Trifluoromethyl ethers – synthesis and properties of an unusual substituent

Scholarly Works

• Logvinenko, I. G.; Sadkova, I. V.; Tolmachova, N. A.; Shishkina, S. V.; Daniliuc, C. G.; Haufe, G.; Kondratov, I. S. 4-Trifluoromethoxy proline: synthesis of stereoisomers and lipophilicity study. Organic & biomolecular chemistry 2024, 22, 7982–7988. doi:10.1039/d4ob00688g
• Gao, G.; Xie, K.; Shi, M.; Gao, T.; Wang, Z.; Zhang, C.; Wang, Z. Direct trifluoromethylselenolations of electron-rich (hetero)aromatic rings with N-trifluoromethylselenolating saccharin. Organic & biomolecular chemistry 2024, 22, 7707–7714. doi:10.1039/d4ob01134a
• Liu, Y.; Sun, F.; Jia, B.; Wang, Z.; Yue, M.; Yang, L.; Fu, Y.; Ye, F. Novel (2,6-difluorobenzoyl)urea-activated fluorescent probe for fluorine-containing-pesticide detection. Journal of Environmental Chemical Engineering 2024, 12, 112786. doi:10.1016/j.jece.2024.112786
• Fritsch, S.; Strassner, T. Synthesis and physical properties of tunable aryl alkyl ionic liquids based on 1-aryl-4,5-dimethylimidazolium cations. Beilstein journal of organic chemistry 2024, 20, 1278–1285. doi:10.3762/bjoc.20.110
• Nisler, J.; Klimeš, P.; Končitíková, R.; Kadlecová, A.; Voller, J.; Chalaki, M.; Karampelias, M.; Murvanidze, N.; Werbrouck, S. P. O.; Kopečný, D.; Havlíček, L.; De Diego, N.; Briozzo, P.; Moréra, S.; Zalabák, D.; Spíchal, L. Cytokinin oxidase/dehydrogenase inhibitors: progress towards agricultural practice. Journal of experimental botany 2024, 75, 4873–4890. doi:10.1093/jxb/erae239
• Flemmich, L.; Bereiter, R.; Micura, R. Chemical Synthesis of Modified RNA. Angewandte Chemie (International ed. in English) 2024, 63, e202403063. doi:10.1002/anie.202403063
• Flemmich, L.; Bereiter, R.; Micura, R. Chemical Synthesis of Modified RNA. Angewandte Chemie 2024, 136. doi:10.1002/ange.202403063
• Craig, R. A.; De Vicente, J.; Estrada, A. A.; Feng, J. A.; Lexa, K. W.; Canet, M. J.; Dowdle, W. E.; Erickson, R. I.; Flores, B. N.; Haddick, P. C. G.; Kane, L. A.; Lewcock, J. W.; Moerke, N. J.; Poda, S. B.; Sweeney, Z.; Takahashi, R. H.; Tong, V.; Wang, J.; Yulyaningsih, E.; Solanoy, H.; Scearce-Levie, K.; Sanchez, P. E.; Tang, L.; Xu, M.; Zhang, R.; Osipov, M. Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases. Journal of medicinal chemistry 2024, 67, 5758–5782. doi:10.1021/acs.jmedchem.3c02422
• Cabrera, P. J.; Allais, C.; Arcari, J. T.; González-Esguevillas, M.; McInturff, E. L.; Reese, M. R. Rapid Multikilogram Scale-Up of Di- and Trifluoromethoxy Proline Derivatives. Organic Process Research & Development 2024, 28, 1119–1128. doi:10.1021/acs.oprd.3c00493
• Ng, M. Y.; Song, Z. J.; Venkatesan, G.; Rodriguez-Cuenca, S.; West, J. A.; Yang, S.; Tan, C. H.; Ho, P. C.-L.; Griffin, J. L.; Vidal-Puig, A.; Bassetto, M.; Hagen, T. Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation. Scientific reports 2024, 14, 4932. doi:10.1038/s41598-024-54466-2
• Fernandes, A. J.; Giri, R.; Houk, K. N.; Katayev, D. Review and Theoretical Analysis of Fluorinated Radicals in Direct CAr−H Functionalization of (Hetero)arenes. Angewandte Chemie 2024, 136. doi:10.1002/ange.202318377
• Fernandes, A. J.; Giri, R.; Houk, K. N.; Katayev, D. Review and Theoretical Analysis of Fluorinated Radicals in Direct CAr-H Functionalization of (Hetero)arenes. Angewandte Chemie (International ed. in English) 2024, 63, e202318377. doi:10.1002/anie.202318377
• Chen, X.; Xie, L.; Zhang, C.; Tian, S.; Tang, Z.; Xiang, M.; Tian, W.; Lu, P.; Yang, X. Synthesis of Nucleotides Bearing the 2'-O-Trifluoromethyl Group and Their Application in RNA Analogs Preparation. Current protocols 2024, 4, e956. doi:10.1002/cpz1.956
• Deng, Z.; Meng, L.; Bing, X.; Niu, S.; Zhang, X.; Peng, J.; Luan, Y.-X.; Chen, L.; Tang, P. Silver-Enabled Dearomative Trifluoromethoxylation of Indoles. Journal of the American Chemical Society 2024, 146, 2325–2332. doi:10.1021/jacs.3c11653
• Maas, L. M.; Fasting, C.; Voßnacker, P.; Limberg, N.; Golz, P.; Müller, C.; Riedel, S.; Hopkinson, M. N. Catalyst-Free Trifluoromethoxylation of Silyl Enol Ethers and Allyl Silanes with Bis(trifluoromethyl)peroxide. Angewandte Chemie (International ed. in English) 2024, 63, e202317770. doi:10.1002/anie.202317770
• Maas, L. M.; Fasting, C.; Voßnacker, P.; Limberg, N.; Golz, P.; Müller, C.; Riedel, S.; Hopkinson, M. N. Catalyst‐Free Trifluoromethoxylation of Silyl Enol Ethers and Allyl Silanes with Bis(trifluoromethyl)peroxide. Angewandte Chemie 2024, 136. doi:10.1002/ange.202317770
• Zheng, Y.; Wang, Q.; Che, Y.; Jiang, S.; Yu, Z.; Wang, Y.; Ma, Y.; Solan, G. A.; Liang, T.; Sun, W.-H. High molecular weight bimodal polyethylene elastomers using N,N'-nickel catalysts appended with methoxy and trifluoromethoxy functionality. European Polymer Journal 2024, 203, 112649. doi:10.1016/j.eurpolymj.2023.112649
• Song, D.; Zhao, H.; Xu, Y.; Ji, C.; Liu, Y. Advances in the Synthesis of Mono/Di/Polyfluoroalkyl Ethers. Chinese Journal of Organic Chemistry 2024, 44, 2174. doi:10.6023/cjoc202401003
• 梁, 燕. Research Progress in the Synthesis of OCF3 Compounds. Journal of Organic Chemistry Research 2024, 12, 60–73. doi:10.12677/jocr.2024.121005
• Sroor, F. M.; Mahrous, K. F.; El-Kader, H. A. M. A.; Othman, A. M.; Ibrahim, N. S. Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: synthesis, in-vitro, in-silico and SAR studies. Scientific reports 2023, 13, 17560. doi:10.1038/s41598-023-44753-9

Explore citations to this article at