C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

Scholarly Works

• Abd El-Mawgoud, H. K.; AboulMagd, A. M.; Nemr, M. T. M.; Hemdan, M. M.; Hassaballah, A. I.; Farag, P. S. Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers. Bioorganic chemistry 2024, 150, 107622. doi:10.1016/j.bioorg.2024.107622
• Elmongy, E.; Henidi, H. In Silico Evaluation of a Promising Key Intermediate Thieno [2,3-d] Pyrimidine Derivative with Expected JAK2 Kinase Inhibitory Activity. Molbank 2022, 2022, M1352. doi:10.3390/m1352
• Elmongy, E. I.; Altwaijry, N.; Attallah, N. G. M.; AlKahtani, M. M.; Henidi, H. A. In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation. Pharmaceuticals (Basel, Switzerland) 2022, 15, 170. doi:10.3390/ph15020170
• Elmongy, E. I.; Attallah, N. G. M.; Altwaijry, N.; AlKahtani, M. M.; Henidi, H. A. Design and Synthesis of New Thiophene/Thieno[2,3-d]pyrimidines along with Their Cytotoxic Biological Evaluation as Tyrosine Kinase Inhibitors in Addition to Their Apoptotic and Autophagic Induction. Molecules (Basel, Switzerland) 2021, 27, 123. doi:10.3390/molecules27010123
• Shaker, M.; Elhamifar, D. Pd-containing IL-based ordered nanostructured organosilica: A powerful and recoverable catalyst for Sonogashira reaction. Tetrahedron Letters 2020, 61, 152481. doi:10.1016/j.tetlet.2020.152481
• Sharaky, M. M.; Kamel, M.; Aziz, M. A.; Omran, M. M.; Rageh, M. M.; Abouzid, K. A.; Shouman, S. A. Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines. Journal of enzyme inhibition and medicinal chemistry 2020, 35, 1641–1656. doi:10.1080/14756366.2020.1804383
• Bozorov, K.; Zhao, J.; Elmuradov, B. Z.; Pataer, A.; Aisa, H. A. Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties. European journal of medicinal chemistry 2015, 102, 552–573. doi:10.1016/j.ejmech.2015.08.018
• Devari, S.; Kumar, M.; Deshidi, R.; Rizvi, M. A.; Shah, B. A. A general metal-free approach for the stereoselective synthesis of C-glycals from unactivated alkynes. Beilstein journal of organic chemistry 2014, 10, 2649–2653. doi:10.3762/bjoc.10.277
• Gorja, D. R.; Kumar, K. S.; Dulla, B.; Mukkanti, K.; Pal, M. Pd/C‐Mediated Alkynylation of Indazoles: Synthesis and Pharmacological Evaluation of Mono and Dialkynyl‐Substituted Indazoles. Journal of Heterocyclic Chemistry 2013, 51, 374–382. doi:10.1002/jhet.1602
• Rossy, C.; Majimel, J.; Fouquet, E.; Delacôte, C.; Boujtita, M.; Labrugère, C.; Tréguer-Delapierre, M.; Felpin, F.-X. Stabilisation of Carbon-Supported Palladium Nanoparticles through the Formation of an Alloy with Gold: Application to the Sonogashira Reaction. Chemistry (Weinheim an der Bergstrasse, Germany) 2013, 19, 14024–14029. doi:10.1002/chem.201300347
• Li, H.; Chen, C.; Xu, S.; Cao, X. Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors. Journal of Chemistry 2013, 2013, 1–6. doi:10.1155/2013/692074
• Elmuradov, B. Thieno(2,3-d)Pyrimidin-4-Ones. Part 2 * . Condensation of 2,3-Disubstituted Thieno(2,3- d)Pyrimidin-4-Ones with Aldehydes. American Chemical Science Journal 2013, 3, 164–177. doi:10.9734/acsj/2013/2966
• Adepu, R.; Kumar, K. S.; Sandra, S.; Rambabu, D.; Krishna, G. R.; Reddy, C. M.; Kandale, A.; Misra, P.; Pal, M. C-N bond formation under Cu-catalysis: synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase. Bioorganic & medicinal chemistry 2012, 20, 5127–5138. doi:10.1016/j.bmc.2012.07.011
• Adepu, R.; Rambabu, D.; Prasad, B.; Meda, C. L. T.; Kandale, A.; Krishna, G. R.; Reddy, C. M.; Chennuru, L. N.; Parsa, K. V. L.; Pal, M. Novel thieno[2,3-d]pyrimidines: their design, synthesis, crystal structure analysis and pharmacological evaluation. Organic & biomolecular chemistry 2012, 10, 5554–5569. doi:10.1039/c2ob25420d
• Yet, L. Six-Membered Ring Systems: Diazines and Benzo Derivatives. Progress in Heterocyclic Chemistry 2012, 24, 393–420. doi:10.1016/b978-0-08-096807-0.00013-0
• Nakhi, A.; Prasad, B.; Reddy, U.; Rao, R. M.; Sandra, S.; Kapavarapu, R.; Rambabu, D.; Krishna, G. R.; Reddy, C. M.; Ravada, K.; Misra, P.; Iqbal, J.; Pal, M. A new route to indoles via in situ desilylation–Sonogashira strategy: identification of novel small molecules as potential anti-tuberculosis agents. MedChemComm 2011, 2, 1006–1010. doi:10.1039/c1md00148e

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