Logo Beilstein Institut

Hierarchically assembled helicates as reaction platform – from stoichiometric Diels–Alder reactions to enamine catalysis

  1. ORCID Logo ,
  2. ,
  3. ORCID Logo ,
  4. ,
  5. ,
  6. and
  7. ORCID Logo
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
  1. Corresponding author email
This article is part of the thematic issue "Molecular recognition" and is dedicated to the memory of Carsten Schmuck.
Guest Editor: J. Niemeyer
Beilstein J. Org. Chem. 2020, 16, 2338–2345. https://doi.org/10.3762/bjoc.16.195
Received 17 Jul 2020, Accepted 10 Sep 2020, Published 24 Sep 2020
A non-peer-reviewed version of this article has been posted as a preprint https://doi.org/10.3762/bxiv.2020.82.v1
Full Research Paper
cc by logo
PDF
Album
Supp Info
Cite

Abstract

The stereoselectivity of a Diels–Alder reaction within the periphery of hierarchically assembled titanium(IV) helicates formed from mixtures of achiral, reactive and chiral, unreactive ligands was investigated in detail. Following the pathway of the chiral induction, the chiral ligands, solvents as well as substituents at the dienophile were carefully varied. Based on the results of the stoichiometric reaction, a secondary amine-catalyzed nitro-Michael reaction is performed as well which afforded reasonable diastereoselectivities.

Keywords: Diels–Alder reaction; enamine catalysis; hierarchical helicates; remote-control; stereoselectivity

Introduction

Carbon–carbon (C–C) bond-forming reactions play a key role in organic chemistry. Hereby the stereoselectivity of the reaction is highly important due to the different behavior of stereoisomers in human metabolism [1,2]. Stereocontrol was achieved either via an auxiliary [3-7] or a catalyst [8], both providing the stereoinformation necessary for induction during the C–C bond formation. Catalytic approaches for C–C bond-forming reactions even found their way into the relatively young field of supramolecular chemistry, e.g., regioselective Diels–Alder reactions within supramolecular hosts as described by Fujita et al. [9-11] or stereoselective nucleophilic substitutions by Raymond et al. [12] are important examples in this context. Recently, we described the use of hierarchically assembled helicates as templates for stereoselective Diels–Alder reactions via a post-functionalization process [13]. Catechol ligands L-H2 with an ester functionality in the 3-position were prepared via conversion of the acid chloride of 2,3-dihydroxybenzoic acid to the corresponding esters. These ligands underwent a complexation with titanoyl(IV) bisacetylacetonate and lithium carbonate initially forming a mononuclear “Werner-type” triscatecholate titanium(IV) complex. Two of these monomers dimerized in a consecutive step to obtain a non-covalently linked helicate (Scheme 1). The dimerization took place via the coordination of three lithium cations acting as bridges between two monomeric complex units [13-20].

[1860-5397-16-195-i1]

Scheme 1: Formation of hierarchically assembled lithium-bridged titanium(IV) helicates as well as the ligands used for the stereoselective Diels–Alder reaction.

Enantioselectivities up to 25% ee at elevated temperature (32% ee at 0 °C) depending on the substrate were achieved in a Diels–Alder reaction by introducing two different substituted catechol ester ligands during the complex formation: (1) A diene-substituted ligand 1-H2 for the Diels–Alder reaction [21,22] and (2) a chiral ligand 2-H2 for the stereocontrol [13]. Cleaving the complex under acidic conditions resulted in the desired enantiomerically enriched product 9 and enabled the recovery of the chiral ligand 2-H2 (Scheme 2) [13].

[1860-5397-16-195-i2]

Scheme 2: Previously reported on/off switch for “remote-controlled” [23-31] stereoselectivity of a Diels–Alder reaction by use of different solvents. The heteroleptic complexes are mixtures with an average ligand distribution as shown [13].

The solvent choice allowed on/off-switching of the stereoselectivity of the Diels–Alder reaction. In THF the stereochemically locked dimer of the hierarchical helicate was present. Here stereoselectivity was turned on. On the other hand, the highly dynamic and fast diastereomerizing/epimerizing monomer was the major species in DMF switching off the stereoselectivity [13].

