From discovery to production: Scale-out of continuous flow meso reactors

Scholarly Works

• Polterauer, D.; Roberge, D. M.; Hanselmann, P.; Littich, R.; Hone, C. A.; Kappe, C. O. A continuous flow investigation of sulfonyl chloride synthesis using N-chloroamides: optimization, kinetics and mechanism. Reaction Chemistry & Engineering 2022, 7, 2582–2592. doi:10.1039/d2re00280a
• Beckers, O.; Smeets, S.; Lutsen, L.; Maes, W. Perspective on the application of continuous flow chemistry for polymer-based organic electronics. Journal of Materials Chemistry C 2022, 10, 1606–1616. doi:10.1039/d1tc04635g
• Hone, C. A.; Kappe, C. O. Towards the Standardization of Flow Chemistry Protocols for Organic Reactions. Chemistry–Methods 2021, 1, 454–467. doi:10.1002/cmtd.202100059
• Bálint, E.; Tajti, Á.; Keglevich, G. Application of the Microwave Technique in Continuous Flow Processing of Organophosphorus Chemical Reactions. Materials (Basel, Switzerland) 2019, 12, 788. doi:10.3390/ma12050788
• Biao, W.; Wang, Y.; Jiang, Y.; Chu, M.-M.; Qi, S.-S.; Ju, W.-Z.; Xu, D.-Q. Asymmetric fluorination of indanone-2-carboxylates using a polystyrene-supported diphenylamine-linked bis(oxazoline) complex. Organic & biomolecular chemistry 2018, 16, 7702–7710. doi:10.1039/c8ob01943f
• Tamborini, L.; Fernandes, P.; Paradisi, F.; Molinari, F. Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification. Trends in biotechnology 2017, 36, 73–88. doi:10.1016/j.tibtech.2017.09.005
• Pirotte, G.; Agarkar, S.; Xu, B.; Zhang, J.; Lutsen, L.; Vanderzande, D.; Yan, H.; Pollet, P.; Reynolds, J. R.; Maes, W.; Marder, S. R. Molecular weight tuning of low bandgap polymers by continuous flow chemistry: increasing the applicability of PffBT4T for organic photovoltaics. Journal of Materials Chemistry A 2017, 5, 18166–18175. doi:10.1039/c7ta05627c
• Degennaro, L.; Carlucci, C.; De Angelis, S.; Luisi, R. Flow technology for organometallic-mediated synthesis. Journal of Flow Chemistry 2016, 6, 136–166. doi:10.1556/1846.2016.00014
• Linares, N.; Moreno-Marrodan, C.; Barbaro, P. PdNP@Titanate Nanotubes as Effective Catalyst for Continuous-Flow Partial Hydrogenation Reactions. ChemCatChem 2016, 8, 1001–1011. doi:10.1002/cctc.201501126
• Güveli, Ş.; Cinar, S. A.; Karahan, O.; Aviyente, V.; Ülküseven, B. Nickel(II)–PPh3 Complexes of S,N‐Substituted Thiosemicarbazones – Structure, DFT Study, and Catalytic Efficiency. European Journal of Inorganic Chemistry 2016, 2016, 538–544. doi:10.1002/ejic.201501227
• Gürsel, I. V.; Kurt, S. K.; Aalders, J.; Wang, Q. Q.; Noël, T.; Nigam, K. D.; Kockmann, N.; Hessel, V. Utilization of milli-scale coiled flow inverter in combination with phase separator for continuous flow liquid-liquid extraction processes. Chemical Engineering Journal 2016, 283, 855–868. doi:10.1016/j.cej.2015.08.028
• Nagaki, A.; Yoshida, J.-i. Preparation and Use of Organolithium and Organomagnesium Species in Flow. Topics in Organometallic Chemistry; Springer International Publishing, 2015; pp 137–175. doi:10.1007/3418_2015_154
• Mitic, A.; Gernaey, K. V. Process Intensification Tools in the Small‐Scale Pharmaceutical Manufacturing of Small Molecules. Chemical Engineering & Technology 2015, 38, 1699–1712. doi:10.1002/ceat.201400765
• Ager, D. J. ACS Symposium Series - Managing Hazardous Reactions and Compounds in Process Chemistry. ACS Symposium Series; American Chemical Society, 2014; pp 285–351. doi:10.1021/bk-2014-1181.ch012
• Mitic, A.
• Cantillo, D.; Kappe, C. O. Immobilized Transition Metals as Catalysts for Cross‐Couplings in Continuous Flow—A Critical Assessment of the Reaction Mechanism and Metal Leaching. ChemCatChem 2014, 6, 3286–3305. doi:10.1002/cctc.201402483
• Manvar, A.; Shah, A. Continuous Flow and Microwave‐Assisted Vorbrüggen Glycosylations: Historical Perspective to High‐Throughput Strategies. Asian Journal of Organic Chemistry 2014, 3, 1134–1149. doi:10.1002/ajoc.201402119
• Eliasen, A. M.; Thedford, R. P.; Claussen, K. R.; Yuan, C.; Siegel, D. A Protocol To Generate Phthaloyl Peroxide in Flow for the Hydroxylation of Arenes. Organic letters 2014, 16, 3628–3631. doi:10.1021/ol501497y
• Egle, B.; de Muñoz, J. M.; Alonso, N.; De Borggraeve, W. M.; de la Hoz, A.; Díaz-Ortiz, A.; Alcázar, J. First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups. Journal of Flow Chemistry 2014, 4, 22–25. doi:10.1556/jfc-d-13-00009
• Nightingale, A. M.; Bannock, J. H.; Krishnadasan, S. H.; O'Mahony, F. T. F.; Haque, S. A.; Sloan, J.; Drury, C. J.; McIntyre, R.; deMello, J. C. Large-scale synthesis of nanocrystals in a multichannel droplet reactor. Journal of Materials Chemistry A 2013, 1, 4067–4076. doi:10.1039/c3ta10458c

Explore citations to this article at