Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}

Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus and Sean M. Kerwin
Beilstein J. Org. Chem. 2008, 4, No. 26. https://doi.org/10.3762/bjoc.4.26

Supporting Information

Supporting Information File 1: This file includes full experimental details for all new compounds.
Format: DOC Size: 83.0 KB Download
Supporting Information File 2: Copies of 1H and 13C NMR spectra of compounds 2b,c; 3ac; 5b,c; 6ac; A; 7a,b; 8ad; 9; and 10.
Format: DOC Size: 3.6 MB Download

Cite the Following Article

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}
Subrata Mandal, Wen Tai Li, Yan Bai, Jon D. Robertus and Sean M. Kerwin
Beilstein J. Org. Chem. 2008, 4, No. 26. https://doi.org/10.3762/bjoc.4.26

How to Cite

Mandal, S.; Li, W. T.; Bai, Y.; Robertus, J. D.; Kerwin, S. M. Beilstein J. Org. Chem. 2008, 4, No. 26. doi:10.3762/bjoc.4.26

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • De Coen, L. M.; Roman, B.; Movsisyan, M.; Heugebaert, T. S. A.; Stevens, C. V. Synthesis and Biological Activity of Oxazolopyrimidines. European Journal of Organic Chemistry 2018, 2018, 2148–2166. doi:10.1002/ejoc.201800133
  • Mieczkowski, A.; Bieszczad, B. Recent advances in the synthesis and applications of oxazolo[5,4-d]pyrimidines (microreview). Chemistry of Heterocyclic Compounds 2016, 52, 782–784. doi:10.1007/s10593-016-1965-9
  • Mistry, S. N.; Lim, H.; Jörg, M.; Capuano, B.; Christopoulos, A.; Lane, J. R.; Scammells, P. J. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor. ACS chemical neuroscience 2016, 7, 647–661. doi:10.1021/acschemneuro.6b00018
  • Zeng, G.-P.; Cai, C.-Q.; Tan, F.; Ding, M.-W. New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane. Chinese Chemical Letters 2015, 26, 1158–1160. doi:10.1016/j.cclet.2015.06.011
  • May, K. L.; Yan, Q.; Tumer, N. E. Targeting ricin to the ribosome. Toxicon : official journal of the International Society on Toxinology 2013, 69, 143–151. doi:10.1016/j.toxicon.2013.02.001
  • Bai, Y.; Watt, B.; Wahome, P. G.; Mantis, N. J.; Robertus, J. D. Identification of new classes of ricin toxin inhibitors by virtual screening. Toxicon : official journal of the International Society on Toxinology 2010, 56, 526–534. doi:10.1016/j.toxicon.2010.05.009

Patents

  • AJIAIKEBAIER AISA; ZENG YAN; NIE LIFEI; HUERXIDI BOZALUOFU; ZHAO JIANGYU. Dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidine-9(5H)-one derivative and application thereof. CN 112724157 A, April 30, 2021.
Other Beilstein-Institut Open Science Activities