Herein we investigated the induction pathway and significantly optimized the stereoselectivity of the reaction. Furthermore, a catalytic approach was introduced which paves the way to the final goal of supramolecular stereoselective catalysis with hierarchical helicates as homogeneous catalysts.

Results and Discussion

Stereoselective Diels–Alder reactions in the periphery of hierarchically assembled helicates

Elucidating the induction pathway of the Diels–Alder reaction is vital for the optimization of the system described above and for the development of future processes based on the principle to use self-assembled coordination platforms (or as in the present case mixtures thereof) to control stereoselective C–C bond-forming reactions. Stereoinduction usually relies on spatial proximity of the prochiral carbon atoms and a chiral information of, e.g., a chiral auxiliary, Lewis acid or catalyst. In the previously reported system two different induction pathways were conceivable: (1) A chiral ligand is located close to the diene and controls the stereochemistry of the cycloaddition. (2) The chiral ligand controls the helicity of the helicate (ΔΔ or ΛΛ) and the helix induces the stereoselectivity of the Diels–Alder reaction.

To find out which of the induction pathways takes over the control of the Diels–Alder reaction in the periphery of the helicates, a specific helicity was induced at an achiral diene bearing helicate. It has been described before that an addition of chiral ammonium salts leads to the preference of a specific twist at the helicate [32]. As inductor, (R)-1-phenylethylammonium chloride was added to the racemic hexadiene-substituted helicate [Li3(1)6Ti2]−. The chiral salt influences the helicity of the monomeric complexes and which dimerize to the right-handed (ΔΔ) helicate [32]. As the process is slow, the mixture of the ammonium salt and complex was stirred for two weeks at room temperature in methanol. Thereafter, the solvent was removed and the Diels–Alder reaction with N-benzylmaleimide was performed at elevated temperature in THF. The reaction yielded the racemic product after purification. Scheme 3 is showing that the induction of stereochemistry of the Diels–Alder reaction depends on the chirality at the chiral ligand and not at the helix. This allows improvement of the stereoselectivity by using more appropriate sterically hindered or rigid chiral ligands. In addition, a solvent screening was performed in which solvents were used which favor the dimer. This is imminent for good enantioselectivities because the presence of a high amount of stereolabile monomer switches off the selectivity [13].

[1860-5397-16-195-i3]

Scheme 3: Elucidating the pathway of the stereoinduction of the Diels–Alder reaction. Ten equivalents of chiral ammonium salt are added to the hierarchical helicate in methanol and stirred for two weeks. Afterwards methanol is removed and the residue is dissolved in THF to perform a Diels–Alder reaction at the side chain.

Solvent dependence

Initially the solvent dependence of the stereochemical induction of the Diels–Alder reaction by the phenylethyl-derived ligand 2 was studied using N-benzylmaleimide (8e) as dienophile (Table 1). The solvents dioxane (17% ee) and acetone (14% ee) showed a slight decrease of the enantioselectivity compared to THF (21% ee). The yields of the reactions were rather moderate. On the other hand, the use of acetonitrile had no significant influence on the yield compared to acetone while the enantioselectivity dramatically dropped to 8% ee. In this case the lower selectivity correlated with the increasing lithium solvating capability of the solvent resulting in a higher proportion of the monomer and thus in lower stereoselectivities. In contrast to this, less polar solvents such as dichloromethane and chloroform resulted in increasing stereoselectivities in the Diels–Alder reaction due to their poor ability to stabilize lithium cations. Chloroform showed the best induction with 32% ee followed by dichloromethane with 25% ee, both with 50% yield (Table 1).

Table 1: Optimization of the stereoselectivity achieved of the Diels-Alder reaction at hierarchical helicates with solvent and chiral ligand screening.

[Graphic 1]
Entry L* 9 R solvent T
[°C] 		yield
[%] 		ee
[%]
1 2 e Bz THF 70 77 [13] 21 [13]
2 2 e Bz dioxane 105 53 17
3 2 e Bz acetone 60 50 14
4 2 e Bz MeCN 86 44 8
5 2 e Bz DCM 44 50 25
6 2 e Bz CHCl3 65 50 32
7 3 e Bz CHCl3 65 71 44
8 4 e Bz CHCl3 65 64 58
9 5 e Bz CHCl3 65 61 46
10 6 e Bz CHCl3 65 64 16
11 7 e Bz CHCl3 65 11 −8
12 4 a Me CHCl3 65 76 43
13 4 b Et CHCl3 65 79 39
14 4 c t-Bu CHCl3 65 82 18
15 4 d Cy CHCl3 65 80 49

aReactions performed in closed tubes.

