Supporting Information
1H and 13C NMR spectra and HPLC chromatograms for compounds 3, 4, 5, 6, 8, and 16. Chromatograms from chiral HPLC analysis of rac-3 and (R)-3 and experimental details for the pharmacological characterisation for (R)-3.
| Supporting Information File 1: Experimental procedures and full characterisation of the calcilytic ligand NPS 2143. | ||
| Format: PDF | Size: 1.6 MB | Download |
Cite the Following Article
Synthesis of the calcilytic ligand NPS 2143
Henrik Johansson, Thomas Cailly, Alex Rojas Bie Thomsen, Hans Bräuner-Osborne and Daniel Sejer Pedersen
Beilstein J. Org. Chem. 2013, 9, 1383–1387.
https://doi.org/10.3762/bjoc.9.154
How to Cite
Johansson, H.; Cailly, T.; Rojas Bie Thomsen, A.; Bräuner-Osborne, H.; Sejer Pedersen, D. Beilstein J. Org. Chem. 2013, 9, 1383–1387. doi:10.3762/bjoc.9.154
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- Greenberg, H. Z.; Jahan, K. S.; Shi, J.; Ho, W.-S. V.; Albert, A. P. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca 2+ channels. European journal of pharmacology 2016, 791, 659–668. doi:10.1016/j.ejphar.2016.10.008
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Patents
- STEYAERT JAN; PARDON ELS; WOHLKÖNIG ALEXANDRE; ZÖGG THOMAS; MOS IRIS; BRÄUNER-OSBORNE HANS; MOSOLFF MATHIESEN JESPER. POSITIVE ALLOSTERIC MODULATORS OF THE CALCIUM-SENSING RECEPTOR. WO 2021105438 A1, June 3, 2021.
