Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

Scholarly Works

• Bernhard, L. M.; Gröger, H. Overcoming a Conceptual Limitation of Industrial ε-Caprolactone Production via Chemoenzymatic Synthesis in Organic Medium. ChemSusChem 2024, e202400073. doi:10.1002/cssc.202400073
• Koch, W. doi:10.1002/9783527843954.ch8
• Xu, X.; Hilberath, T.; Hollmann, F. Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases – A bright future for sustainable chemical synthesis. Current Opinion in Green and Sustainable Chemistry 2023, 39, 100745. doi:10.1016/j.cogsc.2022.100745
• Perz, F.; Bormann, S.; Ulber, R.; Alcalde, M.; Bubenheim, P.; Hollmann, F.; Holtmann, D.; Liese, A. Enzymatic Oxidation of Butane to 2-Butanol in a Bubble Column. ChemCatChem 2020, 12, 3666–3669. doi:10.1002/cctc.202000431
• Wiltschi, B.; Cernava, T.; Dennig, A.; Casas, M. G.; Geier, M.; Gruber, S.; Haberbauer, M.; Heidinger, P.; Acero, E. H.; Kratzer, R.; Luley-Goedl, C.; Müller, C. A.; Pitzer, J.; Ribitsch, D.; Sauer, M.; Schmölzer, K.; Schnitzhofer, W.; Sensen, C. W.; Soh, J.; Steiner, K.; Winkler, C. K.; Winkler, M.; Wriessnegger, T. Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications. Biotechnology advances 2020, 40, 107520. doi:10.1016/j.biotechadv.2020.107520
• Wedde, S.; Biermann, M.; Choi, J. E.; Oike, K.; Zumbrägel, N.; Gröger, H. Green Oxidation in Organic Synthesis; Wiley, 2019; pp 439–496. doi:10.1002/9781119304197.ch16
• Shoji, O.; Watanabe, Y. Monooxygenation of Nonnative Substrates Catalyzed by Bacterial Cytochrome P450s Facilitated by Decoy Molecules. Chemistry Letters 2017, 46, 278–288. doi:10.1246/cl.160963
• Soussan, L.; Pen, N.; Belleville, M.-P.; Marcano, J. S.; Paolucci-Jeanjean, D. Alkane biohydroxylation: Interests, constraints and future developments. Journal of biotechnology 2016, 222, 117–142. doi:10.1016/j.jbiotec.2016.02.007
• Kawakami, N.; Cong, Z.; Shoji, O.; Watanabe, Y. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules. Journal of Porphyrins and Phthalocyanines 2015, 19, 329–334. doi:10.1142/s1088424615500145
• Shoji, O.; Watanabe, Y. Monooxygenation of small hydrocarbons catalyzed by bacterial cytochrome p450s. Advances in experimental medicine and biology 2015, 851, 189–208. doi:10.1007/978-3-319-16009-2_7
• Park, J. H.; Lee, S. H.; Su, G.; Choi, D. S.; Nam, D. H.; Lee, J. H.; Lee, J.-K.; Yun, C.-H.; Jeong, K. J.; Park, C. B. Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis. Angewandte Chemie (International ed. in English) 2014, 54, 969–973. doi:10.1002/anie.201410059
• Park, J. H.; Lee, S. H.; Cha, G. S.; Choi, D. S.; Nam, D. H.; Lee, J. H.; Lee, J.; Yun, C.; Jeong, K. J.; Park, C. B. Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis. Angewandte Chemie 2014, 127, 983–987. doi:10.1002/ange.201410059
• Venkataraman, H.; Verkade-Vreeker, M. C. A.; Capoferri, L.; Geerke, D. P.; Vermeulen, N. P. E.; Commandeur, J. N. M. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Bioorganic & medicinal chemistry 2014, 22, 5613–5620. doi:10.1016/j.bmc.2014.06.022
• Müller, C. A.; Dennig, A.; Welters, T.; Winkler, T.; Ruff, A. J.; Hummel, W.; Gröger, H.; Schwaneberg, U. Whole-cell double oxidation of n-heptane. Journal of biotechnology 2014, 191, 196–204. doi:10.1016/j.jbiotec.2014.06.001
• Neufeld, K.; Berstenhorst, S. M. z.; Pietruszka, J. Evaluation of coumarin-based fluorogenic P450 BM3 substrates and prospects for competitive inhibition screenings. Analytical biochemistry 2014, 456, 70–81. doi:10.1016/j.ab.2014.03.022
• Ni, Y.; Holtmann, D.; Hollmann, F. How Green is Biocatalysis? To Calculate is To Know. ChemCatChem 2014, 6, 930–943. doi:10.1002/cctc.201300976
• Müller, C. A.; Akkapurathu, B.; Winkler, T.; Staudt, S.; Hummel, W.; Gröger, H.; Schwaneberg, U. In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration. Advanced Synthesis & Catalysis 2013, 355, 1787–1798. doi:10.1002/adsc.201300143
• Staudt, S.; Burda, E.; Giese, C.; Müller, C. A.; Marienhagen, J.; Schwaneberg, U.; Hummel, W.; Drauz, K.; Gröger, H. Direktoxidation von Cycloalkanen zu Cycloalkanonen mit Sauerstoff in Wasser. Angewandte Chemie 2013, 125, 2415–2419. doi:10.1002/ange.201204464
• Staudt, S.; Burda, E.; Giese, C.; Müller, C. A.; Marienhagen, J.; Schwaneberg, U.; Hummel, W.; Drauz, K.; Gröger, H. Direct oxidation of cycloalkanes to cycloalkanones with oxygen in water. Angewandte Chemie (International ed. in English) 2013, 52, 2359–2363. doi:10.1002/anie.201204464
• Neufeld, K.; Marienhagen, J.; Schwaneberg, U.; Pietruszka, J. Benzylic hydroxylation of aromatic compounds by P450 BM3. Green Chemistry 2013, 15, 2408–2421. doi:10.1039/c3gc40838h

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