Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Scholarly Works

• Eagling, L.; Leonard, D. J.; Schwarz, M.; Urruzuno, I.; Boden, G. K.; Wailes, J. S.; Ward, J. W.; Clayden, J. 'Reverse biomimetic' synthesis of l-arogenate and its stabilized analogues from l-tyrosine. Chemical science 2021, 12, 11394–11398. doi:10.1039/d1sc03554a
• Liu, G.-Q.; Opatz, T. Recent Advances in the Synthesis of Piperidines: Functionalization of Preexisting Ring Systems. Advances in Heterocyclic Chemistry; Elsevier, 2018; Vol. 125, pp 107–234. doi:10.1016/bs.aihch.2017.10.001
• Liu, K.; Liu, L.-L.; Gu, C.-Z.; Dai, B.; He, L. Aryne-induced dearomatized phosphonylation of electron-deficient azaarenes. RSC Advances 2016, 6, 33606–33610. doi:10.1039/c6ra02128j
• Cossar, P. J.; Hizartzidis, L.; Simone, M. I.; McCluskey, A.; Gordon, C. P. The expanding utility of continuous flow hydrogenation. Organic & biomolecular chemistry 2015, 13, 7119–7130. doi:10.1039/c5ob01067e
• Ding, Q.; Zhou, X.; Fan, R. Recent advances in dearomatization of heteroaromatic compounds. Organic & biomolecular chemistry 2014, 12, 4807–4815. doi:10.1039/c4ob00371c
• Clayden, J. Lithium Compounds in Organic Synthesis - Dearomatization and Aryl Migration in Organolithium Chemistry. Lithium Compounds in Organic Synthesis 2014, 375–396. doi:10.1002/9783527667512.ch13
• Harvey, R. A.; Karlubíková, O.; Parris, S.; Clayden, J. Dearomatising cyclisation of lithiated allyl phenyl ethers: the role of an oxazoline substituent. Tetrahedron Letters 2013, 54, 4064–4066. doi:10.1016/j.tetlet.2013.05.098
• Senczyszyn, J.; Brice, H.; Clayden, J. Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides. Organic letters 2013, 15, 1922–1925. doi:10.1021/ol400571j
• Parameswarappa, S. G.; Pigge, F. C. Intramolecular cyclization manifolds of 4-alkylpyridines bearing ambiphilic side chains: construction of spirodihydropyridines or benzylic cyclization via anhydrobase intermediates. The Journal of organic chemistry 2012, 77, 8038–8048. doi:10.1021/jo301247c
• Crotti, S.; Berti, F.; Pineschi, M. Copper-Catalyzed Perkin–Acyl-Mannich Reaction of Acetic Anhydride with Pyridine: Expeditious Entry to Unconventional Piperidines. Organic letters 2011, 13, 5152–5155. doi:10.1021/ol202027k

Explore citations to this article at