Ligand screening

In a second optimization step, the chiral ligands have been varied. An increase of stereoselectivity was achieved by using the helicates with a statistical ligand distribution Li[Li3(1)3(L*)3Ti2] (L* = 3–7-H2). The given formula only describes the ratio of the ligands but in fact a statistical mixture of complexes Li[Li3(L*)6Ti2], Li[Li3(1)(L*)5Ti2], Li[Li3(1)2(L*)4Ti2], Li[Li3(1)3(L*)3Ti2], Li[Li3(1)4(L*)2Ti2], Li[Li3(1)5(L*)1Ti2], and Li[Li3(1)6Ti2] is present. Expanding the aromatic unit to a naphthyl group in 3-H2 resulted in an increase of the enantioselectivity to 44% ee. Even better selectivities were obtained with 4-H2 bearing an indanyl [33,34] substituent which combines a stereogenic center implemented in a ring system providing rigidity as well as an aromatic residue. The enantioselectivity increased to 58% ee (Table 1).

Besides the aromatic ligands, terpenyl-substituted ligands were investigated, too. The largest ligand 7-H2 with a cholesteryl moiety favored the opposite enantiomer, however, only with −8% ee in only 11% yield. The low yield may be attributed to the poor solubility of the helicate. The other terpene [35,36] derived systems Li[Li3(1)3(5)3Ti2] and Li[Li3(1)3(6)3Ti2] showed a different behavior. The (1S,2S,3S,5R)-3-pinanyl-substituted Li[Li3(1)3(5)3Ti2] yielded 46% ee, while the complex bearing a ʟ-(−)-borneyl residue Li[Li3(1)3(6)3Ti2] showed only 16% ee. The yields were higher than 60%. A possible reason for the significant drop in enantioselectivity by switching from ligand 5 to 6 was due to the different dimerization behavior. The homoleptic helicate Li[Li3(6)6Ti2] shows a lower dimerization tendency compared to Li[Li3(5)6Ti2] [35,36]. Thus, the higher amount of undesired monomer in solution of Li[Li3(1)3(6)3Ti2] resulted in a partial switch-off of the stereoselectivity.

Screening of the dienophile

The variation of the dienophile was studied in chloroform using the helicate Li4[(1)3(4)3Ti2]. N-Maleimides 8a and 8b with a methyl and an ethyl residue showed higher yields and a lower induction in comparison to the benzyl derivative 8e with 43% ee and 39% ee (Table 1). The poorest result was obtained by using dienophile 8c with a tert-butyl substituent (82% yield, 18% ee). This maleimide gave the lowest induction in our previous work, too [13]. Thus, no improvement was made in comparison to the 15% ee [13] achieved with chiral ligand 2-H2 in THF as solvent. The cyclohexyl-substituted dienophile 8d showed a higher induction (49% ee and 80% yield) than 8a and 8b, but could not reach the results of 8e. The described optimization of the reaction conditions based on solvent, chiral ligand, and substituent at the dienophile resulted in a nearly threefold increase of the enantioselectivity compared to the earlier described results [13].

The screening showed the opportunity to use hierarchically formed helicates with mixtures of ligands as platforms to control the stereochemistry of C–C bond-forming reactions. However, it would be of great advantage to transfer the findings to catalytic C–C bond-forming reactions which are catalyzed by hierarchical helicates containing chiral ligands for stereocontrol and achiral catalytically active ligands.

Enamine-catalyzed nitro-Michael reactions

The nitro-Michael reaction [37-40] seemed to be suitable to be performed at hierarchically assembled helicates due to the reaction’s “benchmark character” [41]. Therefore, ligands bearing secondary amine residues were introduced instead of the diene ligands. Again helicates with a statistical distribution of chiral ligands and of the new amine ligands in the complex were investigated as catalysts. The ligands with potential catalytic activity were synthesized in a three-step approach (Scheme 4). Initially the amino alcohols 10a–d were protected with a Boc group [42,43]. Esterification of the protected alcohols 11a–d [33,44] with 2,3-dioxosulfinylbenzoyl chloride obtained from 2,3-dihydroxybenzoic acid and thionyl chloride afforded the N-Boc-substituted catechol ligands 12a–d [33,36]. They were deprotected under acidic conditions with hydrochloric acid yielding ligands 13a–d-H2 [33,36] as ammonium chloride salts.

