Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

Scholarly Works

• Kesel, A. J. Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells. Molecules (Basel, Switzerland) 2024, 29, 914. doi:10.3390/molecules29040914
• Nudelman, A. Mutual Prodrugs - Codrugs. Current medicinal chemistry 2023, 30, 4283–4339. doi:10.2174/0929867330666221209102650
• Zefirov, N. A.; Mamaeva, A. V.; Radchenko, E.; Milaeva, E. R.; Kuznetsov, S. A.; Zefirova, O. N. Conjugate of podophyllotoxin with chlorambucil: synthesis, biological testing and molecular modeling. Biomeditsinskaia khimiia 2021, 67, 289–294. doi:10.18097/pbmc20216703289
• Škubník, J.; Pavlíčková, V.; Ruml, T.; Rimpelová, S. Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy. Plants (Basel, Switzerland) 2021, 10, 569. doi:10.3390/plants10030569
• Girola, N.; Resende-Lara, P. T.; Figueiredo, C. R.; Massaoka, M. H.; Azevedo, R. A.; Cunha, R. L. O. R.; Polonelli, L.; Travassos, L. R. Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells. Frontiers in oncology 2019, 9, 25. doi:10.3389/fonc.2019.00025
• Kurek, J. Cytotoxic Colchicine Alkaloids: From Plants to Drugs. Cytotoxicity; InTech, 2018. doi:10.5772/intechopen.72622
• Ghawanmeh, A. A.; Chong, K. F.; Sarkar, S. M.; Abu Bakar, M.; Othaman, R.; Khalid, R. M. Colchicine prodrugs and codrugs: Chemistry and bioactivities. European journal of medicinal chemistry 2017, 144, 229–242. doi:10.1016/j.ejmech.2017.12.029
• Dubey, K. K.; Kumar, P.; Labrou, N. E.; Shukla, P. Biotherapeutic potential and mechanisms of action of colchicine. Critical reviews in biotechnology 2017, 37, 1038–1047. doi:10.1080/07388551.2017.1303804
• Liu, J.; Pang, Y.; Bhattacharyya, J.; Liu, W.; Weitzhandler, I.; Li, X.; Chilkoti, A. Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug. Advanced healthcare materials 2016, 5, 1868–1873. doi:10.1002/adhm.201600230
• Bhattacharyya, J.; Bellucci, J. J.; Weitzhandler, I.; McDaniel, J. R.; Spasojevic, I.; Li, X.; Lin, C.-C.; Ashley, J.-T.; Chilkoti, A. A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. Nature communications 2015, 6, 7939. doi:10.1038/ncomms8939
• Vilanova, C.; Díaz-Oltra, S.; Murga, J.; Falomir, E.; Carda, M.; Redondo-Horcajo, M.; Díaz, J. F.; Barasoain, I.; Marco, J. A. Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. Journal of medicinal chemistry 2014, 57, 10391–10403. doi:10.1021/jm501112q
• Erfani, M.; Shamsaei, M.; Mohammadbaghery, F.; Shirmardi, S. P. Synthesis and evaluation of a 99mTc-labeled tubulin-binding agent for tumor imaging. Journal of labelled compounds & radiopharmaceuticals 2014, 57, 419–424. doi:10.1002/jlcr.3200
• Oltra, D.; Clausell, M.; Ventura, F.; Horcajo, R.; Díaz, F.; Barasoain, I.; Marco, A.
• Nacoulma, A. P.; Megalizzi, V.; Pottier, L.; De Lorenzi, M.; Thoret, S.; Dubois, J.; Vandeputte, O. M.; Duez, P.; Vereecke, D.; Jaziri, M. E. Potent Antiproliferative Cembrenoids Accumulate in Tobacco upon Infection with Rhodococcus fascians and Trigger Unusual Microtubule Dynamics in Human Glioblastoma Cells. PloS one 2013, 8, e77529. doi:10.1371/journal.pone.0077529
• Lin, P.-C.; Shen, C.-C.; Liao, C.-K.; Jow, G.-M.; Chiu, C.-T.; Chung, T.-H.; Wu, J. C. HYS-32, a novel analogue of combretastatin A-4, enhances connexin43 expression and gap junction intercellular communication in rat astrocytes. Neurochemistry international 2013, 62, 881–892. doi:10.1016/j.neuint.2013.02.027
• Lourenço, A.; Ferreira, L. M.; Branco, P. S. Molecules of Natural Origin, Semi-synthesis and Synthesis with Anti-Inflammatory and Anticancer Utilities. Current pharmaceutical design 2012, 18, 3979–4046. doi:10.2174/138161212802083644
• Malysheva, Y. B.; Combes, S.; Allegro, D.; Peyrot, V.; Knochel, P.; Gavryushin, A.; Fedorov, A. Y. Synthesis and biological evaluation of novel anticancer bivalent colchicine-tubulizine hybrids. Bioorganic & medicinal chemistry 2012, 20, 4271–4278. doi:10.1016/j.bmc.2012.05.072
• Crielaard, B. J.; van der Wal, S.; Le, H. T.; Bode, A.; Lammers, T.; Hennink, W. E.; Schiffelers, R. M.; Fens, M. H.; Storm, G. Liposomes as carriers for colchicine-derived prodrugs: Vascular disrupting nanomedicines with tailorable drug release kinetics. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011, 45, 429–435. doi:10.1016/j.ejps.2011.08.027
• Wardle, N. J.; Kalber, T. L.; Bell, J. D.; Bligh, S. W. A. Synthesis and characterisation of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features. Bioorganic & medicinal chemistry letters 2011, 21, 3346–3348. doi:10.1016/j.bmcl.2011.04.014
• Nicolaus, N.; Zapke, J.; Riesterer, P.; Neudörfl, J.-M.; Prokop, A.; Oschkinat, H.; Schmalz, H.-G. Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug. ChemMedChem 2010, 5, 661–665. doi:10.1002/cmdc.201000063

Explore citations to this article at