Development of peptidomimetic ligands of Pro-Leu-Gly-NH₂ as allosteric modulators of the dopamine D₂ receptor

Scholarly Works

• Girmaw, F. Review on allosteric modulators of dopamine receptors so far. Health science reports 2024, 7, e1984. doi:10.1002/hsr2.1984
• Silva-Reis, S. C.; Correia, X. C.; Costa-Almeida, H. F.; Pires-Lima, B. L.; Maronde, D.; Costa, V. M.; García-Mera, X.; Cruz, L.; Brea, J.; Loza, M. I.; Rodríguez-Borges, J. E.; Sampaio-Dias, I. E. Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors. ACS medicinal chemistry letters 2023, 14, 1656–1663. doi:10.1021/acsmedchemlett.3c00264
• Kaczor, A. A.; Wróbel, T. M.; Bartuzi, D. Allosteric Modulators of Dopamine D2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis. Molecules (Basel, Switzerland) 2022, 28, 178. doi:10.3390/molecules28010178
• Aathi, M. S.; Kumar, C.; Prabhudesai, K. S.; Shanmugarajan, D.; Idicula-Thomas, S. Mapping of FSHR agonists and antagonists binding sites to identify potential peptidomimetic modulators. Biochimica et biophysica acta. Biomembranes 2021, 1864, 183842. doi:10.1016/j.bbamem.2021.183842
• Dias, I.; Silva-Reis, S. C.; Pires-Lima, B. L.; Correia, X. C.; Costa-Almeida, H. F. A Convenient On-Site Oxidation Strategy for the N-hydroxylation of Melanostatin Neuropeptide using Cope Elimination. Synthesis 2021, 54, 2031–2036. doi:10.1055/a-1695-1095
• Olson, K. M.; Traynor, J. R.; Alt, A. Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators. Frontiers in chemistry 2021, 9, 671483. doi:10.3389/fchem.2021.671483
• Sampaio-Dias, I. E.; Rodríguez-Borges, J. E.; Yáñez-Pérez, V.; Arrasate, S.; Llorente, J.; Brea, J.; Bediaga, H.; Viña, D.; Loza, M. I.; Caamaño, O.; García-Mera, X.; González-Díaz, H. Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML). ACS chemical neuroscience 2020, 12, 203–215. doi:10.1021/acschemneuro.0c00687
• Mulamreddy, R.; Lubell, W. D. Constrained Glu‐Gly and Gln‐Gly dipeptide surrogates from γ‐substituted α‐amino‐δ‐lactam synthesis. Peptide Science 2020, 112. doi:10.1002/pep2.24149
• López-Rodríguez, M. L.; Benhamú, B.; Vázquez-Villa, H. Allosteric modulators targeting GPCRs. GPCRs; Elsevier, 2020; pp 195–241. doi:10.1016/b978-0-12-816228-6.00011-8
• Geranurimi, A.; Lubell, W. D. Diversity-Oriented Syntheses of β-Substituted α-Amino γ-Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues. Organic letters 2018, 20, 6126–6129. doi:10.1021/acs.orglett.8b02575
• Wold, E. A.; Chen, J.; Cunningham, K. A.; Zhou, J. Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts. Journal of medicinal chemistry 2018, 62, 88–127. doi:10.1021/acs.jmedchem.8b00875
• Oliver, M.; Gadais, C.; García-Pindado, J.; Teixidó, M.; Lensen, N.; Chaume, G.; Brigaud, T. Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the L-prolyl-L-leucyl glycinamide (PLG) tripeptide. RSC advances 2018, 8, 14597–14602. doi:10.1039/c8ra02511h
• St-Cyr, D. J.; García-Ramos, Y.; Doan, N.-D.; Lubell, W. D. Aminolactam, N-Aminoimidazolone, and N-Aminoimdazolidinone Peptide Mimics. Topics in Heterocyclic Chemistry; Springer International Publishing, 2017; pp 125–175. doi:10.1007/7081_2017_204
• Sampaio-Dias, I. E.; Sousa, C.; García-Mera, X.; da Costa, J. F.; Caamaño, O.; Rodríguez-Borges, J. E. Novel L-prolyl-L-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R. Organic & biomolecular chemistry 2016, 14, 11065–11069. doi:10.1039/c6ob02248k
• Chingle, R.; Lubell, W. D. Azopeptides: Synthesis and Pericyclic Chemistry. Organic letters 2015, 17, 5400–5403. doi:10.1021/acs.orglett.5b02723
• Aillard, B.; Kilburn, J. D.; Blaydes, J. P.; Tizzard, G. J.; Findlow, S. C.; Werner, J. M.; Bloodworth, S. Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-L-proline type II helix conformation. Organic & biomolecular chemistry 2015, 13, 4562–4569. doi:10.1039/c5ob00180c
• Basu, D.; Tian, Y.; Hui, P.; Bhandari, J.; Johnson, R. L.; Mishra, R. K. Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA. Peptides 2015, 66, 58–62. doi:10.1016/j.peptides.2015.01.004
• Belen’kii, L. I.; Evdokimenkova, Y. B. The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013. Advances in Heterocyclic Chemistry 2015, 116, 193–363. doi:10.1016/bs.aihch.2015.04.002
• Scognamiglio, P. L.; Morelli, G.; Marasco, D. Synthetic and Structural Routes for the Rational Conversion of Peptides into Small Molecules. Methods in molecular biology (Clifton, N.J.) 2014, 1268, 159–193. doi:10.1007/978-1-4939-2285-7_8
• Nair, R. V.; Baravkar, S. B.; Ingole, T. S.; Sanjayan, G. J. Synthetic turn mimetics and hairpin nucleators: Quo Vadimus?. Chemical communications (Cambridge, England) 2014, 50, 13874–13884. doi:10.1039/c4cc03114h

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