Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

Scholarly Works

• Al-Dies, A.-A. M.; El-Wahab, A. H. F. A.; Alamri, A. A.; Borik, R. M.; Mohamed, H. M.; Assirey, E. A.; Alsehli, M. H.; Moussa, Z.; Alzamly, A.; Mehany, A. B.; Elhenawy, A. A.; El-Agrody, A. M. Synthesis, crystal structure, DFT studies, molecular docking, of 2-amino-6-methoxy-4-(4-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile as tyrosinase inhibitor. Journal of Molecular Structure 2024, 140289. doi:10.1016/j.molstruc.2024.140289
• El-Wahab, A. H. F. A.; Borik, R. M.; Al-Dies, A.-A. M.; Fouda, A. M.; Mohamed, H. M.; El-Eisawy, R. A.; Sharaf, M. H.; Alzahrani, A. Y. A.; Elhenawy, A. A.; El-Agrody, A. M. Targeted potent antimicrobial and antitumor oxygen-heterocyclic-based pyran analogues: synthesis and computational studies. Scientific reports 2024, 14, 9862. doi:10.1038/s41598-024-59193-2
• Abd El-Wahab, A. H. F.; Borik, R. M. A.; Al-Dies, A.-A. M.; Fouda, A. M.; Mohamed, H. M.; El-Eisawy, R. A.; Mora, A.; El-Nassag, M. A. A.; Abd Elhady, A. M.; Elhenawy, A. A.; El-Agrody, A. M. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Scientific reports 2024, 14, 7589. doi:10.1038/s41598-024-56197-w
• Fouda, A. M.; El-Eisawy, R.; El-Nassag, M. A.; Mohamed, H. M.; Fekry, A. H.; El-Mawgoud, H. K.; Shati, A. A.; Alfaifi, M. Y.; Elbehairi, S. E. I.; Elhenawy, A. A.; Mora, A.; El-Agrody, A. M. Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and molecular docking studies. Journal of Molecular Structure 2024, 1295, 136518. doi:10.1016/j.molstruc.2023.136518
• Ahmed Borik, R. M.; Amri, N. J. H.; Mukhrish, Y. E.; Abd El-Wahab, A. H. F.; Mohamed, H. M.; Ibrahim, D. A. E.-S.; Deeb, A. D. H. Design, Synthesis, Reactions, Molecular Docking, Antitumor Activities of Novel Naphthopyran, Naphthopyranopyrimidines, and Naphthoyranotriazolopyrimidine Derivatives. Current Organic Chemistry 2023, 27, 1717–1727. doi:10.2174/0113852728264994231018063921
• Abd El-Wahab, A. H. F.; Mohamed, H. M. Synthesis and DFT Study of 7-Bromophenylnaphthopyran Moieties. Asian Journal of Chemistry 2023, 35, 1819–1826. doi:10.14233/ajchem.2023.28032
• Al-Harbi, L. M.; Al-Harbi, E. A.; Okasha, R. M.; El-Eisawy, R. A.; El-Nassag, M. A. A.; Mohamed, H. M.; Fouda, A. M.; Elhenawy, A. A.; Mora, A.; El-Agrody, A. M.; El-Mawgoud, H. K. A. Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels. Journal of enzyme inhibition and medicinal chemistry 2023, 38, 2155814. doi:10.1080/14756366.2022.2155814
• Albalawi, F. F.; El-Nassag, M. A. A.; El-Eisawy, R. A.; Mohamed, M. B. I.; Fouda, A. M.; Afifi, T. H.; Elhenawy, A. A.; Mora, A.; El-Agrody, A. M.; El-Mawgoud, H. K. A. Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects. International journal of molecular sciences 2022, 24, 49. doi:10.3390/ijms24010049
• Okasha, R. M.; Fouda, A. M.; Bajaber, M. A.; Ghabbour, H. A.; E. Amr, A. E.-G.; Naglah, A. M.; Almehizia, A. A.; Elhenawy, A. A.; El-Agrody, A. M. The Crystal Structure of 3-Amino-1-(4-Chlorophenyl)-9-Methoxy-1H-Benzo[f]Chromene-2-Carbonitrile: Antimicrobial Activity and Docking Studies. Crystals 2022, 12, 982. doi:10.3390/cryst12070982
