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Origami with small molecules: exploiting the C–F bond as a conformational tool

Patrick Ryan, Ramsha Iftikhar and Luke Hunter

Beilstein J. Org. Chem. 2025, 21, 680–716. https://doi.org/10.3762/bjoc.21.54

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Patrick Ryan, Ramsha Iftikhar and Luke Hunter

Beilstein J. Org. Chem. 2025, 21, 680–716. https://doi.org/10.3762/bjoc.21.54

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Ryan, P.; Iftikhar, R.; Hunter, L. Beilstein J. Org. Chem. 2025, 21, 680–716. doi:10.3762/bjoc.21.54

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TY  - JOUR
A1  - Ryan, Patrick
A1  - Iftikhar, Ramsha
A1  - Hunter, Luke
T1  - Origami with small molecules: exploiting the C–F bond as a conformational tool
JF  - Beilstein Journal of Organic Chemistry
PY  - 2025///
VL  - 21
SP  - 680
EP  - 716
SN  - 1860-5397
DO  - 10.3762/bjoc.21.54
PB  - Beilstein-Institut
JA  - Beilstein J. Org. Chem.
UR  - https://doi.org/10.3762/bjoc.21.54
KW  - conformational analysis
KW  - medicinal chemistry
KW  - organofluorine chemistry
KW  - stereoselective fluorination
N2  - When present within an organic molecule, the C–F bond tends to align in predictable ways with neighbouring functional groups, due to stereoelectronic effects such as hyperconjugation and electrostatic attraction/repulsion. These fluorine-derived conformational effects have been exploited to control the shapes, and thereby enhance the properties, of a wide variety of functional molecules including pharmaceutical agents, liquid crystals, fragrance chemicals, organocatalysts, and peptides. This comprehensive review summarises developments in this field during the period 2010–2024.
ER  -

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