[1860-5397-16-195-i4]

Scheme 4: Synthesis of the ligands with secondary amine-containing substituents.

The obtained ligands 13a–d-H2 were used together with the chiral ligands 2,4,5-H2 for the formation of hierarchical helicates with a statistical ligand ratio which were formed from 1 equivalent of 13-H2 and 5 equivalents of 2-H2, 4-H2, and 5-H2.

The catalytic activity of the amine ligands was tested first by using the uncoordinated ligand 13a-H2 substituted with a N-methylethylamine moiety. The reaction was performed in DMSO-d6 due to solubility limitations of the ligand. Fast and easy measurement of the yield and the diastereoselectivity was possible by NMR spectroscopy. The nitro-Michael reaction of 3 equivalents propanal (14) and β-nitrostyrene (15) with 25 mol % of 13a-H2 after 2 days at room temperature resulted in 45% yield of product 16 and a nearly 1:1 diastereomeric ratio (Table 2).

Table 2: Enamine-catalyzed nitro-Michael reaction with hierarchically assembled helicates.a

[Graphic 2]
Entry catalyst mol % T
[°C] 		t
[d] 		yield
[%] 		dr
1b 13a-H2 25 rt 2 45c 52:48c
2 Li4[(13a)1(2)5Ti2] 15 rt 3 0 –
3 Li4[(13b)1(2)5Ti2] 15 rt 3 88 83:17
4 Li4[(13b)1(2)5Ti2] 15 0 7 71 87:13
5 Li4[(13b)1(2)5Ti2] 7.5 70 1 48 65:35
6 Li4[(13c)1(2)5Ti2] 15 rt 3 0 –
7 Li4[(13d)1(2)5Ti2] 15 rt 3 0 –
8 Li4[(13b)1(4)5Ti2] 15 rt 3 13 80:20
9 Li4[(13b)1(5)5Ti2] 15 rt 3 27 80:20

aNo enantioselectivity was achieved. bReaction was performed in DMSO-d6 (0.26 M) due to solubility limitations of the free ligand with 3 equiv of propanal. cValues determined by integration of the crude NMR spectrum of the reaction.

Catalysis at the “statistical” helicates was carried out with 5 equivalents of propanal (14) in order to gain a higher conversion. Beside a significant control over the diastereomeric ratio no enantioselectivity was achieved with helicates as catalysts. Catalysts at concentrations of 15 mol % were used in CDCl3 at room temperature and 0 °C with three or seven days of reaction time. The conversion was controlled by NMR spectroscopy and TLC. The helicate Li4[(13a)1(2)5Ti2] did not lead to any conversion at room temperature (Table 2). The catalyst Li4[(13b)1(2)5Ti2] with an ethyl-substituted amine worked well resulting in 88% yield and 66% de at room temperature. The diastereomeric excess increased slightly to a maximum of 74% de (dr 87:13) at 0 °C. A dramatic decrease to 30% de was observed by lowering the catalyst loading to 7.5 mol % while increasing the temperature to 70 °C. No enantioselectivity was observed using the helicate Li4[(13b)1(2)5Ti2] as catalyst. The helicates Li4[(13c)1(2)5Ti2] and Li4[(13d)1(2)5Ti2] with an isopropyl-substituted ethylamine and a cyclic secondary amine ligand as catalytically active unit showed no conversion in the nitro-Michael reaction. Solubility problems were the supposed reason for this observation. Thus, the amine ligand 13b-H2 seemed to be an appropriate component to make helicates from ligand mixtures which possess catalytic activity.

Exchange of the chiral ligand 2 by other chiral ones resulted in the corresponding complexes Li4[(13b)1(4)5Ti2] and Li4[(13b)1(5)5Ti2], but did not lead to a control of enantioselectivity. A reasonable diastereoselectivity of 60% de was observed for both catalysts. The limited solubility of these complexes caused a significant reduction of the yield at room temperature and due to this the reaction was not performed at lower temperatures.

