A short and efficient synthesis of valsartan via a Negishi reaction

Scholarly Works

• Bhattacharya, A.; Manivannan, V. Colorimetric detection of Pd2+ and Ni2+ ions using a probe having benzo[d]imidazo[2,1-b]thiazole and pyrene rings: Application in detection of Pd2+ ion in anti-hypertensive drugs. Microchemical Journal 2024, 200, 110440. doi:10.1016/j.microc.2024.110440
• Ali, H. A.; Ismail, M. A.; Fouda, A. E.-A. S.; Ghaith, E. A. A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects. RSC advances 2023, 13, 18262–18305. doi:10.1039/d3ra03531j
• Wang, Y.-F.; Ren, X.-Y.; Zhang, W.; Rao, G.-W. Research Progress in Pharmacological Mechanisms, Structure-Activity Relationship and Synthesis of Sartans. Current medicinal chemistry 2023, 30, 2247–2266. doi:10.2174/0929867329666220829101436
• Boyle, M.; Livingstone, K.; Henry, M. C.; Elwood, J. M. L.; Lopez-Fernandez, J. D.; Jamieson, C. Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides. Organic letters 2021, 24, 334–338. doi:10.1021/acs.orglett.1c03993
• Kar, S.; Sanderson, H.; Roy, K.; Benfenati, E.; Leszczynski, J. Green Chemistry in the Synthesis of Pharmaceuticals. Chemical reviews 2021, 122, 3637–3710. doi:10.1021/acs.chemrev.1c00631
• Ray, A.; Atal, S.; Sadasivam, B. Understanding the molecular-pharmaceutical basis of sartan recalls focusing on valsartan. Global cardiology science & practice 2020, 2020, e202025. doi:10.21542/gcsp.2020.25
• Maier, M. C.; Valotta, A.; Hiebler, K.; Soritz, S.; Gavric, K.; Grabner, B.; Gruber-Woelfler, H. 3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow. Organic Process Research & Development 2020, 24, 2197–2207. doi:10.1021/acs.oprd.0c00228
• Parr, M. K.; Joseph, J. F. NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines. Journal of pharmaceutical and biomedical analysis 2018, 164, 536–549. doi:10.1016/j.jpba.2018.11.010
• Maralla, Y.; Sonawane, S. H.; Kashinath, D.; Pimplapure, M. S.; Paplal, B. Process Intensification of Tetrazole reaction through tritylation of 5-[4′-(Methyl) Biphenyl-2-Yl] using microreactors. Chemical Engineering and Processing: Process Intensification 2017, 112, 9–17. doi:10.1016/j.cep.2016.12.003
• Moselage, M.; Li, J.; Ackermann, L. Cobalt-Catalyzed C―H Activation. ACS Catalysis 2015, 6, 230–263.
• Moselage, M.; Li, J.; Ackermann, L. Cobalt-Catalyzed C–H Activation. ACS Catalysis 2015, 6, 498–525. doi:10.1021/acscatal.5b02344
• Li, J.; Ackermann, L. Cobalt‐Catalyzed C ? H Arylations with Weakly‐Coordinating Amides and Tetrazoles: Expedient Route to Angiotensin‐II‐Receptor Blockers. Chemistry (Weinheim an der Bergstrasse, Germany) 2015, 21, 5718–5722. doi:10.1002/chem.201500552
• Gupta, P.; Mahajan, A. Green chemistry approaches as sustainable alternatives to conventional strategies in the pharmaceutical industry. RSC Advances 2015, 5, 26686–26705. doi:10.1039/c5ra00358j
• Santra, S.; Hota, P. K.; Bhattacharyya, R.; Bera, P.; Ghosh, P.; Mandal, S. K. Palladium Nanoparticles on Graphite Oxide: A Recyclable Catalyst for the Synthesis of Biaryl Cores. ACS Catalysis 2013, 3, 2776–2789. doi:10.1021/cs400468h
• Reddy, G. A.; Reddy, K. H.; Kumar, M. N.; Sharma, H. Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography. ISRN Analytical Chemistry 2013, 2013, 1–5. doi:10.1155/2013/542516
• Diers, E.; Kumar, N. Y. P.; Mejuch, T.; Marek, I.; Ackermann, L. Carboxylate-assisted ruthenium(II)-catalyzed C–H arylations of 5-aryl tetrazoles: step-economical access to Valsartan. Tetrahedron 2013, 69, 4445–4453. doi:10.1016/j.tet.2013.01.006
• Malik, M. A.; Wani, M. Y.; Al-Thabaiti, S. A.; Shiekh, R. A. Tetrazoles as carboxylic acid isosteres: chemistry and biology. Journal of Inclusion Phenomena and Macrocyclic Chemistry 2013, 78, 15–37. doi:10.1007/s10847-013-0334-x
• Colacino, E.; Martinez, J.; Lamaty, F. doi:10.1002/9781118342886.ch2

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