil-transmitted helminths: One-Health considerations. Parasitology research 2023, 123, 62. doi:10.1007/s00436-023-08088-8
• Folliero, V.; Dell'Annunziata, F.; Santella, B.; Roscetto, E.; Zannella, C.; Capuano, N.; Perrella, A.; De Filippis, A.; Boccia, G.; Catania, M. R.; Galdiero, M.; Franci, G. Repurposing Selamectin as an Antimicrobial Drug against Hospital-Acquired Staphylococcus aureus Infections. Microorganisms 2023, 11, 2242. doi:10.3390/microorganisms11092242
• Coghlan, A.; Partridge, F. A.; Duque-Correa, M. A.; Rinaldi, G.; Clare, S.; Seymour, L.; Brandt, C.; Mkandawire, T. T.; McCarthy, C.; Holroyd, N.; Nick, M.; Brown, A. E.; Tonitiwong, S.; Sattelle, D. B.; Berriman, M. A drug repurposing screen for whipworms informed by comparative genomics. PLoS neglected tropical diseases 2023, 17, e0011205. doi:10.1371/journal.pntd.0011205
• Kołodziej, P.; Wujec, M.; Doligalska, M.; Makuch-Kocka, A.; Khylyuk, D.; Bogucki, J.; Demkowska-Kutrzepa, M.; Roczeń-Karczmarz, M.; Studzińska, M.; Tomczuk, K.; Kocki, M.; Reszka-Kocka, P.; Granica, S.; Typek, R.; Dawidowicz, A. L.; Kocki, J.; Bogucka-Kocka, A. Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study. Journal of advanced research 2023, 60, 57–73. doi:10.1016/j.jare.2023.07.004
• Hamid, L.; Alsayari, A.; Tak, H.; Mir, S. A.; Almoyad, M. A. A.; Wahab, S.; Bader, G. N. An Insight into the Global Problem of Gastrointestinal Helminth Infections amongst Livestock: Does Nanotechnology Provide an Alternative?. Agriculture 2023, 13, 1359. doi:10.3390/agriculture13071359
• Zhang, X.; Sicalo Gianechini, L.; Li, K.; Kaplan, R. M.; Witola, W. H. Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy. Antimicrobial agents and chemotherapy 2023, 67, e0000823. doi:10.1128/aac.00008-23
• Coghlan, A.; Partridge, F. A.; Duque-Correa, M. A.; Rinaldi, G.; Clare, S.; Seymour, L.; Brandt, C.; Mkandawire, T. T.; McCarthy, C.; Holroyd, N.; Nick, M.; Brown, A. E.; Tonitiwong, S.; Sattelle, D. B.; Berriman, M. A drug repurposing screen for whipworms informed by comparative genomics. Cold Spring Harbor Laboratory 2023. doi:10.1101/2023.03.02.530747
• Sharma, S.; Singh, D.; Kumar, S.; Vaishali; Jamra, R.; Banyal, N.; Deepika; Malakar, C. C.; Singh, V. An efficient metal-free and catalyst-free C-S/C-O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides. Beilstein journal of organic chemistry 2023, 19, 231–244. doi:10.3762/bjoc.19.22
• Bansal, K. K.; Goyal, R.; Sharma, A.; Sharma, P. C.; Goyal, R. K. Repurposing of Drugs for the Treatment of Microbial Diseases. Drug Repurposing for Emerging Infectious Diseases and Cancer; Springer Nature Singapore, 2023; pp 347–394. doi:10.1007/978-981-19-5399-6_16
• Burrows, J. N.; Cooper, C. B.; Mowbray, C.; Sjö, P. Medicinal Chemistry for Neglected Diseases – Malaria, Tuberculosis, Sleeping Sickness, Leishmaniasis and River Blindness. The Handbook of Medicinal Chemistry; The Royal Society of Chemistry, 2023; pp 873–910. doi:10.1039/9781788018982-00873
• de Korne, C. M.; van Lieshout, L.; van Leeuwen, F. W. B.; Roestenberg, M. Imaging as a (pre)clinical tool in parasitology. Trends in parasitology 2023, 39, 212–226. doi:10.1016/j.pt.2022.12.008
• Belen'kii, L. I.; Gazieva, G. A.; Evdokimenkova, Y. B.; Soboleva, N. O. The literature of heterocyclic chemistry, Part XX, 2020. Advances in Heterocyclic Chemistry; Elsevier, 2023; pp 201–274. doi:10.1016/bs.aihch.2022.10.005
• Deep, A.; Chikara, P.; Sharma, P.; Sharma, A.; Dhobi, M.; Chander Sharma, P. Vermifuge and vermicide drugs. Medicinal Chemistry of Chemotherapeutic Agents; Elsevier, 2023; pp 463–497. doi:10.1016/b978-0-323-90575-6.00011-9
• Nick, M.; Partridge, F. A.; Forman, R.; Bataille, C. J. R.; Else, K. J.; Russell, A. J.; Sattelle, D. B. Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads. Frontiers in Tropical Diseases 2022, 3. doi:10.3389/fitd.2022.1017900
• Nick, M.; Partridge, F. A.; Forman, R.; Bataille, C. J.; Else, K. J.; Russell, A. J.; Sattelle, D. B. Screening the Medicines for Malaria Pandemic Response Box chemical library onCaenorhabditis elegansidentifies re-profiled candidate anthelmintic drug leads. Cold Spring Harbor Laboratory 2022. doi:10.1101/2022.08.10.503491

Explore citations to this article at