Conclusion

An optimization of the Diels–Alder reaction taking place in the periphery of hierarchically assembled helicates was carried out. It was based on the elucidated induction pathway showing that the stereoselectivity was due to the proximity of the chiral units of ligand 2 to the diene unit. The helicity of the helicate did not have a significant influence. After optimization of solvent, chiral ligand, and substituent at the dienophile stereoselectivity was nearly tripled. Up to 58% ee was achieved in the Diels–Alder reaction in chloroform with the indanyl-substituted chiral ligand 4-H2 and N-benzylmaleimide (8e) as the dienophile.

In addition, the transition from the stoichiometric Diels–Alder reaction to a catalytic nitro-Michael reaction was described utilizing secondary amine ligands as catalysts. Only amine ligand 13b-H2 seemed suitable in the catalysis with the corresponding statistical helicates. With other complexes solubility problems arose. Li4[(13b)1(2)5Ti2] was the most efficient catalyst discussed in this study and provided good yields of up to 88% at room temperature. Suitable diastereoselectivities were obtained with up to 74% de (dr 87:13) at 0 °C and 66% de (dr 83:17) at room temperature. Enantioselectivity was not achieved even with the chiral ligands 4-H2 and 5-H2.

Nevertheless, the successful implementation of diastereoselective catalysis by hierarchically assembled helicates was a big step forward and will draw our focus on the development of new systems possessing catalytic activity with improved solubility.

Supporting Information

Supporting Information File 1: Synthetic procedures, characterization data, SFC and HPLC conditions and copies of 1H and 13C NMR spectra of new compounds.
Format: PDF Size: 2.0 MB Download

Acknowledgements

We sincerely thank Prof. Magnus Rüping, Cornelia Vermeeren, Prof. Carsten Bolm and Marcus Frings for the determination of the enantio- and diastereoselectivities via SFC and HPLC. Parts of this publication have been published in the Ph.D. thesis [33] of Dr. David Van Craen.

Funding

Support by the international graduate school SeleCa – Selectivity in Chemo- and Biocatalysis of the DFG (Deutsche Forschungsgemeinschaft) is gratefully acknowledged.

