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Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Alexander V. Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J. C. Struijs, Michelle Ho, Moisés Gulías, Ying Wang and Timothy Noël

Beilstein J. Org. Chem. 2020, 16, 1305–1312. https://doi.org/10.3762/bjoc.16.111

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Supporting Information File 1: Procedure for continuous-flow and batch trifluoromethoxylation reactions and ¹⁹F NMR spectra of compounds 2–37.
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Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Alexander V. Nyuchev, Ting Wan, Borja Cendón, Carlo Sambiagio, Job J. C. Struijs, Michelle Ho, Moisés Gulías, Ying Wang and Timothy Noël

Beilstein J. Org. Chem. 2020, 16, 1305–1312. https://doi.org/10.3762/bjoc.16.111

How to Cite

Nyuchev, A. V.; Wan, T.; Cendón, B.; Sambiagio, C.; Struijs, J. J. C.; Ho, M.; Gulías, M.; Wang, Y.; Noël, T. Beilstein J. Org. Chem. 2020, 16, 1305–1312. doi:10.3762/bjoc.16.111

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TY  - JOUR
A1  - Nyuchev, Alexander V.
A1  - Wan, Ting
A1  - Cendón, Borja
A1  - Sambiagio, Carlo
A1  - Struijs, Job J. C.
A1  - Ho, Michelle
A1  - Gulías, Moisés
A1  - Wang, Ying
A1  - Noël, Timothy
T1  - Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
JF  - Beilstein Journal of Organic Chemistry
PY  - 2020///
VL  - 16
SP  - 1305
EP  - 1312
SN  - 1860-5397
DO  - 10.3762/bjoc.16.111
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.16.111
KW  - C–H functionalization
KW  - continuous-flow
KW  - organic synthesis
KW  - photoredox catalysis
KW  - trifluoromethoxylation
N2  - The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.
ER  -

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)