Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

Virginija Jakubkiene, Gabrielius Ernis Valiulis, Markus Schweipert, Asta Zubriene, Daumantas Matulis, Franz-Josef Meyer-Almes and Sigitas Tumkevicius
Beilstein J. Org. Chem. 2022, 18, 837–844. https://doi.org/10.3762/bjoc.18.84

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Supporting Information File 1: Compounds characterization and analytical data; HDAC enzyme activity assay; references; NMR spectra.
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Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids
Virginija Jakubkiene, Gabrielius Ernis Valiulis, Markus Schweipert, Asta Zubriene, Daumantas Matulis, Franz-Josef Meyer-Almes and Sigitas Tumkevicius
Beilstein J. Org. Chem. 2022, 18, 837–844. https://doi.org/10.3762/bjoc.18.84

How to Cite

Jakubkiene, V.; Valiulis, G. E.; Schweipert, M.; Zubriene, A.; Matulis, D.; Meyer-Almes, F.-J.; Tumkevicius, S. Beilstein J. Org. Chem. 2022, 18, 837–844. doi:10.3762/bjoc.18.84

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  • Jakubkiene, V.; Labalaukyte, I.; Schweipert, M.; Zubriene, A.; Meyer‐Almes, F.; Matulis, D.; Tumkevicius, S. Synthesis and histone deacetylases inhibitory activity of pyrimidine‐based 1,3,4‐oxadiazoles. Journal of Heterocyclic Chemistry 2024, 61, 1426–1438. doi:10.1002/jhet.4867
  • Aslanoglu, F.; Yazıcı, A. 6-methylthiouracil and 6-methyluracil derivatives synthesized by reaction of acetylketene with thiourea and urea compounds in presence of Yb(TFA)3. Synthetic Communications 2023, 53, 1713–1721. doi:10.1080/00397911.2023.2245506
  • Badran, M. M.; Abbas, S. H.; Fujita, M.; Abdel-Aziz, M. Harnessing pyrimidine as a building block for histone deacetylase inhibitors. Archiv der Pharmazie 2023, 356, e2300208. doi:10.1002/ardp.202300208
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