References

  1. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry, 2nd ed.; Oxford University Press: Oxford, U.K., 2012.
    Return to citation in text: [1]
  2. Brookes, J. C.; Horsfield, A. P.; Stoneham, A. M. J. R. Soc., Interface 2009, 6, 75–86. doi:10.1098/rsif.2008.0165
    Return to citation in text: [1]
  3. Corey, E. J.; Ensley, H. E. J. Am. Chem. Soc. 1975, 97, 6908–6909. doi:10.1021/ja00856a074
    Return to citation in text: [1]
  4. Enders, D.; Eichenauer, H. Angew. Chem. 1976, 88, 579–581. doi:10.1002/ange.19760881710
    Return to citation in text: [1]
  5. Evans, D. A.; Bartroli, J.; Shih, T. L. J. Am. Chem. Soc. 1981, 103, 2127–2129. doi:10.1021/ja00398a058
    Return to citation in text: [1]
  6. Roos, G., Ed. Key Chiral Auxiliary Applications, 2nd ed.; Academic Press: Boston, MA, USA, 2014. doi:10.1016/c2011-1-05800-9
    Return to citation in text: [1]
  7. Gnas, Y.; Glorius, F. Synthesis 2006, 1899–1930. doi:10.1055/s-2006-942399
    Return to citation in text: [1]
  8. Mikami, K.; Lautens, M., Eds. New frontiers in asymmetric catalysis; John Wiley & Sons: Hoboken, NJ, USA, 2007.
    Return to citation in text: [1]
  9. Yoshizawa, M.; Tamura, M.; Fujita, M. Science 2006, 312, 251–254. doi:10.1126/science.1124985
    Return to citation in text: [1]
  10. Wiester, M. J.; Ulmann, P. A.; Mirkin, C. A. Angew. Chem., Int. Ed. 2011, 50, 114–137. doi:10.1002/anie.201000380
    Return to citation in text: [1]
  11. Fang, Y.; Powell, J. A.; Li, E.; Wang, Q.; Perry, Z.; Kirchon, A.; Yang, X.; Xiao, Z.; Zhu, C.; Zhang, L.; Huang, F.; Zhou, H.-C. Chem. Soc. Rev. 2019, 48, 4707–4730. doi:10.1039/c9cs00091g
    Return to citation in text: [1]
  12. Zhao, C.; Toste, F. D.; Raymond, K. N.; Bergman, R. G. J. Am. Chem. Soc. 2014, 136, 14409–14412. doi:10.1021/ja508799p
    Return to citation in text: [1]
  13. Van Craen, D.; Albrecht, M.; Raabe, G.; Pan, F.; Rissanen, K. Chem. – Eur. J. 2016, 22, 3255–3258. doi:10.1002/chem.201600158
    Return to citation in text: [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12]
  14. Albrecht, M.; Mirtschin, S.; de Groot, M.; Janser, I.; Runsink, J.; Raabe, G.; Kogej, M.; Schalley, C. A.; Fröhlich, R. J. Am. Chem. Soc. 2005, 127, 10371–10387. doi:10.1021/ja052326j
    Return to citation in text: [1]
  15. Albrecht, M.; Baumert, M.; Klankermayer, J.; Kogej, M.; Schalley, C. A.; Fröhlich, R. Dalton Trans. 2006, 4395–4400. doi:10.1039/b607295j
    Return to citation in text: [1]
  16. Albrecht, M.; Fiege, M.; Baumert, M.; de Groot, M.; Fröhlich, R.; Russo, L.; Rissanen, K. Eur. J. Inorg. Chem. 2007, 609–616. doi:10.1002/ejic.200600852
    Return to citation in text: [1]
  17. Baumert, M.; Albrecht, M.; Winkler, H. D. F.; Schalley, C. A. Synthesis 2010, 953–958. doi:10.1055/s-0029-1218684
    Return to citation in text: [1]
  18. Albrecht, M.; Isaak, E.; Baumert, M.; Gossen, V.; Raabe, G.; Fröhlich, R. Angew. Chem. 2011, 123, 2903–2906. doi:10.1002/ange.201006448
    Angew. Chem., Int. Ed. 2011, 50, 2850–2853. doi:10.1002/anie.201006448
    Return to citation in text: [1]
  19. Van Craen, D.; de Groot, M.; Albrecht, M.; Pan, F.; Rissanen, K. Z. Anorg. Allg. Chem. 2015, 641, 2222–2227. doi:10.1002/zaac.201500543
    Return to citation in text: [1]
  20. Van Craen, D.; Rath, W. H.; Huth, M.; Kemp, L.; Räuber, C.; Wollschläger, J. M.; Schalley, C. A.; Valkonen, A.; Rissanen, K.; Albrecht, M. J. Am. Chem. Soc. 2017, 139, 16959–16966. doi:10.1021/jacs.7b10098
    Return to citation in text: [1]
  21. Chakrabarty, R.; Stang, P. J. J. Am. Chem. Soc. 2012, 134, 14738–14741. doi:10.1021/ja3070073
    Return to citation in text: [1]
  22. Wang, M.; Lan, W.-J.; Zheng, Y.-R.; Cook, T. R.; White, H. S.; Stang, P. J. J. Am. Chem. Soc. 2011, 133, 10752–10755. doi:10.1021/ja204155r
    Return to citation in text: [1]
