Supporting Information
Materials and methods and detailed synthetic procedures and spectroscopic data of all compounds. Figure S1: ORTEP-type plot of the molecular structure of 3a, Figures S2–S25: NMR spectra, Tables S1–S3: Crystal data and structure refinement for compound 3a.
| Supporting Information File 1: Experimental and analytical data. | ||
| Format: PDF | Size: 7.7 MB | Download |
Cite the Following Article
Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K2CO3/n-Bu4PBr in water
Thanigaimalai Pillaiyar, Masoud Sedaghati and Gregor Schnakenburg
Beilstein J. Org. Chem. 2020, 16, 778–790.
https://doi.org/10.3762/bjoc.16.71
How to Cite
Pillaiyar, T.; Sedaghati, M.; Schnakenburg, G. Beilstein J. Org. Chem. 2020, 16, 778–790. doi:10.3762/bjoc.16.71
Download Citation
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window
below.
Citation data in RIS format can be imported by all major citation management software, including EndNote,
ProCite, RefWorks, and Zotero.
Presentation Graphic
| Picture with graphical abstract, title and authors for social media postings and presentations. | ||
| Format: PNG | Size: 158.2 KB | Download |
Citations to This Article
Up to 20 of the most recent references are displayed here.
Scholarly Works
- Pang, Q.; Zuo, W.-F.; Zhang, Y.; Li, X.; Han, B. Recent Advances on Direct Functionalization of Indoles in Aqueous Media. Chemical record (New York, N.Y.) 2023, 23, e202200289. doi:10.1002/tcr.202200289
- Wu, X.-T.; Ma, F.; Xiao, E.-K.; Yin, J.; Sun, F.; Wang, Q.; Jiang, Y.-J.; Chen, P. One-pot synthesis of tri- and di-fluoromethylated bis(indolyl)methanols via Friedel-Crafts-type acylation and alkylation. Organic & biomolecular chemistry 2022, 20, 7491–7498. doi:10.1039/d2ob01281b
- Chigumbu, P.; Fu, J.; Takia, I. R. T.; Wang, Y.; Han, X. Friedel-Crafts Benzylation of Unprotected Anilines with Indole-3- carbinols to Access Trifluoro-methyl(indolyl)phenylmethanes. Letters in Organic Chemistry 2022, 19, 353–361. doi:10.2174/1570178618666210225114226
- Flury, P.; Eppler, O.; Schollmeyer, D.; Laufer, S.; Pillaiyar, T. 2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes. Archiv der Pharmazie 2022, 355, e2100488. doi:10.1002/ardp.202100488
- Duvauchelle, V.; Bénimélis, D.; Meffre, P.; Benfodda, Z. Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution. Molecules (Basel, Switzerland) 2022, 27, 925. doi:10.3390/molecules27030925
- Pillaiyar, T.; Sedaghati, M.; Mahardhika, A. B.; Wendt, L. L.; Müller, C. E. Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center. Beilstein journal of organic chemistry 2021, 17, 1464–1475. doi:10.3762/bjoc.17.102
- Mondal, D.; Kalar, P. L.; Kori, S.; Gayen, S.; Das, K. Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications. Current Organic Chemistry 2020, 24, 2665–2693. doi:10.2174/1385272824999201111203812
- Guidotti, B. B.; Silva, T. S.; Correia, J. T. M.; Coelho, F. Brønsted-acid-catalyzed selective Friedel-Crafts monoalkylation of isatins with indolizines in water. Organic & biomolecular chemistry 2020, 18, 7330–7335. doi:10.1039/d0ob01714k
