Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center

Thanigaimalai Pillaiyar, Masoud Sedaghati, Andhika B. Mahardhika, Lukas L. Wendt and Christa E. Müller
Beilstein J. Org. Chem. 2021, 17, 1464–1475. https://doi.org/10.3762/bjoc.17.102

Supporting Information

Supporting Information File 1: Experimental and analytical data.
Format: PDF Size: 8.2 MB Download

Cite the Following Article

Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center
Thanigaimalai Pillaiyar, Masoud Sedaghati, Andhika B. Mahardhika, Lukas L. Wendt and Christa E. Müller
Beilstein J. Org. Chem. 2021, 17, 1464–1475. https://doi.org/10.3762/bjoc.17.102

How to Cite

Pillaiyar, T.; Sedaghati, M.; B. Mahardhika, A.; L. Wendt, L.; E. Müller, C. Beilstein J. Org. Chem. 2021, 17, 1464–1475. doi:10.3762/bjoc.17.102

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 9.5 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Sun, Z.; Liu, J.; Shi, L.; Yang, M.; Wang, Y.; Han, Y.; Yao, X.; Liang, Y. New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters. Advanced Synthesis & Catalysis 2024, 366, 4294–4322. doi:10.1002/adsc.202400732
  • Teli, P.; Soni, S.; Teli, S.; Agarwal, S. Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes. Topics in current chemistry (Cham) 2024, 382, 8. doi:10.1007/s41061-024-00454-z
  • Mahardhika, A. B.; Ressemann, A.; Kremers, S. E.; Gregório Castanheira, M. S.; Schoeder, C. T.; Müller, C. E.; Pillaiyar, T. Design, synthesis, and structure-activity relationships of diindolylmethane derivatives as cannabinoid CB2 receptor agonists. Archiv der Pharmazie 2022, 356, e2200493. doi:10.1002/ardp.202200493
  • Zhang, W.; Vadlakonda, S.; Wu, M.; Chintareddy, V.; Vogeti, L. N.; Juarez, L.; Muppa, S.; Parker, C.; Kellogg-Yelder, D.; Williams, J.; Polach, K.; Chen, X.; Raman, K.; Babu, Y. S.; Kotian, P. Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon. Bioorganic & medicinal chemistry 2022, 73, 117035. doi:10.1016/j.bmc.2022.117035
  • Flury, P.; Eppler, O.; Schollmeyer, D.; Laufer, S.; Pillaiyar, T. 2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes. Archiv der Pharmazie 2022, 355, e2100488. doi:10.1002/ardp.202100488
  • Modemann, D. J.; Mahardhika, A. B.; Yamoune, S.; Kreyenschmidt, A.-K.; Maaß, F.; Kremers, S.; Breunig, C.; Sahlmann, C.-O.; Bucerius, J.; Stalke, D.; Wiltfang, J.; Bouter, Y.; Müller, C. E.; Bouter, C.; Meller, B. Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a radioactive tracer for imaging. European journal of medicinal chemistry 2022, 232, 114138. doi:10.1016/j.ejmech.2022.114138
Other Beilstein-Institut Open Science Activities