  23. van Leeuwen, P. W. N. M.; Rivillo, D.; Raynal, M.; Freixa, Z. J. Am. Chem. Soc. 2011, 133, 18562–18565. doi:10.1021/ja207912d
    Return to citation in text: [1]
  24. Ohmatsu, K.; Ito, M.; Kunieda, T.; Ooi, T. Nat. Chem. 2012, 4, 473–477. doi:10.1038/nchem.1311
    Return to citation in text: [1]
  25. Ohmatsu, K.; Hara, Y.; Ooi, T. Chem. Sci. 2014, 5, 3645–3650. doi:10.1039/c4sc01032a
    Return to citation in text: [1]
  26. Kokan, Z.; Glasovac, Z.; Majerić Elenkov, M.; Gredičak, M.; Jerić, I.; Kirin, S. I. Organometallics 2014, 33, 4005–4015. doi:10.1021/om5005385
    Return to citation in text: [1]
  27. Zwick, B. D.; Arif, A. M.; Patton, A. T.; Gladysz, J. A. Angew. Chem. 1987, 99, 921–922. doi:10.1002/ange.19870990914
    Return to citation in text: [1]
  28. Dydio, P.; Dzik, W. I.; Lutz, M.; de Bruin, B.; Reek, J. N. H. Angew. Chem., Int. Ed. 2011, 50, 396–400. doi:10.1002/anie.201005173
    Return to citation in text: [1]
  29. Liao, S.; Sun, X.-L.; Tang, Y. Acc. Chem. Res. 2014, 47, 2260–2272. doi:10.1021/ar800104y
    Return to citation in text: [1]
  30. Wieland, J.; Breit, B. Nat. Chem. 2010, 2, 832–837. doi:10.1038/nchem.800
    Return to citation in text: [1]
  31. Gianneschi, N. C.; Bertin, P. A.; Nguyen, S. T.; Mirkin, C. A.; Zakharov, L. N.; Rheingold, A. L. J. Am. Chem. Soc. 2003, 125, 10508–10509. doi:10.1021/ja035621h
    Return to citation in text: [1]
  32. Albrecht, M.; Isaak, E.; Moha, V.; Raabe, G.; Fröhlich, R. Chem. – Eur. J. 2014, 20, 6650–6658. doi:10.1002/chem.201402370
    Return to citation in text: [1] [2]
  33. Van Craen, D. Hierarchisch gebildete Helicate als Plattform für stereoselektive Reaktionen und Katalyse. Ph.D. Thesis, RWTH Aachen University,, Aachen, Germany, 2017.
    Return to citation in text: [1] [2] [3] [4] [5]
  34. Teitelbaum, A. M.; Meissner, A.; Harding, R. A.; Wong, C. A.; Aldrich, C. C.; Remmel, R. P. Bioorg. Med. Chem. 2013, 21, 5605–5617. doi:10.1016/j.bmc.2013.05.024
    See for the synthesis of the required (S)-1-indany.
    Return to citation in text: [1]
  35. Albrecht, M.; Isaak, E.; Shigemitsu, H.; Moha, V.; Raabe, G.; Fröhlich, R. Dalton Trans. 2014, 43, 14636–14643. doi:10.1039/c4dt01553c
    Return to citation in text: [1] [2]
  36. Isaak, E. Stereoselektive hierarchische Selbstorganisation von Helicaten. Ph.D. Thesis, RWTH Aachen University, Aachen, Germany, 2013.
    Return to citation in text: [1] [2] [3] [4]
  37. Seebach, D.; Goliński, J. Helv. Chim. Acta 1981, 64, 1413–1423. doi:10.1002/hlca.19810640518
    Return to citation in text: [1]
  38. Blarer, S. J.; Schweizer, W. B.; Seebach, D. Helv. Chim. Acta 1982, 65, 1637–1654. doi:10.1002/hlca.19820650537
    Return to citation in text: [1]
  39. Hayashi, Y.; Gotoh, H.; Hayashi, T.; Shoji, M. Angew. Chem., Int. Ed. 2005, 44, 4212–4215. doi:10.1002/anie.200500599
    Return to citation in text: [1]
  40. Burés, J.; Armstrong, A.; Blackmond, D. G. J. Am. Chem. Soc. 2011, 133, 8822–8825. doi:10.1021/ja203660r
    Return to citation in text: [1]
  41. Burés, J.; Armstrong, A.; Blackmond, D. G. J. Am. Chem. Soc. 2012, 134, 6741–6750. doi:10.1021/ja300415t
    Return to citation in text: [1]
  42. Krapcho, A. P.; Maresch, M. J.; Lunn, J. Synth. Commun. 1993, 23, 2443–2449. doi:10.1080/00397919308011130
    Return to citation in text: [1]
  43. Saari, W. S.; Schwering, J. E.; Lyle, P. A.; Smith, S. J.; Engelhardt, E. L. J. Med. Chem. 1990, 33, 97–101. doi:10.1021/jm00163a016
    Return to citation in text: [1]
  44. Chang, D.; Feiten, H.-J.; Engesser, K.-H.; van Beilen, J. B.; Witholt, B.; Li, Z. Org. Lett. 2002, 4, 1859–1862. doi:10.1021/ol025829s
    Return to citation in text: [1]

© 2020 Van Craen et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)

Other Beilstein-Institut Open Science Activities
Journal Logo
Institut Logo
Preprint Logo
Symposia Logo