Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis

Scholarly Works

• Singh, A.; Sindhe, H.; Kamble, A.; Rajkumar, K.; Agrawal, V.; Sharma, S. Recent advances in late-stage monofluorination of natural products and their derivatives. Organic Chemistry Frontiers 2024, 11, 5605–5637. doi:10.1039/d4qo01111b
• Kim, S.; Kim, H. Cu-Electrocatalysis Enables Vicinal Bis(difluoromethylation) of Alkenes: Unraveling Dichotomous Role of Zn(CF2H)2(DMPU)2 as Both Radical and Anion Source. Journal of the American Chemical Society 2024, 146, 22498–22508. doi:10.1021/jacs.4c06207
• Zeng, T.; Huang, C.; Zhang, Y.; Luo, Y.; Niu, D. C–H fluorination promoted by pyridine N-oxyl radicals. Green Chemistry 2024, 26, 8701–8705. doi:10.1039/d4gc02247e
• Atkins, A. P.; Dean, A. C.; Lennox, A. J. J. Benzylic C(sp3)-H fluorination. Beilstein journal of organic chemistry 2024, 20, 1527–1547. doi:10.3762/bjoc.20.137
• Ge, R.; Xu, Z.; Yang, K.; Ge, H. Transition-metal-catalyzed C(sp3)–H bond fluorination reactions. Chem Catalysis 2024, 4, 101009. doi:10.1016/j.checat.2024.101009
• Li, F.; Song, J.-W.; Zhang, C.-P.; Han, X. Progress in Photocatalyzed Trifluoromethylthiolation and Trifluoromethylselenolation Reactions. Synthesis 2024. doi:10.1055/a-2335-8627
• Li, W.; Li, Z.; Zhong, D.; Wang, N.; Li, H. Photoinduced Perfluoroalkyloximation of Alkenes with Simple Perfluoroalkyl Halides. Chinese Journal of Chemistry 2024, 42, 2217–2222. doi:10.1002/cjoc.202400181
• Das, A.; Justin Thomas, K. R. Generation and Application of Aryl Radicals Under Photoinduced Conditions. Chemistry (Weinheim an der Bergstrasse, Germany) 2024, 30, e202400193. doi:10.1002/chem.202400193
• Lu, X.; Wang, X.; Chen, S.; Fan, T.; Zhao, L.; Zhong, R.; Sun, G. The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods. Archives of toxicology 2024, 98, 2213–2229. doi:10.1007/s00204-024-03739-w
• Parsons, A. F.; Parsons, T. F. doi:10.1002/9781119716846.ch13
• Zhu, W. F.; Empel, C.; Pelliccia, S.; Koenigs, R. M.; Proschak, E.; Hernandez-Olmos, V. Photochemistry in Medicinal Chemistry and Chemical Biology. Journal of medicinal chemistry 2024, 67, 4322–4345. doi:10.1021/acs.jmedchem.3c02109
• Das, A.; Gouthaman, S.; Justin Thomas, K. R. Photocatalysis as a green alternative toolkit for the construction of nitrogen-enriched heterocycles via the direct and indirect activation of alkynes/alkenes. Green Chemistry 2024, 26, 1223–1280. doi:10.1039/d3gc03971d
• Atkins, A. P.; Chaturvedi, A. K.; Tate, J. A.; Lennox, A. J. J. Pulsed electrolysis: enhancing primary benzylic C(sp3)-H nucleophilic fluorination. Organic chemistry frontiers : an international journal of organic chemistry 2024, 11, 802–808. doi:10.1039/d3qo01865b
• Tian, X.; Liu, Y.; Yakubov, S.; Schütte, J.; Chiba, S.; Barham, J. P. Photo- and electro-chemical strategies for the activations of strong chemical bonds. Chemical Society reviews 2024, 53, 263–316. doi:10.1039/d2cs00581f
• Chen, Z.; Zhu, W.; Wang, C.; Xu, N.; Jin, Q.; Huang, X.; Song, S.; Li, J. Photoinduced regioselective difluorination of secondary inert C(sp3)–H bonds in sulfonamides via 1,5-hydrogen-atom transfer. Organic Chemistry Frontiers 2023, 10, 4709–4717. doi:10.1039/d3qo00931a
• Thomas, R. P.; Grant, E. K.; Dickinson, E. R.; Zappacosta, F.; Edwards, L. J.; Hann, M. M.; House, D.; Tomkinson, N. C. O.; Bush, J. T. Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry. RSC medicinal chemistry 2023, 14, 671–679. doi:10.1039/d2md00453d
• Dolna, M.; Narodowiec, J.; Staszewska-Krajewska, O.; Szcześniak, P.; Furman, B. Remotely controlled flow photo-Fries-type rearrangement of N-vinylazetidinones: an efficient route to structurally diverse 2,3-dihydro-4-pyridones. Reaction Chemistry & Engineering 2023, 8, 784–789. doi:10.1039/d2re00438k
• Castiello, C.; Junghanns, P.; Mergel, A.; Jacob, C.; Ducho, C.; Valente, S.; Rotili, D.; Fioravanti, R.; Zwergel, C.; Mai, A. GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design. Green Chemistry 2023, 25, 2109–2169. doi:10.1039/d2gc03772f
• Das, A.; Justin Thomas, K. R. Deconstruction of electron-deficient alkenes to carbonyl constituents by light-induced hydrogen atom transfer. Green Chemistry 2023, 25, 1078–1084. doi:10.1039/d2gc04424b
• Yamashita, K.; Fujiwara, Y.; Hamashima, Y. Amide-Ligand-Promoted Silver-Catalyzed C-H Fluorination via Radical/Polar Crossover. The Journal of organic chemistry 2023, 88, 1865–1874. doi:10.1021/acs.joc.2c02575

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