Ethyl diazoacetate synthesis in flow

Scholarly Works

• Baldan, M.; Blauth, S.; Bošković, D.; Leithäuser, C.; Mendl, A.; Radulescu, L.; Schwarzer, M.; Wegner, H.; Bortz, M. Continuous Synthesis of Diazo Acetonitrile: From Experiments to Physical and Grey‐Box Modeling. Chemie Ingenieur Technik 2024, 96, 658–670. doi:10.1002/cite.202300191
• Bošković, D.; Loebbecke, S.; Panić, S.; Piscopo, C. G.; Radulescu, L. J.; Schwarzer, M. Diazoacetonitrile: Safe and Green Synthesis through Continuous Processing. Chemie Ingenieur Technik 2024, 96, 652–657. doi:10.1002/cite.202300187
• Paquin, P.; DeGrâce, N.; Bélanger-Chabot, G.; Paquin, J.-F. Synthesis of Substituted Pentafluorosulfanylpyrazoles Under Flow Conditions. The Journal of organic chemistry 2024, 89, 3552–3562. doi:10.1021/acs.joc.3c02295
• Nguyen, T.-T. H.; Navarro, A.; Ruble, J. C.; Davies, H. M. L. Stereoselective Synthesis of Either Exo- or Endo-3-Azabicyclo[3.1.0]hexane-6-carboxylates by Dirhodium(II)-Catalyzed Cyclopropanation with Ethyl Diazoacetate under Low Catalyst Loadings. Organic letters 2024, 26, 2832–2836. doi:10.1021/acs.orglett.3c03652
• Vinciarelli, G.; Barreca, G.; Coppola, M.; Ronzoni, S.; Taddei, M. Synthesis of Pyrazoles by 1,3‐Dipolar Cycloaddition under Aqueous Micellar Catalysis. European Journal of Organic Chemistry 2022, 2022. doi:10.1002/ejoc.202200632
• van Summeren, L. T. C. G.; Gerretzen, J.; Rutjes, F. P. J. T.; Bloemberg, T. G. Optimization of continuous-flow diphenyldiazomethane synthesis: an integrated undergraduate chemistry experiment. Journal of Flow Chemistry 2020, 11, 59–66. doi:10.1007/s41981-020-00107-4
• Dallinger, D.; Gutmann, B.; Kappe, C. O. The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow. Accounts of chemical research 2020, 53, 1330–1341. doi:10.1021/acs.accounts.0c00199
• Tan, Z.; Li, Z.; Jin, G.; Yu, C. Continuous-Flow Process for the Synthesis of 5-Nitro-1,4-dihydro-1,4-methanonaphthalene. Organic Process Research & Development 2018, 23, 31–37. doi:10.1021/acs.oprd.8b00281
• Dimitriou, E.; Jones, R. H.; Pritchard, R. G.; Miller, G. J.; O'Brien, M. Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold. Tetrahedron 2018, 74, 6795–6803. doi:10.1016/j.tet.2018.09.025
• Empel, C.; Hock, K. J.; Koenigs, R. M. Iron-catalysed Carbene-Transfer Reactions of Diazo Acetonitrile. Organic & biomolecular chemistry 2018, 16, 7129–7133. doi:10.1039/c8ob01991f
• Hock, K. J.; Koenigs, R. M. The Generation of Diazo Compounds in Continuous-Flow. Chemistry (Weinheim an der Bergstrasse, Germany) 2018, 24, 10571–10583. doi:10.1002/chem.201800136
• Tomilov, Y. V.; Menchikov, L. G.; Novikov, R. A.; Ivanova, O. A.; Trushkov, I. V. Methods for the synthesis of donor-acceptor cyclopropanes. Russian Chemical Reviews 2018, 87, 201–250. doi:10.1070/rcr4787
• O'Brien, M.; Cooper, D. A.; Mhembere, P. The continuous-flow synthesis of carbazate hydrazones using a simplified computer-vision controlled liquid–liquid extraction system. Tetrahedron Letters 2016, 57, 5188–5191. doi:10.1016/j.tetlet.2016.10.018
• Movsisyan, M.; Delbeke, E.; Berton, J.; Battilocchio, C.; Ley, S. V.; Stevens, C. V. Taming hazardous chemistry by continuous flow technology. Chemical Society reviews 2016, 45, 4892–4928. doi:10.1039/c5cs00902b
• Hu, T.; Baxendale, I. R.; Baumann, M. Exploring Flow Procedures for Diazonium Formation. Molecules (Basel, Switzerland) 2016, 21, 918. doi:10.3390/molecules21070918
• Müller, S. T. R.; Hokamp, T.; Ehrmann, S.; Hellier, P.; Wirth, T. Ethyl Lithiodiazoacetate: Extremely Unstable Intermediate Handled Efficiently in Flow. Chemistry (Weinheim an der Bergstrasse, Germany) 2016, 22, 11940–11942. doi:10.1002/chem.201602133
• Mertens, L.; Hock, K. J.; Koenigs, R. M. Fluoroalkyl‐Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines. Chemistry (Weinheim an der Bergstrasse, Germany) 2016, 22, 9542–9545. doi:10.1002/chem.201601707
• Pieber, B.; Kappe, C. O. Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies. Organic letters 2016, 18, 1076–1079. doi:10.1021/acs.orglett.6b00194
• Mueller, S. T. R.; Murat, A.; Hellier, P.; Wirth, T. Toward a Large-Scale Approach to Milnacipran Analogues Using Diazo Compounds in Flow Chemistry. Organic Process Research & Development 2015, 20, 495–502. doi:10.1021/acs.oprd.5b00308
• Mykhailiuk, P. K. New Life for Diazoacetonitrile (N2CHCN): in situ Generation and Practical Synthesis of CN-Pyrazoles†. European Journal of Organic Chemistry 2015, 2015, 7235–7239. doi:10.1002/ejoc.201501027

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