• El-Agrody, A. M.; Fouda, A. M.; Mohamed, H. M.; Alshahrani, M. Y.; Ghabbour, H. A.; Amr, A. E.-G. E.; Okasha, R. M.; Naglah, A. M.; Almehizia, A. A.; Elhenawy, A. A. The Crystal Structure of 2-Amino-4-(2,3-Dichlorophenyl)-6-Methoxy-4H-Benzo[h]chromene-3-Carbonitrile: Antitumor and Tyrosine Kinase Receptor Inhibition Mechanism Studies. Crystals 2022, 12, 737. doi:10.3390/cryst12050737
• El-Mawgoud, H. K. A.; Fouda, A. M.; El-Nassag, M. A. A.; Elhenawy, A. A.; Alshahrani, M. Y.; El-Agrody, A. M. Discovery of novel rigid analogs of 2-naphthol with potent anticancer activity through multi-target topoisomerase I & II and tyrosine kinase receptor EGFR & VEGFR-2 inhibition mechanism. Chemico-biological interactions 2022, 355, 109838. doi:10.1016/j.cbi.2022.109838
• Fouda, A. M.; El-Nassag, M. A. A.; Elhenawy, A. A.; Shati, A. A.; Alfaifi, M. Y.; Elbehairi, S. E. I.; Alam, M. M.; El-Agrody, A. M. Synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives and exploring molecular and cytotoxic properties based on DFT and molecular docking studies. Journal of Molecular Structure 2022, 1249, 131555. doi:10.1016/j.molstruc.2021.131555
• Parrino, B.; Cascioferro, S.; Carbone, D.; Cirrincione, G.; Diana, P. Eight-Membered Rings With Two Heteroatoms 1,3. Comprehensive Heterocyclic Chemistry IV; Elsevier, 2022; pp 150–257. doi:10.1016/b978-0-12-818655-8.00125-6
• Parrino, B.; Cascioferro, S.; Carbone, D.; Pecoraro, C.; Cirrincione, G.; Diana, P. Advances in Heterocyclic Chemistry - Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry. Advances in Heterocyclic Chemistry; Elsevier, 2022; pp 1–57. doi:10.1016/bs.aihch.2020.11.001
• Tataringa, G.; Zbancioc, A. M. Coumarin Derivatives with Antimicrobial and Antioxidant Activities. Phytochemicals in Human Health; IntechOpen, 2020. doi:10.5772/intechopen.88096
• Rahmawati, I.; Amini, H. W.; Palupi, B.; Rizkiana, M. F. Molecular modeling of anti-microbacterial agent by QSAR study of diiodocoumarin derivatives. In AIP Conference Proceedings, AIP Publishing, 2020; pp 20020 ff. doi:10.1063/5.0014543
• Xu, C.; Wang, K.; Li, D.; Lin, L.; Feng, X. Asymmetric Synthesis of Oxa‐Bridged Oxazocines by Rh(II)/Zn(II) Relay Catalytic [4+3] Cycloaddition Reaction. Angewandte Chemie 2019, 131, 18609–18613. doi:10.1002/ange.201910898
• Xu, C.; Wang, K.; Li, D.; Lin, L.; Feng, X. Asymmetric Synthesis of Oxa-Bridged Oxazocines through a Catalytic RhII/ZnII Relay [4+3] Cycloaddition Reaction. Angewandte Chemie (International ed. in English) 2019, 58, 18438–18442. doi:10.1002/anie.201910898
• Wang, Y.-A.; Liu, T.; Zhong, G.-Q. Synthesis, characterization and applications of copper(II) complexes with Schiff bases derived from chitooligosaccharide and iodosubstituted salicylaldehyde. Carbohydrate polymers 2019, 224, 115151. doi:10.1016/j.carbpol.2019.115151
• Lam, H.; Qureshi, Z.; Wegmann, M.; Lautens, M. Transition-Metal-Free [4+3]-Cycloaddition of ortho-Quinone Methides and Isomünchnones: Catalytic and Diastereoselective Assembly of Oxa-bridged Oxazocine Scaffolds. Angewandte Chemie (International ed. in English) 2018, 57, 16185–16189. doi:10.1002/anie.201810760

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