Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo

Scholarly Works

• Fink, M.; Wolfrum, S.; Lang, R.; Thiel, V.; Carreira, E. M. Photoswitchable RNA Degraders for Spatiotemporal Activation of Host-Directed Antivirals in Mammalian Cells. Journal of the American Chemical Society 2025. doi:10.1021/jacs.5c13457
• Lazinski, L. M.; Beaumet, M.; Loiseau, F.; Goudet, C.; Boggio‐Pasqua, M.; Royal, G.; Haudecoeur, R. Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light. ChemistryEurope 2025, 3. doi:10.1002/ceur.202500221
• Bakhtiiari, A.; Liang, R. Unraveling Solvent and Substituent Effects in the Photodynamics of Light-Dependent Microtubule Inhibitors for Cancer Phototherapy. Journal of computational chemistry 2025, 46, e70076. doi:10.1002/jcc.70076
• Xu, Y.; Tang, Y.; Li, Q. Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications. Advanced Functional Materials 2024, 35. doi:10.1002/adfm.202416359
• Schmitt, C.; Mauker, P.; Vepřek, N. A.; Gierse, C.; Meiring, J. C. M.; Kuch, J.; Akhmanova, A.; Dehmelt, L.; Thorn‐Seshold, O. A Photocaged Microtubule‐Stabilising Epothilone Allows Spatiotemporal Control of Cytoskeletal Dynamics. Angewandte Chemie 2024, 136. doi:10.1002/ange.202410169
• Schmitt, C.; Mauker, P.; Vepřek, N. A.; Gierse, C.; Meiring, J. C. M.; Kuch, J.; Akhmanova, A.; Dehmelt, L.; Thorn-Seshold, O. A Photocaged Microtubule-Stabilising Epothilone Allows Spatiotemporal Control of Cytoskeletal Dynamics. Angewandte Chemie (International ed. in English) 2024, 63, e202410169. doi:10.1002/anie.202410169
• Josa-Culleré, L.; Aira Rodríguez, C.; Llebaria, A. Hemithioindigo-based histone deacetylase inhibitors induce a light-dependent anticancer effect. European journal of medicinal chemistry 2024, 279, 116846. doi:10.1016/j.ejmech.2024.116846
• La Monica, G.; Alamia, F.; Bono, A.; Lauria, A.; Martorana, A. Scaffold-Hopping Strategies in Aurone Optimization: A Comprehensive Review of Synthetic Procedures and Biological Activities of Nitrogen and Sulfur Analogues. Molecules (Basel, Switzerland) 2024, 29, 2813. doi:10.3390/molecules29122813
• Seliwjorstow, A.; Takamiya, M.; Rastegar, S.; Pianowski, Z. Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo. Chembiochem : a European journal of chemical biology 2024, 25, e202400143. doi:10.1002/cbic.202400143
• Borys, F.; Tobiasz, P.; Fabczak, H.; Joachimiak, E.; Krawczyk, H. First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent. Cells 2023, 12, 1866. doi:10.3390/cells12141866
• Kobauri, P.; Dekker, F. J.; Szymanski, W.; Feringa, B. L. Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie (International ed. in English) 2023, 62, e202300681. doi:10.1002/anie.202300681
• Kobauri, P.; Dekker, F. J.; Szymanski, W.; Feringa, B. L. Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie 2023, 135. doi:10.1002/ange.202300681
• Nakamura, A.; Rao, F.; Ukiya, K.; Matsunaga, R.; Ohira, S.-I.; Maegawa, T. A concise synthesis of thioaurones via NBS-induced cyclization of MOM-protected 2'-mercaptochalcones. Organic & biomolecular chemistry 2023, 21, 1134–1137. doi:10.1039/d2ob01995g
• Kirchner, S.; Leistner, A.-L.; Gödtel, P.; Seliwjorstow, A.; Weber, S.; Karcher, J.; Nieger, M.; Pianowski, Z. Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity. Nature communications 2022, 13, 6066. doi:10.1038/s41467-022-33750-7
• Gao, L.; Kraus, Y.; Stegner, A.; Wein, T.; Heise, C.; von Brunn, L.; Fajardo-Ruiz, E.; Thorn-Seshold, J.; Thorn-Seshold, O. Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity. Organic & biomolecular chemistry 2022, 20, 7787–7794. doi:10.1039/d2ob00347c
• Lazinski, L. M.; Royal, G.; Robin, M.; Maresca, M.; Haudecoeur, R. Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives. Journal of medicinal chemistry 2022, 65, 12594–12625. doi:10.1021/acs.jmedchem.2c01150
• Borys, F.; Tobiasz, P.; Sobel, J.; Krawczyk, H. Synthesis and Study of Dibenzo[b, f]oxepine Combined with Fluoroazobenzenes-New Photoswitches for Application in Biological Systems. Molecules (Basel, Switzerland) 2022, 27, 5836. doi:10.3390/molecules27185836
• Ewert, J.; Heintze, L.; Jordà-Redondo, M.; von Glasenapp, J.-S.; Nonell, S.; Bucher, G.; Peifer, C.; Herges, R. Photoswitchable Diazocine-Based Estrogen Receptor Agonists: Stabilization of the Active Form inside the Receptor. Journal of the American Chemical Society 2022, 144, 15059–15071. doi:10.1021/jacs.2c03649
• Thorn‐Seshold, O. doi:10.1002/9783527827626.ch36
• Kirchner, S.; Pianowski, Z. Photopharmacology of Antimitotic Agents. International journal of molecular sciences 2022, 23, 5657. doi:10.3390/ijms23105657

Explore citations to this article at