Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

Scholarly Works

• Salluce, G.; Folgar-Cameán, Y.; Barba-Bon, A.; Nikšić-Franjić, I.; El Anwar, S.; Grüner, B.; Lostalé-Seijo, I.; Nau, W. M.; Montenegro, J. Size and Polarizability of Boron Cluster Carriers Modulate Chaotropic Membrane Transport. Angewandte Chemie (International ed. in English) 2024, 63, e202404286. doi:10.1002/anie.202404286
• Salluce, G.; Folgar‐Cameán, Y.; Barba‐Bon, A.; Nikšić‐Franjić, I.; El Anwar, S.; Grüner, B.; Lostalé‐Seijo, I.; Nau, W. M.; Montenegro, J. Size and Polarizability of Boron Cluster Carriers Modulate Chaotropic Membrane Transport. Angewandte Chemie 2024, 136. doi:10.1002/ange.202404286
• Klußmann, M.; Stillger, K.; Ruppel, M.; Sticker, C.-L.; Neundorf, I. Investigating the impact of thiol reactivity and disulfide formation on cellular uptake of cell-permeable peptides. Journal of peptide science : an official publication of the European Peptide Society 2024, 30, e3604. doi:10.1002/psc.3604
• Lee, H.-M.; Thai, T. D.; Lim, W.; Ren, J.; Na, D. Functional small peptides for enhanced protein delivery, solubility, and secretion in microbial biotechnology. Journal of biotechnology 2023, 375, 40–48. doi:10.1016/j.jbiotec.2023.08.008
• Tavakoli, S.; Firoozpour, L.; Davoodi, J. The synergistic effect of chimeras consisting of N-terminal smac and modified KLA peptides in inducing apoptosis in breast cancer cell lines. Biochemical and biophysical research communications 2023, 655, 138–144. doi:10.1016/j.bbrc.2023.03.008
• Nakase, I. doi:10.1002/9783527835997.ch3
• Oba, M.; Demizu, Y. doi:10.1002/9783527835997.ch1
• Hadjicharalambous, A.; Bournakas, N.; Newman, H.; Skynner, M. J.; Beswick, P. Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics. Antibiotics (Basel, Switzerland) 2022, 11, 1636. doi:10.3390/antibiotics11111636
• Szabó, I.; Yousef, M.; Soltész, D.; Bató, C.; Mező, G.; Bánóczi, Z. Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System. Pharmaceutics 2022, 14, 907. doi:10.3390/pharmaceutics14050907
• Wang, T.; Tian, L.; Cheng, Q.; Feng, S.; Zhang, H.; Zheng, Z.; Liu, Y.; Cheng, M.; Meng, Z.; Meng, Q. Pep5-based antitumor peptides containing multifunctional fragments with enhanced activity and synergistic effect. European journal of medicinal chemistry 2022, 237, 114320. doi:10.1016/j.ejmech.2022.114320
• Denardi, L. B.; Weiblen, C.; Ianiski, L. B.; Stibbe, P. C.; Pinto, S. C.; Santurio, J. M. Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 2022, 53, 509–512. doi:10.1007/s42770-022-00678-5
• Price, J. S.; Emslie, D. J. Cyclic and Non-Cyclic Pi Complexes of Manganese. Comprehensive Organometallic Chemistry IV; Elsevier, 2022; pp 378–546. doi:10.1016/b978-0-12-820206-7.00077-9
• Neundorf, I. Medical use of cell-penetrating peptides: how far have they come?. Peptide and Peptidomimetic Therapeutics; Elsevier, 2022; pp 235–254. doi:10.1016/b978-0-12-820141-1.00001-7
• Nakase, I.; Takatani-Nakase, T. Exosomes: Breast cancer-derived extracellular vesicles; recent key findings and technologies in disease progression, diagnostics, and cancer targeting. Drug metabolism and pharmacokinetics 2021, 42, 100435. doi:10.1016/j.dmpk.2021.100435
• Kumara, B. T.; Wijesiri, N. K.; Rathnayake, P. V. G. M.; Ranatunga, R. J. K. U. A Re-evaluation of the Free Energy Profiles for Cell-Penetrating Peptides Across DOPC Membranes. International Journal of Peptide Research and Therapeutics 2021, 27, 2931–2943. doi:10.1007/s10989-021-10301-0
• Lichtenstein, M.; Zabit, S.; Hauser, N.; Farouz, S.; Melloul, O.; Hirbawi, J.; Lorberboum-Galski, H. TAT for Enzyme/Protein Delivery to Restore or Destroy Cell Activity in Human Diseases. Life (Basel, Switzerland) 2021, 11, 924. doi:10.3390/life11090924
• Wester, A.; Hansen, A. M.; Hansen, P. R.; Franzyk, H. Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods. Amino acids 2021, 53, 1455–1466. doi:10.1007/s00726-021-03059-8
• Rusiecka, I.; Gągało, I.; Kocić, I. Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs. Tissue barriers 2021, 10, 1965418. doi:10.1080/21688370.2021.1965418
• Noguchi, K.; Obuki, M.; Sumi, H.; Klußmann, M.; Morimoto, K.; Nakai, S.; Hashimoto, T.; Fujiwara, D.; Fujii, I.; Yuba, E.; Takatani-Nakase, T.; Neundorf, I.; Nakase, I. Macropinocytosis-Inducible Extracellular Vesicles Modified with Antimicrobial Protein CAP18-Derived Cell-Penetrating Peptides for Efficient Intracellular Delivery. Molecular pharmaceutics 2021, 18, 3290–3301. doi:10.1021/acs.molpharmaceut.1c00244
• Streck, S.; Bohr, S. S.-R.; Birch, D.; Rades, T.; Hatzakis, N. S.; McDowell, A.; Nielsen, H. M. Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking. ACS applied bio materials 2021, 4, 3155–3165. doi:10.1021/acsabm.0c01563

Explore citations to this article at